Atypical Presentation of Multiple Myeloma: From Heart Failure to Multiple Myeloma
Multiple myeloma (MM) is a hematological malignancy commonly associated with bone pain, hypercalcemia, and renal failure. However, its presentation can occasionally mimic other medical conditions, which may delay diagnosis. This case report describes a patient who was initially diagnosed and treate...
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Universitas Nahdlatul Ulama Surabaya
2024-10-01
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| Series: | Medical and Health Science Journal |
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| Online Access: | https://journal2.unusa.ac.id/index.php/MHSJ/article/view/6068 |
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| author | Ainur Elliana Sohaimi Nur Syazwani Jamhuri Ismail Ibrahim Hotimah Masdan Salim |
| author_facet | Ainur Elliana Sohaimi Nur Syazwani Jamhuri Ismail Ibrahim Hotimah Masdan Salim |
| author_sort | Ainur Elliana Sohaimi |
| collection | DOAJ |
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Multiple myeloma (MM) is a hematological malignancy commonly associated with bone pain, hypercalcemia, and renal failure. However, its presentation can occasionally mimic other medical conditions, which may delay diagnosis. This case report describes a patient who was initially diagnosed and treated for heart failure but was later found to have MM, highlighting the importance of considering MM in the differential diagnosis of heart failure.
A 56-year-old lady presented with recurrent episodes of shortness of breath, orthopnea, paroxysmal nocturnal dypsnea and bilateral lower limb swelling which she had been treated for decompensated heart failure with optimal therapy. She denied any family history of cardiovascular disease personal history of underlying medical condition and was a nonsmoker. This patient was diagnosed with multiple myeloma and probability of concomitant cardiac amyloidosis and commenced on bortezomib, thalidomide and dexamethasone (VTD) regime and standard optimal therapy of heart failure but her condition deteriorated. After a few days of starting chemotherapy, patient demised despite all the resuscitative effort. Multiple myeloma is common hematological malignancy with its distinct clinical features of “CRAB”, however, more attention and alertness should also be exercised by clinicians as to be able to diagnose it early.
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| format | Article |
| id | doaj-art-36be0fa905ab4bcd9944db777f2842d8 |
| institution | OA Journals |
| issn | 2549-7588 2549-7596 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Universitas Nahdlatul Ulama Surabaya |
| record_format | Article |
| series | Medical and Health Science Journal |
| spelling | doaj-art-36be0fa905ab4bcd9944db777f2842d82025-08-20T02:11:30ZengUniversitas Nahdlatul Ulama SurabayaMedical and Health Science Journal2549-75882549-75962024-10-0180210.33086/mhsj.v8i02.6068Atypical Presentation of Multiple Myeloma: From Heart Failure to Multiple MyelomaAinur Elliana Sohaimi0Nur Syazwani Jamhuri1Ismail Ibrahim2Hotimah Masdan Salim3Department of Internal Medicine, Kulliyyah of Medicine, International Islamic University Malaysia, MalaysiaDepartment of Internal Medicine, Kulliyyah of Medicine, International Islamic University Malaysia, MalaysiaDepartment of Internal Medicine, Kulliyyah of Medicine, International Islamic University Malaysia, MalaysiaDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Nahdlatul Ulama Surabaya, Indonesia Multiple myeloma (MM) is a hematological malignancy commonly associated with bone pain, hypercalcemia, and renal failure. However, its presentation can occasionally mimic other medical conditions, which may delay diagnosis. This case report describes a patient who was initially diagnosed and treated for heart failure but was later found to have MM, highlighting the importance of considering MM in the differential diagnosis of heart failure. A 56-year-old lady presented with recurrent episodes of shortness of breath, orthopnea, paroxysmal nocturnal dypsnea and bilateral lower limb swelling which she had been treated for decompensated heart failure with optimal therapy. She denied any family history of cardiovascular disease personal history of underlying medical condition and was a nonsmoker. This patient was diagnosed with multiple myeloma and probability of concomitant cardiac amyloidosis and commenced on bortezomib, thalidomide and dexamethasone (VTD) regime and standard optimal therapy of heart failure but her condition deteriorated. After a few days of starting chemotherapy, patient demised despite all the resuscitative effort. Multiple myeloma is common hematological malignancy with its distinct clinical features of “CRAB”, however, more attention and alertness should also be exercised by clinicians as to be able to diagnose it early. https://journal2.unusa.ac.id/index.php/MHSJ/article/view/6068Multiple myelomacardiac amyloidosissystemic amyloidosisheart failureAL amyloidosis |
| spellingShingle | Ainur Elliana Sohaimi Nur Syazwani Jamhuri Ismail Ibrahim Hotimah Masdan Salim Atypical Presentation of Multiple Myeloma: From Heart Failure to Multiple Myeloma Medical and Health Science Journal Multiple myeloma cardiac amyloidosis systemic amyloidosis heart failure AL amyloidosis |
| title | Atypical Presentation of Multiple Myeloma: From Heart Failure to Multiple Myeloma |
| title_full | Atypical Presentation of Multiple Myeloma: From Heart Failure to Multiple Myeloma |
| title_fullStr | Atypical Presentation of Multiple Myeloma: From Heart Failure to Multiple Myeloma |
| title_full_unstemmed | Atypical Presentation of Multiple Myeloma: From Heart Failure to Multiple Myeloma |
| title_short | Atypical Presentation of Multiple Myeloma: From Heart Failure to Multiple Myeloma |
| title_sort | atypical presentation of multiple myeloma from heart failure to multiple myeloma |
| topic | Multiple myeloma cardiac amyloidosis systemic amyloidosis heart failure AL amyloidosis |
| url | https://journal2.unusa.ac.id/index.php/MHSJ/article/view/6068 |
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