Antioxidant-mediated suppression of ferroptosis in Pyricularia oryzae: a novel approach to rice blast management for sustainable rice production
Ferroptosis, an iron-dependent form of regulated cell death, has recently emerged as a crucial process in the pathogenesis of Pyricularia oryzae, the causal agent of the devastating rice blast disease, which causes billions of dollars in annual losses. This mini review explores the potential of anti...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-12-01
|
| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpls.2024.1520688/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850054628211687424 |
|---|---|
| author | Mattia Santoni Junior Bernardo Molina-Hernandez Andrea Kunova Paolo Cortesi Barbara Brunetti Pietro Rocculi Pietro Rocculi Michael S. Christodoulou Francesca Danesi Francesca Danesi |
| author_facet | Mattia Santoni Junior Bernardo Molina-Hernandez Andrea Kunova Paolo Cortesi Barbara Brunetti Pietro Rocculi Pietro Rocculi Michael S. Christodoulou Francesca Danesi Francesca Danesi |
| author_sort | Mattia Santoni |
| collection | DOAJ |
| description | Ferroptosis, an iron-dependent form of regulated cell death, has recently emerged as a crucial process in the pathogenesis of Pyricularia oryzae, the causal agent of the devastating rice blast disease, which causes billions of dollars in annual losses. This mini review explores the potential of antioxidants in suppressing ferroptosis in P. oryzae to promote sustainable rice production, with significant implications for global food security and nutrition. We critically analyze the current literature on the mechanisms of ferroptosis in P. oryzae, including iron metabolism and lipid peroxidation, the role of different antioxidants in inhibiting this cell death pathway, and the potential applications of antioxidant-based strategies for the management of rice blast disease. Recent discoveries, such as the efficacy of the natural flavonoid tangeretin in inhibiting fungal ferroptosis by interfering with the accumulation of iron and reactive oxygen species, highlight the promise of natural and nature-inspired compounds for disease management. The use of antioxidants to modulate ferroptosis in P. oryzae offers several advantages over traditional fungicide-based approaches, including improved safety, sustainability, and potential nutritional benefits through antioxidant-enriched rice varieties. However, challenges such as optimizing delivery methods, managing potential resistance, and ensuring efficacy under different environmental conditions need to be addressed. To achieve these goals, future research should focus on identifying the most effective antioxidant compounds, exploring synergistic combinations, and developing sustainable application methods. |
| format | Article |
| id | doaj-art-36b3c71e82ca4c1ea8fb51c52e20b05b |
| institution | DOAJ |
| issn | 1664-462X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj-art-36b3c71e82ca4c1ea8fb51c52e20b05b2025-08-20T02:52:12ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2024-12-011510.3389/fpls.2024.15206881520688Antioxidant-mediated suppression of ferroptosis in Pyricularia oryzae: a novel approach to rice blast management for sustainable rice productionMattia Santoni0Junior Bernardo Molina-Hernandez1Andrea Kunova2Paolo Cortesi3Barbara Brunetti4Pietro Rocculi5Pietro Rocculi6Michael S. Christodoulou7Francesca Danesi8Francesca Danesi9Department of Agricultural and Food Sciences (DISTAL), University of Bologna, Cesena, ItalyDepartment of Agricultural and Food Sciences (DISTAL), University of Bologna, Cesena, ItalyDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, ItalyDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, ItalyDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, ItalyDepartment of Agricultural and Food Sciences (DISTAL), University of Bologna, Cesena, ItalyInterdepartmental Centre for Industrial Agri-Food Research (CIRI), University of Bologna, Cesena, ItalyDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, ItalyDepartment of Agricultural and Food Sciences (DISTAL), University of Bologna, Cesena, ItalyInterdepartmental Centre for Industrial Agri-Food Research (CIRI), University of Bologna, Cesena, ItalyFerroptosis, an iron-dependent form of regulated cell death, has recently emerged as a crucial process in the pathogenesis of Pyricularia oryzae, the causal agent of the devastating rice blast disease, which causes billions of dollars in annual losses. This mini review explores the potential of antioxidants in suppressing ferroptosis in P. oryzae to