Defining the minimal important difference for the visual analogue scale assessing dyspnea in patients with malignant pleural effusions.
<h4>Background</h4>The minimal important difference (MID) is essential for interpreting the results of randomised controlled trials (RCTs). Despite a number of RCTs in patients with malignant pleural effusions (MPEs) which use the visual analogue scale for dyspnea (VASD) as an outcome me...
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| Format: | Article |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0123798 |
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| author | Eleanor K Mishra John P Corcoran Robert J Hallifax John Stradling Nicholas A Maskell Najib M Rahman |
| author_facet | Eleanor K Mishra John P Corcoran Robert J Hallifax John Stradling Nicholas A Maskell Najib M Rahman |
| author_sort | Eleanor K Mishra |
| collection | DOAJ |
| description | <h4>Background</h4>The minimal important difference (MID) is essential for interpreting the results of randomised controlled trials (RCTs). Despite a number of RCTs in patients with malignant pleural effusions (MPEs) which use the visual analogue scale for dyspnea (VASD) as an outcome measure, the MID has not been established.<h4>Methods</h4>Patients with suspected MPE undergoing a pleural procedure recorded their baseline VASD and their post-procedure VASD (24 hours after the pleural drainage), and in parallel assessed their breathlessness on a 7 point Likert scale.<h4>Findings</h4>The mean decrease in VASD in patients with a MPE reporting a 'small but just worthwhile decrease' in their dyspnea (i.e. equivalent to the MID) was 19mm (95% CI 14-24mm). The mean drainage volume required to produce a change in VASD of 19mm was 760ml.<h4>Interpretation</h4>The mean MID for the VASD in patients with a MPE undergoing a pleural procedure is 19mm (95% CI 14-24mm). Thus choosing an improvement of 19mm in the VASD would be justifiable in the design and analysis of future MPE studies. |
| format | Article |
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| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-36c6b8ad27a0437f93e4e5172cb4f0162025-08-20T03:10:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01104e012379810.1371/journal.pone.0123798Defining the minimal important difference for the visual analogue scale assessing dyspnea in patients with malignant pleural effusions.Eleanor K MishraJohn P CorcoranRobert J HallifaxJohn StradlingNicholas A MaskellNajib M Rahman<h4>Background</h4>The minimal important difference (MID) is essential for interpreting the results of randomised controlled trials (RCTs). Despite a number of RCTs in patients with malignant pleural effusions (MPEs) which use the visual analogue scale for dyspnea (VASD) as an outcome measure, the MID has not been established.<h4>Methods</h4>Patients with suspected MPE undergoing a pleural procedure recorded their baseline VASD and their post-procedure VASD (24 hours after the pleural drainage), and in parallel assessed their breathlessness on a 7 point Likert scale.<h4>Findings</h4>The mean decrease in VASD in patients with a MPE reporting a 'small but just worthwhile decrease' in their dyspnea (i.e. equivalent to the MID) was 19mm (95% CI 14-24mm). The mean drainage volume required to produce a change in VASD of 19mm was 760ml.<h4>Interpretation</h4>The mean MID for the VASD in patients with a MPE undergoing a pleural procedure is 19mm (95% CI 14-24mm). Thus choosing an improvement of 19mm in the VASD would be justifiable in the design and analysis of future MPE studies.https://doi.org/10.1371/journal.pone.0123798 |
| spellingShingle | Eleanor K Mishra John P Corcoran Robert J Hallifax John Stradling Nicholas A Maskell Najib M Rahman Defining the minimal important difference for the visual analogue scale assessing dyspnea in patients with malignant pleural effusions. PLoS ONE |
| title | Defining the minimal important difference for the visual analogue scale assessing dyspnea in patients with malignant pleural effusions. |
| title_full | Defining the minimal important difference for the visual analogue scale assessing dyspnea in patients with malignant pleural effusions. |
| title_fullStr | Defining the minimal important difference for the visual analogue scale assessing dyspnea in patients with malignant pleural effusions. |
| title_full_unstemmed | Defining the minimal important difference for the visual analogue scale assessing dyspnea in patients with malignant pleural effusions. |
| title_short | Defining the minimal important difference for the visual analogue scale assessing dyspnea in patients with malignant pleural effusions. |
| title_sort | defining the minimal important difference for the visual analogue scale assessing dyspnea in patients with malignant pleural effusions |
| url | https://doi.org/10.1371/journal.pone.0123798 |
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