Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl Mercaptotriazoles
Pechmann condensation of ethylacetoacetate with derivatives of phenol by heating in absence of solvent and with montmorillonite clays K-10 afforded coumarin derivatives (1a-e) in good yields which on reaction with thiosemicarbazide in anhydrous pyridine yielded coumarin-quinolinyl mercaptotriazole (...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/365647 |
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| _version_ | 1832562256562356224 |
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| author | Mona A. Hosny Hyam A. Radwan Emtithal A. El-Sawi |
| author_facet | Mona A. Hosny Hyam A. Radwan Emtithal A. El-Sawi |
| author_sort | Mona A. Hosny |
| collection | DOAJ |
| description | Pechmann condensation of ethylacetoacetate with derivatives of phenol by heating in absence of solvent and with montmorillonite clays K-10 afforded coumarin derivatives (1a-e) in good yields which on reaction with thiosemicarbazide in anhydrous pyridine yielded coumarin-quinolinyl mercaptotriazole (2a-e). The latter compounds were evaluated for their antimicrobial and anticancer activities. The newly synthesized compounds were characterized by IR, 1HNMR and mass spectra. |
| format | Article |
| id | doaj-art-36cf0f44200e451c929d09b81af4e177 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-36cf0f44200e451c929d09b81af4e1772025-02-03T01:23:06ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-01941737174510.1155/2012/365647Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl MercaptotriazolesMona A. Hosny0Hyam A. Radwan1Emtithal A. El-Sawi2Department of Chemistry, Faculty of Women for Arts Science and Education, Ain Shams University, Cairo, EgyptDepartment of Chemistry, Faculty of Women for Arts Science and Education, Ain Shams University, Cairo, EgyptDepartment of Chemistry, Faculty of Women for Arts Science and Education, Ain Shams University, Cairo, EgyptPechmann condensation of ethylacetoacetate with derivatives of phenol by heating in absence of solvent and with montmorillonite clays K-10 afforded coumarin derivatives (1a-e) in good yields which on reaction with thiosemicarbazide in anhydrous pyridine yielded coumarin-quinolinyl mercaptotriazole (2a-e). The latter compounds were evaluated for their antimicrobial and anticancer activities. The newly synthesized compounds were characterized by IR, 1HNMR and mass spectra.http://dx.doi.org/10.1155/2012/365647 |
| spellingShingle | Mona A. Hosny Hyam A. Radwan Emtithal A. El-Sawi Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl Mercaptotriazoles E-Journal of Chemistry |
| title | Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl Mercaptotriazoles |
| title_full | Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl Mercaptotriazoles |
| title_fullStr | Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl Mercaptotriazoles |
| title_full_unstemmed | Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl Mercaptotriazoles |
| title_short | Synthesis and Anticancer Activity of Some New Derivatives of Coumarin and Quinolinyl Mercaptotriazoles |
| title_sort | synthesis and anticancer activity of some new derivatives of coumarin and quinolinyl mercaptotriazoles |
| url | http://dx.doi.org/10.1155/2012/365647 |
| work_keys_str_mv | AT monaahosny synthesisandanticanceractivityofsomenewderivativesofcoumarinandquinolinylmercaptotriazoles AT hyamaradwan synthesisandanticanceractivityofsomenewderivativesofcoumarinandquinolinylmercaptotriazoles AT emtithalaelsawi synthesisandanticanceractivityofsomenewderivativesofcoumarinandquinolinylmercaptotriazoles |