Long-term outcomes in patients after COVID-19: data from the TARGET-VIP registry
Aim. To assess long-term outcomes within 12 months after hospital treatment of patients with coronavirus disease 2019 (COVID-19) as part of a prospective registry.Material and methods. Outcomes in the posthospital period were assessed in 827 patients diagnosed with COVID-19 (age, 58,0±14,8 years; me...
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«FIRMA «SILICEA» LLC
2022-04-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/4912 |
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| author | M. M. Lukyanov N. P. Kutishenko S. Yu. Martsevich A. A. Pulin E. Yu. Andreenko V. P. Voronina V. A. Dindikova N. A. Dmitrieva O. V. Lerman A. N. Makoveeva E. Yu. Okshina A. S. Sgibneva A. A. Smirnov E. N. Belova V. G. Klyashtorny E. V. Kudryashov O. E. Karpov O. M. Drapkina |
| author_facet | M. M. Lukyanov N. P. Kutishenko S. Yu. Martsevich A. A. Pulin E. Yu. Andreenko V. P. Voronina V. A. Dindikova N. A. Dmitrieva O. V. Lerman A. N. Makoveeva E. Yu. Okshina A. S. Sgibneva A. A. Smirnov E. N. Belova V. G. Klyashtorny E. V. Kudryashov O. E. Karpov O. M. Drapkina |
| author_sort | M. M. Lukyanov |
| collection | DOAJ |
| description | Aim. To assess long-term outcomes within 12 months after hospital treatment of patients with coronavirus disease 2019 (COVID-19) as part of a prospective registry.Material and methods. Outcomes in the posthospital period were assessed in 827 patients diagnosed with COVID-19 (age, 58,0±14,8 years; men, 51,3%). For periods of 30-60 days, 6 and 12 months after discharge from the hospital, cases of death, nonfatal myocardial infarction (MI) and stroke, hospitalization, acute respiratory viral infections/influenza were assessed. The follow-up period was 13,0±1,5 months.Results. During the follow-up period, 35 (4,2%) patients died, 6 (0,73%) and 4 (0,48%) cases of MI and stroke were registered. In addition, 142 (17%) patients were hospitalized, while 217 (26,2%) patients had acute respiratory viral infections/ influenza. Factors of age and length of intensive care unit stay were significantly associated (p<0,001) with the risk of all-cause death (hazard ratio (HR)=1,085 per 1 year of life and HR=6,98, respectively), with the risk of composite endpoint (death, non-fatal MI and stroke): HR=1,081 per 1 year of life and HP=4,47. Of the 35 deaths, 11 (31%) were within the first 30 days of follow-up, and 19 (54%) — 90 days after discharge from the hospital. A higher probability of hospitalization was associated with older age (odds ratio (OR)=1,038; p<0,001), while a higher probability of acute respiratory viral infections/influenza was associated with younger age (OR=0,976 per 1 year of life; p<0,001) and female sex (OR=1,414; p=0,03).Conclusion. A prospective follow-up of 827 patients in the TARGET-VIP registry revealed that 12-month mortality was 4,2%, while more than half of the deaths (54%) were registered in the first 90 days, including 31% — for the first month after discharge from the hospital. The most common events were hospitalizations (17,0%) and acute respiratory viral infections/influenza (26,2%), while the rarest were myocardial infarction (0,73%) and stroke (0,48%). The key factors associated with 12-month mortality in the post-COVID-19 period were older age and intensive care unit stay during the reference hospitalization. A higher readmission rate during the follow-up period was associated with older age, and the prevalence of acute respiratory viral infections /influenza during the follow-up period was associated with younger patients and female sex. |
| format | Article |
| id | doaj-art-36d3be1415c94dc894eb470c985d985c |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2022-04-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-36d3be1415c94dc894eb470c985d985c2025-08-20T03:43:39Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202022-04-0127310.15829/1560-4071-2022-49123519Long-term outcomes in patients after COVID-19: data from the TARGET-VIP registryM. M. Lukyanov0N. P. Kutishenko1S. Yu. Martsevich2A. A. Pulin3E. Yu. Andreenko4V. P. Voronina5V. A. Dindikova6N. A. Dmitrieva7O. V. Lerman8A. N. Makoveeva9E. Yu. Okshina10A. S. Sgibneva11A. A. Smirnov12E. N. Belova13V. G. Klyashtorny14E. V. Kudryashov15O. E. Karpov16O. M. Drapkina17National Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicinePirogov National Medical and Surgical CenterNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicinePirogov National Medical and Surgical CenterNational Medical Research Center for Therapy and Preventive MedicineAim. To assess long-term outcomes within 12 months after hospital treatment of patients with coronavirus disease 2019 (COVID-19) as part of a prospective registry.Material and methods. Outcomes in the posthospital period were assessed in 827 patients diagnosed with COVID-19 (age, 58,0±14,8 years; men, 51,3%). For periods of 30-60 days, 6 and 12 months after discharge from the hospital, cases of death, nonfatal myocardial infarction (MI) and stroke, hospitalization, acute respiratory viral infections/influenza were assessed. The follow-up period was 13,0±1,5 months.Results. During the follow-up period, 35 (4,2%) patients died, 6 (0,73%) and 4 (0,48%) cases of MI and stroke were registered. In addition, 142 (17%) patients were hospitalized, while 217 (26,2%) patients had acute respiratory viral infections/ influenza. Factors of age and length of intensive care unit stay were significantly associated (p<0,001) with the risk of all-cause death (hazard ratio (HR)=1,085 per 1 year of life and HR=6,98, respectively), with the risk of composite endpoint (death, non-fatal MI and stroke): HR=1,081 per 1 year of life and HP=4,47. Of the 35 deaths, 11 (31%) were within the first 30 days of follow-up, and 19 (54%) — 90 days after discharge from the hospital. A higher probability of hospitalization was associated with older age (odds ratio (OR)=1,038; p<0,001), while a higher probability of acute respiratory viral infections/influenza was associated with younger age (OR=0,976 per 1 year of life; p<0,001) and female sex (OR=1,414; p=0,03).Conclusion. A prospective follow-up of 827 patients in the TARGET-VIP registry revealed that 12-month mortality was 4,2%, while more than half of the deaths (54%) were registered in the first 90 days, including 31% — for the first month after discharge from the hospital. The most common events were hospitalizations (17,0%) and acute respiratory viral infections/influenza (26,2%), while the rarest were myocardial infarction (0,73%) and stroke (0,48%). The key factors associated with 12-month mortality in the post-COVID-19 period were older age and intensive care unit stay during the reference hospitalization. A higher readmission rate during the follow-up period was associated with older age, and the prevalence of acute respiratory viral infections /influenza during the follow-up period was associated with younger patients and female sex.https://russjcardiol.elpub.ru/jour/article/view/4912coronavirus infectioncovid-19registryprospective follow-uplongterm outcomescardiovascular diseasechronic noncardiac diseasecomorbidity |
| spellingShingle | M. M. Lukyanov N. P. Kutishenko S. Yu. Martsevich A. A. Pulin E. Yu. Andreenko V. P. Voronina V. A. Dindikova N. A. Dmitrieva O. V. Lerman A. N. Makoveeva E. Yu. Okshina A. S. Sgibneva A. A. Smirnov E. N. Belova V. G. Klyashtorny E. V. Kudryashov O. E. Karpov O. M. Drapkina Long-term outcomes in patients after COVID-19: data from the TARGET-VIP registry Российский кардиологический журнал coronavirus infection covid-19 registry prospective follow-up longterm outcomes cardiovascular disease chronic noncardiac disease comorbidity |
| title | Long-term outcomes in patients after COVID-19: data from the TARGET-VIP registry |
| title_full | Long-term outcomes in patients after COVID-19: data from the TARGET-VIP registry |
| title_fullStr | Long-term outcomes in patients after COVID-19: data from the TARGET-VIP registry |
| title_full_unstemmed | Long-term outcomes in patients after COVID-19: data from the TARGET-VIP registry |
| title_short | Long-term outcomes in patients after COVID-19: data from the TARGET-VIP registry |
| title_sort | long term outcomes in patients after covid 19 data from the target vip registry |
| topic | coronavirus infection covid-19 registry prospective follow-up longterm outcomes cardiovascular disease chronic noncardiac disease comorbidity |
| url | https://russjcardiol.elpub.ru/jour/article/view/4912 |
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