Features of Isotypic Structure of Virus-Specific Systemic Humoral Immune Response in Adult Volunteers Immunized with Inactivated Monovalent Subunit Vaccines against Pandemic Influenza A(H1N1)pdm09
An isotypic structure of system antibody response to influenza A(H1N1)pdm09 was analyzed in adult volunteers vaccinated with two inactivated monovalent subunit vaccines against pandemic influenza. The comparison group consisted of patients infected with influenza A(H1N1)pdm09 virus. In vaccinated vo...
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2016-04-01
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| Series: | Эпидемиология и вакцинопрофилактика |
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| Online Access: | https://www.epidemvac.ru/jour/article/view/153 |
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| author | A. A. Vasileva V. Z. Krivitskaya E. M. Vojcekhovskaya V. S. Vakin E. V. Kuznecova E. R. Petrova A. A. Go N. I. Lvov A. A. Sominina |
| author_facet | A. A. Vasileva V. Z. Krivitskaya E. M. Vojcekhovskaya V. S. Vakin E. V. Kuznecova E. R. Petrova A. A. Go N. I. Lvov A. A. Sominina |
| author_sort | A. A. Vasileva |
| collection | DOAJ |
| description | An isotypic structure of system antibody response to influenza A(H1N1)pdm09 was analyzed in adult volunteers vaccinated with two inactivated monovalent subunit vaccines against pandemic influenza. The comparison group consisted of patients infected with influenza A(H1N1)pdm09 virus. In vaccinated volunteers the more active response of influenza-specific antibodies both with neutralizing properties (IgG1, IgG2, IgG3) and associated with allergic inflammation (IgG and IgE) was observed in comparison with infected patients. The high activity of the virus-specific serum IgA was observed both in infected patients and vaccinated volunteers. Antiviral hemagglutinating activity of antibodies in post-vaccination sera of vaccinated volunteers, unlike sera obtained from infected patients in the phase of recovery, were higher than protective level (1:40) according to HAI data. |
| format | Article |
| id | doaj-art-36ad4840b6bc4d4bb6412cf85929dae3 |
| institution | Kabale University |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| publishDate | 2016-04-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj-art-36ad4840b6bc4d4bb6412cf85929dae32025-08-20T03:57:18ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942016-04-01152778410.31631/2073-3046-2016-15-2-77-84152Features of Isotypic Structure of Virus-Specific Systemic Humoral Immune Response in Adult Volunteers Immunized with Inactivated Monovalent Subunit Vaccines against Pandemic Influenza A(H1N1)pdm09A. A. Vasileva0V. Z. Krivitskaya1E. M. Vojcekhovskaya2V. S. Vakin3E. V. Kuznecova4E. R. Petrova5A. A. Go6N. I. Lvov7A. A. Sominina8The Federal State Budgetary Institution «Research Influenza Institute» of Ministry of Healthcare of the Russian FederationThe Federal State Budgetary Institution «Research Influenza Institute» of Ministry of Healthcare of the Russian FederationThe Federal State Budgetary Institution «Research Influenza Institute» of Ministry of Healthcare of the Russian FederationThe Federal State Budgetary Institution «Research Influenza Institute» of Ministry of Healthcare of the Russian FederationThe Federal State Budgetary Institution «Research Influenza Institute» of Ministry of Healthcare of the Russian FederationThe Federal State Budgetary Institution «Research Influenza Institute» of Ministry of Healthcare of the Russian FederationThe Federal State Budgetary Institution «Research Influenza Institute» of Ministry of Healthcare of the Russian FederationFederal State Military Educational Institution of Additional Professional Education «Military Medical Academy named S.M. Kirov» Ministry of Defense of the Russian FederationThe Federal State Budgetary Institution «Research Influenza Institute» of Ministry of Healthcare of the Russian FederationAn isotypic structure of system antibody response to influenza A(H1N1)pdm09 was analyzed in adult volunteers vaccinated with two inactivated monovalent subunit vaccines against pandemic influenza. The comparison group consisted of patients infected with influenza A(H1N1)pdm09 virus. In vaccinated volunteers the more active response of influenza-specific antibodies both with neutralizing properties (IgG1, IgG2, IgG3) and associated with allergic inflammation (IgG and IgE) was observed in comparison with infected patients. The high activity of the virus-specific serum IgA was observed both in infected patients and vaccinated volunteers. Antiviral hemagglutinating activity of antibodies in post-vaccination sera of vaccinated volunteers, unlike sera obtained from infected patients in the phase of recovery, were higher than protective level (1:40) according to HAI data.https://www.epidemvac.ru/jour/article/view/153инактивированные гриппозные вакциныпандемический грипп a(h1n1)pdm09гуморальный иммунитетизотипы иммуноглобулиноввзрослые волонтерыпереболевшие гриппом пациентыinactivated influenza vaccinespandemic influenza a(h1n1)pdm09humoral immunityimmunoglobulin isotypesadult volunteersrecover from influenza patients |
| spellingShingle | A. A. Vasileva V. Z. Krivitskaya E. M. Vojcekhovskaya V. S. Vakin E. V. Kuznecova E. R. Petrova A. A. Go N. I. Lvov A. A. Sominina Features of Isotypic Structure of Virus-Specific Systemic Humoral Immune Response in Adult Volunteers Immunized with Inactivated Monovalent Subunit Vaccines against Pandemic Influenza A(H1N1)pdm09 Эпидемиология и вакцинопрофилактика инактивированные гриппозные вакцины пандемический грипп a(h1n1)pdm09 гуморальный иммунитет изотипы иммуноглобулинов взрослые волонтеры переболевшие гриппом пациенты inactivated influenza vaccines pandemic influenza a(h1n1)pdm09 humoral immunity immunoglobulin isotypes adult volunteers recover from influenza patients |
| title | Features of Isotypic Structure of Virus-Specific Systemic Humoral Immune Response in Adult Volunteers Immunized with Inactivated Monovalent Subunit Vaccines against Pandemic Influenza A(H1N1)pdm09 |
| title_full | Features of Isotypic Structure of Virus-Specific Systemic Humoral Immune Response in Adult Volunteers Immunized with Inactivated Monovalent Subunit Vaccines against Pandemic Influenza A(H1N1)pdm09 |
| title_fullStr | Features of Isotypic Structure of Virus-Specific Systemic Humoral Immune Response in Adult Volunteers Immunized with Inactivated Monovalent Subunit Vaccines against Pandemic Influenza A(H1N1)pdm09 |
| title_full_unstemmed | Features of Isotypic Structure of Virus-Specific Systemic Humoral Immune Response in Adult Volunteers Immunized with Inactivated Monovalent Subunit Vaccines against Pandemic Influenza A(H1N1)pdm09 |
| title_short | Features of Isotypic Structure of Virus-Specific Systemic Humoral Immune Response in Adult Volunteers Immunized with Inactivated Monovalent Subunit Vaccines against Pandemic Influenza A(H1N1)pdm09 |
| title_sort | features of isotypic structure of virus specific systemic humoral immune response in adult volunteers immunized with inactivated monovalent subunit vaccines against pandemic influenza a h1n1 pdm09 |
| topic | инактивированные гриппозные вакцины пандемический грипп a(h1n1)pdm09 гуморальный иммунитет изотипы иммуноглобулинов взрослые волонтеры переболевшие гриппом пациенты inactivated influenza vaccines pandemic influenza a(h1n1)pdm09 humoral immunity immunoglobulin isotypes adult volunteers recover from influenza patients |
| url | https://www.epidemvac.ru/jour/article/view/153 |
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