promote sustainable rice production, with significant implications for global food security and nutrition. We critically analyze the current literature on the mechanisms of ferroptosis in P. oryzae, including iron metabolism and lipid peroxidation, the role of different antioxidants in inhibiting this cell death pathway, and the potential applications of antioxidant-based strategies for the management of rice blast disease. Recent discoveries, such as the efficacy of the natural flavonoid tangeretin in inhibiting fungal ferroptosis by interfering with the accumulation of iron and reactive oxygen species, highlight the promise of natural and nature-inspired compounds for disease management. The use of antioxidants to modulate ferroptosis in P. oryzae offers several advantages over traditional fungicide-based approaches, including improved safety, sustainability, and potential nutritional benefits through antioxidant-enriched rice varieties. However, challenges such as optimizing delivery methods, managing potential resistance, and ensuring efficacy under different environmental conditions need to be addressed. To achieve these goals, future research should focus on identifying the most effective antioxidant compounds, exploring synergistic combinations, and developing sustainable application methods.https://www.frontiersin.org/articles/10.3389/fpls.2024.1520688/fullantioxidantsferroptosisMagnaporthe oryzaeperoxidationplant-pathogen interactionsPyricularia oryzae |
| spellingShingle | Mattia Santoni Junior Bernardo Molina-Hernandez Andrea Kunova Paolo Cortesi Barbara Brunetti Pietro Rocculi Pietro Rocculi Michael S. Christodoulou Francesca Danesi Francesca Danesi Antioxidant-mediated suppression of ferroptosis in Pyricularia oryzae: a novel approach to rice blast management for sustainable rice production Frontiers in Plant Science antioxidants ferroptosis Magnaporthe oryzae peroxidation plant-pathogen interactions Pyricularia oryzae |
| title | Antioxidant-mediated suppression of ferroptosis in Pyricularia oryzae: a novel approach to rice blast management for sustainable rice production |
| title_full | Antioxidant-mediated suppression of ferroptosis in Pyricularia oryzae: a novel approach to rice blast management for sustainable rice production |
| title_fullStr | Antioxidant-mediated suppression of ferroptosis in Pyricularia oryzae: a novel approach to rice blast management for sustainable rice production |
| title_full_unstemmed | Antioxidant-mediated suppression of ferroptosis in Pyricularia oryzae: a novel approach to rice blast management for sustainable rice production |
| title_short | Antioxidant-mediated suppression of ferroptosis in Pyricularia oryzae: a novel approach to rice blast management for sustainable rice production |
| title_sort | antioxidant mediated suppression of ferroptosis in pyricularia oryzae a novel approach to rice blast management for sustainable rice production |
| topic | antioxidants ferroptosis Magnaporthe oryzae peroxidation plant-pathogen interactions Pyricularia oryzae |
| url | https://www.frontiersin.org/articles/10.3389/fpls.2024.1520688/full |
| work_keys_str_mv | AT mattiasantoni antioxidantmediatedsuppressionofferroptosisinpyriculariaoryzaeanovelapproachtoriceblastmanagementforsustainablericeproduction AT juniorbernardomolinahernandez antioxidantmediatedsuppressionofferroptosisinpyriculariaoryzaeanovelapproachtoriceblastmanagementforsustainablericeproduction AT andreakunova antioxidantmediatedsuppressionofferroptosisinpyriculariaoryzaeanovelapproachtoriceblastmanagementforsustainablericeproduction AT paolocortesi antioxidantmediatedsuppressionofferroptosisinpyriculariaoryzaeanovelapproachtoriceblastmanagementforsustainablericeproduction AT barbarabrunetti antioxidantmediatedsuppressionofferroptosisinpyriculariaoryzaeanovelapproachtoriceblastmanagementforsustainablericeproduction AT pietrorocculi antioxidantmediatedsuppressionofferroptosisinpyriculariaoryzaeanovelapproachtoriceblastmanagementforsustainablericeproduction AT pietrorocculi antioxidantmediatedsuppressionofferroptosisinpyriculariaoryzaeanovelapproachtoriceblastmanagementforsustainablericeproduction AT michaelschristodoulou antioxidantmediatedsuppressionofferroptosisinpyriculariaoryzaeanovelapproachtoriceblastmanagementforsustainablericeproduction AT francescadanesi antioxidantmediatedsuppressionofferroptosisinpyriculariaoryzaeanovelapproachtoriceblastmanagementforsustainablericeproduction AT francescadanesi antioxidantmediatedsuppressionofferroptosisinpyriculariaoryzaeanovelapproachtoriceblastmanagementforsustainablericeproduction |