Network analysis of the cerebrospinal fluid proteome reveals shared and unique differences between sporadic and familial forms of amyotrophic lateral sclerosis

Network analysis of the cerebrospinal fluid proteome reveals shared and unique differences between sporadic and familial forms of amyotrophic lateral sclerosis

Abstract Background Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease involving loss of motor neurons, typically results in death within 3–5 years of disease onset. Although roughly 10% of cases can be linked to a specific inherited mutation (e.g., C9orf72 hexanucleotide repeat expans...

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Main Authors: Adam N. Trautwig, Edward J. Fox, Eric B. Dammer, Anantharaman Shantaraman, Lingyan Ping, Duc M. Duong, Caroline M. Watson, Fang Wu, Seneshaw Asress, Qi Guo, Allan I. Levey, James J. Lah, Federico Verde, Alberto Doretti, Antonia Ratti, Nicola Ticozzi, Cindy V. Ly, Timothy M. Miller, Mark A. Garret, James D. Berry, Eleanor V. Thomas, Christina N. Fournier, Zachary T. McEachin, Nicholas T. Seyfried, Jonathan D. Glass
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Neurodegeneration
Subjects:
Amyotrophic Lateral Sclerosis ALS
C9orf72
SOD1
Cerebrospinal Fluid (CSF)
Weighted Gene Co-Expression Network Analysis (WGCNA)
Differentially Abundant Proteins (DAP)
Online Access:https://doi.org/10.1186/s13024-025-00838-9
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