Design of Spatial pore structures in Micro-Arc oxidation coatings of Ti implant for nanoparticle drug delivery
Medical titanium alloy implants, with insufficient antibacterial and wear-resistant properties, can lead to implant-associated infections (IAI), reducing their lifespan. Thus, developing surface coatings with both antibacterial and wear-resistant properties is crucial. In this study, MAO coatings we...
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Elsevier
2025-06-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127525004125 |
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| author | Shuangshuang Zhang Wei Shi Fei Liu Song Xiang |
| author_facet | Shuangshuang Zhang Wei Shi Fei Liu Song Xiang |
| author_sort | Shuangshuang Zhang |
| collection | DOAJ |
| description | Medical titanium alloy implants, with insufficient antibacterial and wear-resistant properties, can lead to implant-associated infections (IAI), reducing their lifespan. Thus, developing surface coatings with both antibacterial and wear-resistant properties is crucial. In this study, MAO coatings were fabricated at different voltages, and their wear resistance was systematically evaluated. Drug-loaded mesoporous silica nanoparticles were integrated into the MAO coating structure to develop drug-loaded coatings, and the drug release behavior was investigated under both static and wear conditions. The results demonstrated that MAO coatings fabricated at higher voltages exhibited denser pore structures, increased thickness, and enhanced wear resistance. Notably, the coating prepared at 360 V showed superior pore interconnectivity, which facilitated efficient drug loading and sustained release during wear. These findings provide valuable insights for the design of wear-resistant and antibacterial coatings for titanium alloy implants. |
| format | Article |
| id | doaj-art-36b7754aa15649bfa9ff3a9fddc72a2d |
| institution | Kabale University |
| issn | 0264-1275 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj-art-36b7754aa15649bfa9ff3a9fddc72a2d2025-08-20T03:46:47ZengElsevierMaterials & Design0264-12752025-06-0125411399210.1016/j.matdes.2025.113992Design of Spatial pore structures in Micro-Arc oxidation coatings of Ti implant for nanoparticle drug deliveryShuangshuang Zhang0Wei Shi1Fei Liu2Song Xiang3Guizhou Key Laboratory of Materials Mechanical Behavior and Microstructure, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, PR ChinaCorresponding authors.; Guizhou Key Laboratory of Materials Mechanical Behavior and Microstructure, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, PR ChinaCorresponding authors.; Guizhou Key Laboratory of Materials Mechanical Behavior and Microstructure, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, PR ChinaGuizhou Key Laboratory of Materials Mechanical Behavior and Microstructure, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, PR ChinaMedical titanium alloy implants, with insufficient antibacterial and wear-resistant properties, can lead to implant-associated infections (IAI), reducing their lifespan. Thus, developing surface coatings with both antibacterial and wear-resistant properties is crucial. In this study, MAO coatings were fabricated at different voltages, and their wear resistance was systematically evaluated. Drug-loaded mesoporous silica nanoparticles were integrated into the MAO coating structure to develop drug-loaded coatings, and the drug release behavior was investigated under both static and wear conditions. The results demonstrated that MAO coatings fabricated at higher voltages exhibited denser pore structures, increased thickness, and enhanced wear resistance. Notably, the coating prepared at 360 V showed superior pore interconnectivity, which facilitated efficient drug loading and sustained release during wear. These findings provide valuable insights for the design of wear-resistant and antibacterial coatings for titanium alloy implants.http://www.sciencedirect.com/science/article/pii/S0264127525004125Titanium alloyMicro-arc oxidationDrug-loadedWear resistance |
| spellingShingle | Shuangshuang Zhang Wei Shi Fei Liu Song Xiang Design of Spatial pore structures in Micro-Arc oxidation coatings of Ti implant for nanoparticle drug delivery Materials & Design Titanium alloy Micro-arc oxidation Drug-loaded Wear resistance |
| title | Design of Spatial pore structures in Micro-Arc oxidation coatings of Ti implant for nanoparticle drug delivery |
| title_full | Design of Spatial pore structures in Micro-Arc oxidation coatings of Ti implant for nanoparticle drug delivery |
| title_fullStr | Design of Spatial pore structures in Micro-Arc oxidation coatings of Ti implant for nanoparticle drug delivery |
| title_full_unstemmed | Design of Spatial pore structures in Micro-Arc oxidation coatings of Ti implant for nanoparticle drug delivery |
| title_short | Design of Spatial pore structures in Micro-Arc oxidation coatings of Ti implant for nanoparticle drug delivery |
| title_sort | design of spatial pore structures in micro arc oxidation coatings of ti implant for nanoparticle drug delivery |
| topic | Titanium alloy Micro-arc oxidation Drug-loaded Wear resistance |
| url | http://www.sciencedirect.com/science/article/pii/S0264127525004125 |
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