Association between urinary metal concentrations and hyperuricemia in Chinese community-dwelling elderly: Exploring the mediating role of estimating glomerular filtration rate
Background: It has been shown that multiple metals exposure is associated with hyperuricemia. However, previous studies on the association and interaction between multiple metals exposure and hyperuricemia have been controversial, and there has been little evaluation of the potential mediating role...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325002799 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850053748502560768 |
|---|---|
| author | Zeyang Bai Yuqing Dai Siyu Duan Zhongyuan Zhang Zhuoheng Shen Meiyan Li Limeng Xiong Jinhao Jia Yi Zhao Yihong Di Huifang Yang Jian Sun Rui Zhang |
| author_facet | Zeyang Bai Yuqing Dai Siyu Duan Zhongyuan Zhang Zhuoheng Shen Meiyan Li Limeng Xiong Jinhao Jia Yi Zhao Yihong Di Huifang Yang Jian Sun Rui Zhang |
| author_sort | Zeyang Bai |
| collection | DOAJ |
| description | Background: It has been shown that multiple metals exposure is associated with hyperuricemia. However, previous studies on the association and interaction between multiple metals exposure and hyperuricemia have been controversial, and there has been little evaluation of the potential mediating role of estimating glomerular filtration rate (eGFR). Methods: In this study, levels of 12 metals in the urine of 3756 study participants were measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). The associations between urinary metals and the hyperuricemia were analyzed by multivariable logistic regression model and restricted cubic spline (RCS). Weighted Quantile Sum (WQS) regression was used to explore the weight of each metal. Bayesian Kernel Machine Regression (BKMR) was used to explore the join effect of mixed metal exposure. Mediation analysis was used to explore the role of eGFR in relationship between urinary metal concentration and hyperuricemia. Results: In the multi-metal model, the multivariate-adjusted odds ratio (OR) and 95 % confidence interval (CI) of hyperuricemia were 0.89 (0.81,0.99) for Fe, 0.79 (0.70,0.89) for Se, 0.84 (0.75,0.93) for Cd, 0.87 (0.79,0.96) for Pb, 1.36 (1.23,1.51) for Zn (all P < 0.05). The RCS regression indicated signification nonlinear associations for Zn and Pb (all P-non-linear <0.05). The WQS regression model based on the negative fit showed that the maximum weight of Cd is 43.1 %. In the BKMR model, metal mixtures showed an overall negative association with the risk of developing hyperuricemia, and we also found interactions between Zn and Pb. Mediation analysis showed that eGFR mediated the association between Fe, Se, Cd, Pb and hyperuricemia with mediation ratios of 11.18 %, 12.10 %, 9.60 %, and 12.01 %, respectively. Conclusions: The metal mixture in urine is negatively correlated with hyperuricemia, with Cd having the greatest impact. eGFR may play a partial role in association of Fe, Se, Cd and Pb exposure with hyperuricemia. |
| format | Article |
| id | doaj-art-36a42857a8a341358e2a8c0c0a2c9e92 |
| institution | DOAJ |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-36a42857a8a341358e2a8c0c0a2c9e922025-08-20T02:52:27ZengElsevierEcotoxicology and Environmental Safety0147-65132025-03-0129211794310.1016/j.ecoenv.2025.117943Association between urinary metal concentrations and hyperuricemia in Chinese community-dwelling elderly: Exploring the mediating role of estimating glomerular filtration rateZeyang Bai0Yuqing Dai1Siyu Duan2Zhongyuan Zhang3Zhuoheng Shen4Meiyan Li5Limeng Xiong6Jinhao Jia7Yi Zhao8Yihong Di9Huifang Yang10Jian Sun11Rui Zhang12Department of Medical Records and Statistics, General Hospital of Ningxia Medical University, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 750004, PR China; Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, Ningxia 750004, PR ChinaDepartment of Medical Records and Statistics, General Hospital of Ningxia Medical University, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 750004, PR China; Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, Ningxia 750004, PR ChinaDepartment of Medical Records and Statistics, General Hospital of Ningxia Medical University, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 750004, PR China; Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, Ningxia 750004, PR ChinaDepartment of Medical Records and Statistics, General Hospital of Ningxia Medical University, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 