The role of bismuth drugs in elevation of Helicobacter pylori infection eradication efficacy
Aim of review. To demonstrate modern potential of bismuth agents administration for increasing of Helicobacter pylori (H. pylori) eradication efficacy. Summary. Prevention of peptic ulcer and stomach cancer makes eradication of H. pylori infection more and more important. At the same time efficacy o...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2018-08-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/221 |
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| author | A. A. Sheptulin |
| author_facet | A. A. Sheptulin |
| author_sort | A. A. Sheptulin |
| collection | DOAJ |
| description | Aim of review. To demonstrate modern potential of bismuth agents administration for increasing of Helicobacter pylori (H. pylori) eradication efficacy. Summary. Prevention of peptic ulcer and stomach cancer makes eradication of H. pylori infection more and more important. At the same time efficacy of some eradication modes, first of all - that of standard triple therapy, steadily decreases because of growing antibiotic resistance of H. pylori strains, first of all - clarithromycin resistance. The concept that empirical prescription of standard triple therapy should be abandoned in favor of initial H. pylori clarithromycin-resistance testing by culture or real-time polymerase chain reaction became widely accepted. Bismuth-based quadrotherapy mainly - with bismuth tripotassium dicitrate (BTD) is alternative to standard triple mode therapy nowadays. Potential of BTD combination not only to tetracycline but to other antibiotics as well was demonstrated. Addition of BTD to triple therapy containing clarithromycin, levofloxacin, metronidazole allows to increase eradication efficacy for 30-40% at H. pylori-resistant strains. Absence of H. pylori resistance development to BTD, combined antibacterial and cytoprotective effects as well as good tolerance are important advantages of the drug. Conclusion. Addition of BTD to triple H. pylori eradication modes, that include different antibiotics (clarithromycin, levofloxacin and metronidazole) provide significant increase in efficacy of eradication at antibioticresistant Helicobacter pylori strains. |
| format | Article |
| id | doaj-art-36bb986abbf24cf787fd0215f0a5e7d0 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-36bb986abbf24cf787fd0215f0a5e7d02025-02-10T16:14:29ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-08-01281899310.22416/1382-4376-2018-28-1-89-93221The role of bismuth drugs in elevation of Helicobacter pylori infection eradication efficacyA. A. Sheptulin0Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical UniversityAim of review. To demonstrate modern potential of bismuth agents administration for increasing of Helicobacter pylori (H. pylori) eradication efficacy. Summary. Prevention of peptic ulcer and stomach cancer makes eradication of H. pylori infection more and more important. At the same time efficacy of some eradication modes, first of all - that of standard triple therapy, steadily decreases because of growing antibiotic resistance of H. pylori strains, first of all - clarithromycin resistance. The concept that empirical prescription of standard triple therapy should be abandoned in favor of initial H. pylori clarithromycin-resistance testing by culture or real-time polymerase chain reaction became widely accepted. Bismuth-based quadrotherapy mainly - with bismuth tripotassium dicitrate (BTD) is alternative to standard triple mode therapy nowadays. Potential of BTD combination not only to tetracycline but to other antibiotics as well was demonstrated. Addition of BTD to triple therapy containing clarithromycin, levofloxacin, metronidazole allows to increase eradication efficacy for 30-40% at H. pylori-resistant strains. Absence of H. pylori resistance development to BTD, combined antibacterial and cytoprotective effects as well as good tolerance are important advantages of the drug. Conclusion. Addition of BTD to triple H. pylori eradication modes, that include different antibiotics (clarithromycin, levofloxacin and metronidazole) provide significant increase in efficacy of eradication at antibioticresistant Helicobacter pylori strains.https://www.gastro-j.ru/jour/article/view/221helicobacter pyloriэрадикациярезистентностьвисмута трикалия дицитрат |
| spellingShingle | A. A. Sheptulin The role of bismuth drugs in elevation of Helicobacter pylori infection eradication efficacy Российский журнал гастроэнтерологии, гепатологии, колопроктологии helicobacter pylori эрадикация резистентность висмута трикалия дицитрат |
| title | The role of bismuth drugs in elevation of Helicobacter pylori infection eradication efficacy |
| title_full | The role of bismuth drugs in elevation of Helicobacter pylori infection eradication efficacy |
| title_fullStr | The role of bismuth drugs in elevation of Helicobacter pylori infection eradication efficacy |
| title_full_unstemmed | The role of bismuth drugs in elevation of Helicobacter pylori infection eradication efficacy |
| title_short | The role of bismuth drugs in elevation of Helicobacter pylori infection eradication efficacy |
| title_sort | role of bismuth drugs in elevation of helicobacter pylori infection eradication efficacy |
| topic | helicobacter pylori эрадикация резистентность висмута трикалия дицитрат |
| url | https://www.gastro-j.ru/jour/article/view/221 |
| work_keys_str_mv | AT aasheptulin theroleofbismuthdrugsinelevationofhelicobacterpyloriinfectioneradicationefficacy AT aasheptulin roleofbismuthdrugsinelevationofhelicobacterpyloriinfectioneradicationefficacy |