Identification of Anticancer Target Combinations to Treat Pancreatic Cancer and Its Associated Cachexia Using Constraint-Based Modeling

Identification of Anticancer Target Combinations to Treat Pancreatic Cancer and Its Associated Cachexia Using Constraint-Based Modeling

Pancreatic cancer is frequently accompanied by cancer-associated cachexia, a debilitating metabolic syndrome marked by progressive skeletal muscle wasting and systemic metabolic dysfunction. This study presents a systems biology framework to simultaneously identify therapeutic targets for both pancr...

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Bibliographic Details
Main Authors: Feng-Sheng Wang, Ching-Kai Wu, Kuang-Tse Huang
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
constraint-based modeling
cancer metabolism
drug target discovery
biomarker identification
fuzzy optimization
nested hybrid differential evolution
Online Access:https://www.mdpi.com/1420-3049/30/15/3200
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