Purpureocillium lilacinum as unusual cause of pulmonary infection in immunocompromised hosts
Purpureocillium lilacinum (P. lilacinum) is an emergent pathogenic mold that presents more commonly as an ocular infection, cutaneous and/or subcutaneous infections in patients that are usually immunocompromised. A pulmonary presentation is rare, the clinical presentation is fever and cough with ra...
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The Journal of Infection in Developing Countries
2020-04-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/12235 |
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| author | Manuel A Salazar-González Jorge R Violante-Cumpa Christian G Alfaro-Rivera Hiram Villanueva-Lozano Rogelio de Jesús Treviño-Rangel Gloria M González |
| author_facet | Manuel A Salazar-González Jorge R Violante-Cumpa Christian G Alfaro-Rivera Hiram Villanueva-Lozano Rogelio de Jesús Treviño-Rangel Gloria M González |
| author_sort | Manuel A Salazar-González |
| collection | DOAJ |
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Purpureocillium lilacinum (P. lilacinum) is an emergent pathogenic mold that presents more commonly as an ocular infection, cutaneous and/or subcutaneous infections in patients that are usually immunocompromised. A pulmonary presentation is rare, the clinical presentation is fever and cough with radiographic presentation as pleural effusion, single-lung consolidation, and cavitary pulmonary disease. We present a case of a patient with hematologic malignancy with febrile neutropenia; after receiving chemotherapy, the patient developed a pulmonary infection with multiple bilateral consolidations shown in the thoracic computed tomography scan. Fever persisted in spite of the use of wide-spectrum antibiotics and amphotericin. Bronchoalveolar lavage was performed and the samples were cultured, isolating in the Sabouraud Dextrous Agar a filamentous fungi growth with purple colonies that were identified morphologically as P. lilacinum and later it was confirmed by molecular methods. Once the infectious agent was identified, we continued amphotericin and oral voriconazole was added to the treatment with complete resolution of the infection. The report aims to create awareness of this emerging infectious disease, as there is little information concerning the treatment and the prognosis of patients infected by P. lilacinum with a pulmonary presentation.
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| format | Article |
| id | doaj-art-36d5c741ed0a492dbc634cd4b52de80b |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2020-04-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-36d5c741ed0a492dbc634cd4b52de80b2025-08-20T03:52:38ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802020-04-01140410.3855/jidc.12235Purpureocillium lilacinum as unusual cause of pulmonary infection in immunocompromised hostsManuel A Salazar-González0Jorge R Violante-Cumpa1Christian G Alfaro-Rivera2Hiram Villanueva-Lozano3Rogelio de Jesús Treviño-Rangel4Gloria M González5Department of Internal Medicine. Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León. Monterrey, MéxicoDepartment of Internal Medicine. Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León. Monterrey, MéxicoDepartment of Infectious Diseases. Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León. Monterrey, Nuevo León, MéxicoDepartment of Microbiology. Facultad de Medicina, Universidad Autónoma de Nuevo León. Monterrey, Nuevo León, MéxicoDepartment of Microbiology. Facultad de Medicina, Universidad Autónoma de Nuevo León. Monterrey, Nuevo León, MéxicoDepartment of Microbiology. Facultad de Medicina, Universidad Autónoma de Nuevo León. Monterrey, Nuevo León, México Purpureocillium lilacinum (P. lilacinum) is an emergent pathogenic mold that presents more commonly as an ocular infection, cutaneous and/or subcutaneous infections in patients that are usually immunocompromised. A pulmonary presentation is rare, the clinical presentation is fever and cough with radiographic presentation as pleural effusion, single-lung consolidation, and cavitary pulmonary disease. We present a case of a patient with hematologic malignancy with febrile neutropenia; after receiving chemotherapy, the patient developed a pulmonary infection with multiple bilateral consolidations shown in the thoracic computed tomography scan. Fever persisted in spite of the use of wide-spectrum antibiotics and amphotericin. Bronchoalveolar lavage was performed and the samples were cultured, isolating in the Sabouraud Dextrous Agar a filamentous fungi growth with purple colonies that were identified morphologically as P. lilacinum and later it was confirmed by molecular methods. Once the infectious agent was identified, we continued amphotericin and oral voriconazole was added to the treatment with complete resolution of the infection. The report aims to create awareness of this emerging infectious disease, as there is little information concerning the treatment and the prognosis of patients infected by P. lilacinum with a pulmonary presentation. https://jidc.org/index.php/journal/article/view/12235Purpureocillium lilacinumPneumoniafungal infectionmycologyimmunocompromised hostinfectious diseases |
| spellingShingle | Manuel A Salazar-González Jorge R Violante-Cumpa Christian G Alfaro-Rivera Hiram Villanueva-Lozano Rogelio de Jesús Treviño-Rangel Gloria M González Purpureocillium lilacinum as unusual cause of pulmonary infection in immunocompromised hosts Journal of Infection in Developing Countries Purpureocillium lilacinum Pneumonia fungal infection mycology immunocompromised host infectious diseases |
| title | Purpureocillium lilacinum as unusual cause of pulmonary infection in immunocompromised hosts |
| title_full | Purpureocillium lilacinum as unusual cause of pulmonary infection in immunocompromised hosts |
| title_fullStr | Purpureocillium lilacinum as unusual cause of pulmonary infection in immunocompromised hosts |
| title_full_unstemmed | Purpureocillium lilacinum as unusual cause of pulmonary infection in immunocompromised hosts |
| title_short | Purpureocillium lilacinum as unusual cause of pulmonary infection in immunocompromised hosts |
| title_sort | purpureocillium lilacinum as unusual cause of pulmonary infection in immunocompromised hosts |
| topic | Purpureocillium lilacinum Pneumonia fungal infection mycology immunocompromised host infectious diseases |
| url | https://jidc.org/index.php/journal/article/view/12235 |
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