750004, PR China; Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, Ningxia 750004, PR ChinaDepartment of Medical Records and Statistics, General Hospital of Ningxia Medical University, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 750004, PR China; Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, Ningxia 750004, PR ChinaDepartment of Medical Records and Statistics, General Hospital of Ningxia Medical University, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 750004, PR China; Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, Ningxia 750004, PR ChinaDepartment of Medical Records and Statistics, General Hospital of Ningxia Medical University, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 750004, PR China; Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, Ningxia 750004, PR ChinaDepartment of Medical Records and Statistics, General Hospital of Ningxia Medical University, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 750004, PR China; Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, Ningxia 750004, PR ChinaDepartment of Medical Records and Statistics, General Hospital of Ningxia Medical University, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 750004, PR China; NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan, Ningxia 750004, PR China; Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, Ningxia 750004, PR ChinaDepartment of Medical Records and Statistics, General Hospital of Ningxia Medical University, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 750004, PR China; Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, Ningxia 750004, PR China; Correspondence to: No.1160, No.804, Shengli Street, Xingqing District, Yinchuan 750004, PR China.Department of Medical Records and Statistics, General Hospital of Ningxia Medical University, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 750004, PR China; Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, Ningxia 750004, PR China; Correspondence to: No.1160, No.804, Shengli Street, Xingqing District, Yinchuan 750004, PR China.Department of Medical Records and Statistics, General Hospital of Ningxia Medical University, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 750004, PR China; Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, Ningxia 750004, PR China; Correspondence to: No.1160, No.804, Shengli Street, Xingqing District, Yinchuan 750004, PR China.Department of Medical Records and Statistics, General Hospital of Ningxia Medical University, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 750004, PR China; Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, Ningxia 750004, PR China; Correspondence to: No.1160, No.804, Shengli Street, Xingqing District, Yinchuan 750004, PR China.Background: It has been shown that multiple metals exposure is associated with hyperuricemia. However, previous studies on the association and interaction between multiple metals exposure and hyperuricemia have been controversial, and there has been little evaluation of the potential mediating role of estimating glomerular filtration rate (eGFR). Methods: In this study, levels of 12 metals in the urine of 3756 study participants were measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). The associations between urinary metals and the hyperuricemia were analyzed by multivariable logistic regression model and restricted cubic spline (RCS). Weighted Quantile Sum (WQS) regression was used to explore the weight of each metal. Bayesian Kernel Machine Regression (BKMR) was used to explore the join effect of mixed metal exposure. Mediation analysis was used to explore the role of eGFR in relationship between urinary metal concentration and hyperuricemia. Results: In the multi-metal model, the multivariate-adjusted odds ratio (OR) and 95 % confidence interval (CI) of hyperuricemia were 0.89 (0.81,0.99) for Fe, 0.79 (0.70,0.89) for Se, 0.84 (0.75,0.93) for Cd, 0.87 (0.79,0.96) for Pb, 1.36 (1.23,1.51) for Zn (all P < 0.05). The RCS regression indicated signification nonlinear associations for Zn and Pb (all P-non-linear <0.05). The WQS regression model based on the negative fit showed that the maximum weight of Cd is 43.1 %. In the BKMR model, metal mixtures showed an overall negative association with the risk of developing hyperuricemia, and we also found interactions between Zn and Pb. Mediation analysis showed that eGFR mediated the association between Fe, Se, Cd, Pb and hyperuricemia with mediation ratios of 11.18 %, 12.10 %, 9.60 %, and 12.01 %, respectively. Conclusions: The metal mixture in urine is negatively correlated with hyperuricemia, with Cd having the greatest impact. eGFR may play a partial role in association of Fe, Se, Cd and Pb exposure with hyperuricemia.http://www.sciencedirect.com/science/article/pii/S0147651325002799HyperuricemiaUrinary metalsEstimating glomerular filtration rateCommunity-dwelling elderlyMediation |
