Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic Delivery
ABSTRACT Platelets play a pivotal role in cancer detection and metastasis, serving both as novel liquid biopsy biomarkers and as versatile carriers in nanomedicine. Tumor‐educated platelets (TEPs) undergo molecular alterations influenced by the tumor microenvironment, with their RNA profiles—includi...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | MedComm – Biomaterials and Applications |
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| Online Access: | https://doi.org/10.1002/mba2.70010 |
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| author | Xin Wang Jie Chen Hubing Shi |
| author_facet | Xin Wang Jie Chen Hubing Shi |
| author_sort | Xin Wang |
| collection | DOAJ |
| description | ABSTRACT Platelets play a pivotal role in cancer detection and metastasis, serving both as novel liquid biopsy biomarkers and as versatile carriers in nanomedicine. Tumor‐educated platelets (TEPs) undergo molecular alterations influenced by the tumor microenvironment, with their RNA profiles—including mRNA, circular RNA, and long noncoding RNA—offering potential for early cancer detection, prognosis, and treatment monitoring. Additionally, platelet‐derived extracellular vesicles (PEVs) and activation markers (e.g., P‐selectin, CD40L) further enhance their diagnostic utility. However, standardization of platelet biomarker analysis remains a challenge for clinical implementation. Concurrently, nanotechnology is leveraging the natural biocompatibility and targeting properties of platelets to develop platelet‐based drug delivery systems and bioinspired nanomaterials, improving therapeutic precision and efficacy. Moreover, artificial intelligence (AI)‐driven biomarker analysis is refining TEP and PEV profiling, accelerating advances in precision oncology. Future research should focus on establishing standardized protocols, optimizing platelet‐based nanomedicine, and integrating AI to enhance diagnostic accuracy and therapeutic efficacy. By bridging biological insights with clinical applications, platelets hold significant promise as transformative tools in precision oncology. |
| format | Article |
| id | doaj-art-36b3fbc0ce7440c49aa5e27fecab2b26 |
| institution | DOAJ |
| issn | 2769-643X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm – Biomaterials and Applications |
| spelling | doaj-art-36b3fbc0ce7440c49aa5e27fecab2b262025-08-20T03:23:27ZengWileyMedComm – Biomaterials and Applications2769-643X2025-06-0142n/an/a10.1002/mba2.70010Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic DeliveryXin Wang0Jie Chen1Hubing Shi2Institute for Breast Health Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center Chengdu Sichuan ChinaBreast Center, West China Hospital, Sichuan University Chengdu Sichuan ChinaInstitute for Breast Health Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center Chengdu Sichuan ChinaABSTRACT Platelets play a pivotal role in cancer detection and metastasis, serving both as novel liquid biopsy biomarkers and as versatile carriers in nanomedicine. Tumor‐educated platelets (TEPs) undergo molecular alterations influenced by the tumor microenvironment, with their RNA profiles—including mRNA, circular RNA, and long noncoding RNA—offering potential for early cancer detection, prognosis, and treatment monitoring. Additionally, platelet‐derived extracellular vesicles (PEVs) and activation markers (e.g., P‐selectin, CD40L) further enhance their diagnostic utility. However, standardization of platelet biomarker analysis remains a challenge for clinical implementation. Concurrently, nanotechnology is leveraging the natural biocompatibility and targeting properties of platelets to develop platelet‐based drug delivery systems and bioinspired nanomaterials, improving therapeutic precision and efficacy. Moreover, artificial intelligence (AI)‐driven biomarker analysis is refining TEP and PEV profiling, accelerating advances in precision oncology. Future research should focus on establishing standardized protocols, optimizing platelet‐based nanomedicine, and integrating AI to enhance diagnostic accuracy and therapeutic efficacy. By bridging biological insights with clinical applications, platelets hold significant promise as transformative tools in precision oncology.https://doi.org/10.1002/mba2.70010circulating tumor cellsdiagnoseplatelet‐based nanomaterialsplateletstumor‐educated platelets |
| spellingShingle | Xin Wang Jie Chen Hubing Shi Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic Delivery MedComm – Biomaterials and Applications circulating tumor cells diagnose platelet‐based nanomaterials platelets tumor‐educated platelets |
| title | Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic Delivery |
| title_full | Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic Delivery |
| title_fullStr | Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic Delivery |
| title_full_unstemmed | Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic Delivery |
| title_short | Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic Delivery |
| title_sort | platelets novel biomaterials for cancer diagnosis and therapeutic delivery |
| topic | circulating tumor cells diagnose platelet‐based nanomaterials platelets tumor‐educated platelets |
| url | https://doi.org/10.1002/mba2.70010 |
| work_keys_str_mv | AT xinwang plateletsnovelbiomaterialsforcancerdiagnosisandtherapeuticdelivery AT jiechen plateletsnovelbiomaterialsforcancerdiagnosisandtherapeuticdelivery AT hubingshi plateletsnovelbiomaterialsforcancerdiagnosisandtherapeuticdelivery |