Nanog1 in NTERA-2 and recombinant NanogP8 from somatic cancer cells adopt multiple protein conformations and migrate at multiple M.W species.

Nanog1 in NTERA-2 and recombinant NanogP8 from somatic cancer cells adopt multiple protein conformations and migrate at multiple M.W species.

Human Nanog1 is a 305-amino acid (aa) homeodomain-containing transcription factor critical for the pluripotency of embryonic stem (ES) and embryonal carcinoma (EC) cells. Somatic cancer cells predominantly express a retrogene homolog of Nanog1 called NanogP8, which is ~99% similar to Nanog at the aa...

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Main Authors: Bigang Liu, Mark D Badeaux, Grace Choy, Dhyan Chandra, Irvin Shen, Collene R Jeter, Kiera Rycaj, Chia-Fang Lee, Maria D Person, Can Liu, Yueping Chen, Jianjun Shen, Sung Yun Jung, Jun Qin, Dean G Tang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090615&type=printable
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