Mesenchymal cell-derived exosomes and miR-29a-3p mitigate renal fibrosis and vascular rarefaction after renal ischemia reperfusion injury

Mesenchymal cell-derived exosomes and miR-29a-3p mitigate renal fibrosis and vascular rarefaction after renal ischemia reperfusion injury

Abstract Background Renal fibrosis and vascular rarefaction are significant complications of ischemia/reperfusion (I/R) injury. Human umbilical cord mesenchymal cell-derived exosomes (hucMSC-exos) have shown potential in mitigating these conditions. This study investigates the role of miR-29a-3p in...

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Bibliographic Details
Main Authors: Jing Huang, Lang Shi, Yifei Yang, Fan Zhao, Rengui Chen, Wenliang Liao, Jiefu Zhu, Dingping Yang, Xiongfei Wu, Shangting Han
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cell exosomes
Renal ischemia reperfusion injury
Renal fibrosis
Vascular rarefaction
microRNA
Online Access:https://doi.org/10.1186/s13287-025-04226-4
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