| spellingShingle | Zeyang Bai Yuqing Dai Siyu Duan Zhongyuan Zhang Zhuoheng Shen Meiyan Li Limeng Xiong Jinhao Jia Yi Zhao Yihong Di Huifang Yang Jian Sun Rui Zhang Association between urinary metal concentrations and hyperuricemia in Chinese community-dwelling elderly: Exploring the mediating role of estimating glomerular filtration rate Ecotoxicology and Environmental Safety Hyperuricemia Urinary metals Estimating glomerular filtration rate Community-dwelling elderly Mediation |
| title | Association between urinary metal concentrations and hyperuricemia in Chinese community-dwelling elderly: Exploring the mediating role of estimating glomerular filtration rate |
| title_full | Association between urinary metal concentrations and hyperuricemia in Chinese community-dwelling elderly: Exploring the mediating role of estimating glomerular filtration rate |
| title_fullStr | Association between urinary metal concentrations and hyperuricemia in Chinese community-dwelling elderly: Exploring the mediating role of estimating glomerular filtration rate |
| title_full_unstemmed | Association between urinary metal concentrations and hyperuricemia in Chinese community-dwelling elderly: Exploring the mediating role of estimating glomerular filtration rate |
| title_short | Association between urinary metal concentrations and hyperuricemia in Chinese community-dwelling elderly: Exploring the mediating role of estimating glomerular filtration rate |
| title_sort | association between urinary metal concentrations and hyperuricemia in chinese community dwelling elderly exploring the mediating role of estimating glomerular filtration rate |
| topic | Hyperuricemia Urinary metals Estimating glomerular filtration rate Community-dwelling elderly Mediation |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325002799 |
| work_keys_str_mv | AT zeyangbai associationbetweenurinarymetalconcentrationsandhyperuricemiainchinesecommunitydwellingelderlyexploringthemediatingroleofestimatingglomerularfiltrationrate AT yuqingdai associationbetweenurinarymetalconcentrationsandhyperuricemiainchinesecommunitydwellingelderlyexploringthemediatingroleofestimatingglomerularfiltrationrate AT siyuduan associationbetweenurinarymetalconcentrationsandhyperuricemiainchinesecommunitydwellingelderlyexploringthemediatingroleofestimatingglomerularfiltrationrate AT zhongyuanzhang associationbetweenurinarymetalconcentrationsandhyperuricemiainchinesecommunitydwellingelderlyexploringthemediatingroleofestimatingglomerularfiltrationrate AT zhuohengshen associationbetweenurinarymetalconcentrationsandhyperuricemiainchinesecommunitydwellingelderlyexploringthemediatingroleofestimatingglomerularfiltrationrate AT meiyanli associationbetweenurinarymetalconcentrationsandhyperuricemiainchinesecommunitydwellingelderlyexploringthemediatingroleofestimatingglomerularfiltrationrate AT limengxiong associationbetweenurinarymetalconcentrationsandhyperuricemiainchinesecommunitydwellingelderlyexploringthemediatingroleofestimatingglomerularfiltrationrate AT jinhaojia associationbetweenurinarymetalconcentrationsandhyperuricemiainchinesecommunitydwellingelderlyexploringthemediatingroleofestimatingglomerularfiltrationrate AT yizhao associationbetweenurinarymetalconcentrationsandhyperuricemiainchinesecommunitydwellingelderlyexploringthemediatingroleofestimatingglomerularfiltrationrate AT yihongdi associationbetweenurinarymetalconcentrationsandhyperuricemiainchinesecommunitydwellingelderlyexploringthemediatingroleofestimatingglomerularfiltrationrate AT huifangyang associationbetweenurinarymetalconcentrationsandhyperuricemiainchinesecommunitydwellingelderlyexploringthemediatingroleofestimatingglomerularfiltrationrate AT jiansun associationbetweenurinarymetalconcentrationsandhyperuricemiainchinesecommunitydwellingelderlyexploringthemediatingroleofestimatingglomerularfiltrationrate AT ruizhang associationbetweenurinarymetalconcentrationsandhyperuricemiainchinesecommunitydwellingelderlyexploringthemediatingroleofestimatingglomerularfiltrationrate |