Genotype and transcript processing of the tumour necrosis factor receptor TNFRSF1A in epithelial cells: implications for survival in cystic fibrosisResearch in context

Genotype and transcript processing of the tumour necrosis factor receptor TNFRSF1A in epithelial cells: implications for survival in cystic fibrosisResearch in context

Summary: Background: Cystic fibrosis is caused by mutations of the cystic fibrosis transmembrane conductance regulator, CFTR, an epithelial anion transport protein, responsible for, inter alia, sputum viscoelasticity in the lung. We previously identified the TNF receptor superfamily 1A TNFRSF1A (TN...

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Main Authors: Alexander Uden, Inga Dunsche, Sabina Janciauskiene, Simon Gräber, Longhua Feng, Stephanie Tamm, Silke Hedtfeld, Gesa Stege, Kirsten Jahn, Julia Kontsendorn, Nadine Alfeis, Iris Kühbandner, Rebecca Minso, Christian Dopfer, Matthias Griese, Olaf Sommerburg, Felix C. Ringshausen, Lutz Nährlich, Gesine Hansen, Tobias Welte, Peter Braubach, Marcus A. Mall, Burkhard Tümmler, Anna-Maria Dittrich, Frauke Stanke, Josje Altenburg, Els Aertgeerts, Vera Bauer, Johanna M.W. van den Berg, Sebastian F.N. Bode, Carlo Castellani, Raphael Chiron, Owen Dempsey, Angelika Dübbers, Johannes Eder, Helmut Ellemunter, Mary Herzig, Andrea Lakatos-Krepcik, Ulrika Lindberg, Jan ter Maaten, Henry Mazurek, Paola Melotti, Rita Francesca Padoan, Caroline Raynal, Sabina Seehofer, Nicholas J. Simmonds, Christina Smaczny, Prasima Srivastava, Nathalie Stremler, Fiona Thomson, Maria Dolores Pastor Vivero, Paul Vöhringer, Nadine Wollscheid, Domenique D. Zomer-van Ommen
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:EBioMedicine
Subjects:
Cystic fibrosis
Patient survival
Genetic association study
Tumour necrosis factor receptor
TNFRSF1A
Alternative transcript
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425002920
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