A Unique Presentation of Cutaneous Diffuse Large B-Cell Lymphoma

Cutaneous B-cell lymphomas (CBCL) are rare heterogeneous neoplastic diseases composing about 22.5% of all cutaneous lymphomas. These diseases can be divided into primary and secondary cutaneous variants with primary cutaneous B-cell lymphoma (PCBCL) divided into three distinct entities including pri...

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Main Authors: Mary Awad, Erik Holzwanger, Sandeep Jubbal
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Case Reports in Dermatological Medicine
Online Access:http://dx.doi.org/10.1155/2020/8310602
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author Mary Awad
Erik Holzwanger
Sandeep Jubbal
author_facet Mary Awad
Erik Holzwanger
Sandeep Jubbal
author_sort Mary Awad
collection DOAJ
description Cutaneous B-cell lymphomas (CBCL) are rare heterogeneous neoplastic diseases composing about 22.5% of all cutaneous lymphomas. These diseases can be divided into primary and secondary cutaneous variants with primary cutaneous B-cell lymphoma (PCBCL) divided into three distinct entities including primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT). Secondary cutaneous diffuse large B-cell lymphoma (CDLBCL) and PCDLBCL, LT are more aggressive neoplasms compared to the aforementioned CBCL with survival rates of 37% and 50% after 5 years, respectively. CDLBCL can present as cutaneous or subcutaneous nodules, papular lesions, or indurated plaques. Here, we present a case of CDLBCL of an 88-year-old female that was mistaken for lower extremity cellulitis with phlegmon. Our patient failed two courses of antibiotic therapy as an outpatient and received a third as an inpatient before a cutaneous biopsy clinched the diagnosis.
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series Case Reports in Dermatological Medicine
spelling doaj-art-36b77fd5474741d7b204f2b8bd71fb7e2025-08-20T03:55:02ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712020-01-01202010.1155/2020/83106028310602A Unique Presentation of Cutaneous Diffuse Large B-Cell LymphomaMary Awad0Erik Holzwanger1Sandeep Jubbal2University of Massachusetts Medical School, Worcester, MA, USAUniversity of Massachusetts Medical School, Worcester, MA, USAUniversity of Massachusetts Medical School, Worcester, MA, USACutaneous B-cell lymphomas (CBCL) are rare heterogeneous neoplastic diseases composing about 22.5% of all cutaneous lymphomas. These diseases can be divided into primary and secondary cutaneous variants with primary cutaneous B-cell lymphoma (PCBCL) divided into three distinct entities including primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT). Secondary cutaneous diffuse large B-cell lymphoma (CDLBCL) and PCDLBCL, LT are more aggressive neoplasms compared to the aforementioned CBCL with survival rates of 37% and 50% after 5 years, respectively. CDLBCL can present as cutaneous or subcutaneous nodules, papular lesions, or indurated plaques. Here, we present a case of CDLBCL of an 88-year-old female that was mistaken for lower extremity cellulitis with phlegmon. Our patient failed two courses of antibiotic therapy as an outpatient and received a third as an inpatient before a cutaneous biopsy clinched the diagnosis.http://dx.doi.org/10.1155/2020/8310602
spellingShingle Mary Awad
Erik Holzwanger
Sandeep Jubbal
A Unique Presentation of Cutaneous Diffuse Large B-Cell Lymphoma
Case Reports in Dermatological Medicine
title A Unique Presentation of Cutaneous Diffuse Large B-Cell Lymphoma
title_full A Unique Presentation of Cutaneous Diffuse Large B-Cell Lymphoma
title_fullStr A Unique Presentation of Cutaneous Diffuse Large B-Cell Lymphoma
title_full_unstemmed A Unique Presentation of Cutaneous Diffuse Large B-Cell Lymphoma
title_short A Unique Presentation of Cutaneous Diffuse Large B-Cell Lymphoma
title_sort unique presentation of cutaneous diffuse large b cell lymphoma
url http://dx.doi.org/10.1155/2020/8310602
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AT sandeepjubbal auniquepresentationofcutaneousdiffuselargebcelllymphoma
AT maryawad uniquepresentationofcutaneousdiffuselargebcelllymphoma
AT erikholzwanger uniquepresentationofcutaneousdiffuselargebcelllymphoma
AT sandeepjubbal uniquepresentationofcutaneousdiffuselargebcelllymphoma