Homocysteine and thyroid diseases
Homocysteine (Hcy) is an important intermediate product in methionine metabolism which plays a key role in the methylation of DNA, RNA and proteins. High level of Hcy can induce endothelial cell damage, promote the release of inflammatory factors, stimulate oxidative stress and inhibit the fibrinoly...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1572997/full |
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| author | Lili Cui Fei Wang Chunyu Li Fan Liu Haipeng Wang Junyu Zhao |
| author_facet | Lili Cui Fei Wang Chunyu Li Fan Liu Haipeng Wang Junyu Zhao |
| author_sort | Lili Cui |
| collection | DOAJ |
| description | Homocysteine (Hcy) is an important intermediate product in methionine metabolism which plays a key role in the methylation of DNA, RNA and proteins. High level of Hcy can induce endothelial cell damage, promote the release of inflammatory factors, stimulate oxidative stress and inhibit the fibrinolytic system. Numerous studies have confirmed the close relationship between hyperhomocysteinemia (HHcy) and the occurrence/development of various diseases such as cardiovascular diseases, neurological disorders, thrombotic diseases, and tumors. With the rising incidence of thyroid diseases, the relationship between Hcy and thyroid diseases has attracted widespread attention. It has been found that HHcy may be directly or indirectly associated with the development of hypothyroidism, but the findings with hyperthyroidism, chronic lymphocytic thyroiditis and reduced thyroid hormone sensitivity are controversial. This article reviews the research progress of Hcy and thyroid diseases, with a view to providing new ideas for the prevention and clinical treatment of diseases. |
| format | Article |
| id | doaj-art-36dd3f8b603b45a682f45162f165fa35 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-36dd3f8b603b45a682f45162f165fa352025-08-20T03:33:37ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-07-011610.3389/fendo.2025.15729971572997Homocysteine and thyroid diseasesLili Cui0Fei Wang1Chunyu Li2Fan Liu3Haipeng Wang4Junyu Zhao5Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong First Medical University, Shandong Key Laboratory of Rheumatic Diseaseand Translational Medicine, Shandong Institute of Nephrology, Jinan, ChinaDepartment of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong First Medical University, Shandong Key Laboratory of Rheumatic Diseaseand Translational Medicine, Shandong Institute of Nephrology, Jinan, ChinaDepartment of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong First Medical University, Shandong Key Laboratory of Rheumatic Diseaseand Translational Medicine, Shandong Institute of Nephrology, Jinan, ChinaDepartment of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong First Medical University, Shandong Key Laboratory of Rheumatic Diseaseand Translational Medicine, Shandong Institute of Nephrology, Jinan, ChinaCollege of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong First Medical University, Shandong Key Laboratory of Rheumatic Diseaseand Translational Medicine, Shandong Institute of Nephrology, Jinan, ChinaHomocysteine (Hcy) is an important intermediate product in methionine metabolism which plays a key role in the methylation of DNA, RNA and proteins. High level of Hcy can induce endothelial cell damage, promote the release of inflammatory factors, stimulate oxidative stress and inhibit the fibrinolytic system. Numerous studies have confirmed the close relationship between hyperhomocysteinemia (HHcy) and the occurrence/development of various diseases such as cardiovascular diseases, neurological disorders, thrombotic diseases, and tumors. With the rising incidence of thyroid diseases, the relationship between Hcy and thyroid diseases has attracted widespread attention. It has been found that HHcy may be directly or indirectly associated with the development of hypothyroidism, but the findings with hyperthyroidism, chronic lymphocytic thyroiditis and reduced thyroid hormone sensitivity are controversial. This article reviews the research progress of Hcy and thyroid diseases, with a view to providing new ideas for the prevention and clinical treatment of diseases.https://www.frontiersin.org/articles/10.3389/fendo.2025.1572997/fullhomocysteinehyperhomocysteinemiahypothyroidismhyperthyroidismMTHFR |
| spellingShingle | Lili Cui Fei Wang Chunyu Li Fan Liu Haipeng Wang Junyu Zhao Homocysteine and thyroid diseases Frontiers in Endocrinology homocysteine hyperhomocysteinemia hypothyroidism hyperthyroidism MTHFR |
| title | Homocysteine and thyroid diseases |
| title_full | Homocysteine and thyroid diseases |
| title_fullStr | Homocysteine and thyroid diseases |
| title_full_unstemmed | Homocysteine and thyroid diseases |
| title_short | Homocysteine and thyroid diseases |
| title_sort | homocysteine and thyroid diseases |
| topic | homocysteine hyperhomocysteinemia hypothyroidism hyperthyroidism MTHFR |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1572997/full |
| work_keys_str_mv | AT lilicui homocysteineandthyroiddiseases AT feiwang homocysteineandthyroiddiseases AT chunyuli homocysteineandthyroiddiseases AT fanliu homocysteineandthyroiddiseases AT haipengwang homocysteineandthyroiddiseases AT junyuzhao homocysteineandthyroiddiseases |