Advancing the role of real-world evidence in comparative effectiveness research
Aim: Comparative effectiveness research (CER) is essential for making informed decisions about drug access. It provides insights into the effectiveness and safety of new drugs compared with existing treatments, thereby guiding better healthcare decisions and ensuring that new therapies meet the re...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Becaris Publishing Limited
2024-10-01
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| Series: | Journal of Comparative Effectiveness Research |
| Subjects: | |
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| Summary: | Aim: Comparative effectiveness research (CER) is essential for making informed decisions about drug
access. It provides insights into the effectiveness and safety of new drugs compared with existing
treatments, thereby guiding better healthcare decisions and ensuring that new therapies meet the realworld
needs of patients and healthcare systems. Objective: To provide a tool that assists analysts and
decision-makers in identifying the most suitable analytical approach for answering a CER question, given
specific data availability contexts. Methods: A systematic literature review of the scientific literature was
performed and existing regulatory and health technology assessment (HTA) guidance were evaluated to
identify and compare recommendations and best practices. Based on this review a methods flowchart
that synthesizes current practices and requirements was proposed. Results: The review did not find any
papers that clearly identified the most appropriate analytical approach for answering CER questions under
various conditions. Therefore, a methods flowchart was designed to inform analyst and decision makers
choices starting from a well-defined scientific question. Conclusion: The proposed methods flowchart
offers clear guidance on CER methodologies across a range of settings and research needs. It begins with
a well-defined research question and considers multiple feasibility aspects related to CER. This tool aims to
standardize methods, ensure rigorous and consistent research quality and promote a culture of evidencebased
decision-making in healthcare. |
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| ISSN: | 2042-6313 |