Assessment of retinal and choroidal microcirculatory alterations following radiofrequency catheter ablation in atrial fibrillation patients using swept-source optical coherence tomography angiography
PurposeThis study employed swept-source optical coherence tomography angiography (SS-OCTA) to explore potential hemodynamic alterations in the retina and choroid following radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF).MethodsA total of 58 eyes from 32 patients were included, w...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1612303/full |
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| author | Jin Wang Huiran Yang Qingjian Li Yucen Wang Pei Zhang Pei Zhang Zhiliang Wang |
| author_facet | Jin Wang Huiran Yang Qingjian Li Yucen Wang Pei Zhang Pei Zhang Zhiliang Wang |
| author_sort | Jin Wang |
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| description | PurposeThis study employed swept-source optical coherence tomography angiography (SS-OCTA) to explore potential hemodynamic alterations in the retina and choroid following radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF).MethodsA total of 58 eyes from 32 patients were included, with SS-OCTA examinations conducted preoperatively and 1 day postoperatively. The evaluated parameters encompassed vessel density (VD) of the superficial vascular complex (SVC), VD of the deep vascular complex (DVC), choroidal vascular index (CVI), choroidal thickness (CT), thickness of the superficial retinal layer (SRL), and thickness of the deeper retinal layer (DRL).ResultsResults indicated no significant changes in the VD of the SVC and DVC, nor in the thickness of the superficial and deeper retinal layers. Conversely, CT demonstrated a significant increase (P < 0.05) and the CVI exhibited a notable rise exclusively within the 1-mm diameter region centered on the fovea (P < 0.05).ConclusionThese findings underscore the remarkable hemodynamic stability of retinal microcirculation in the early postoperative phase. The observed increase in CT and localized elevation in CVI may signify compensatory mechanisms involving enhanced postoperative choroidal perfusion and redistribution of cardiac output, thereby reinforcing the choroid’s superior sensitivity as a biomarker for detecting subtle hemodynamic shifts in AF-related ocular pathology. |
| format | Article |
| id | doaj-art-368f749fe1c8450dab9ffe39a6b03a7d |
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| issn | 2296-634X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-368f749fe1c8450dab9ffe39a6b03a7d2025-08-20T02:35:46ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-06-011310.3389/fcell.2025.16123031612303Assessment of retinal and choroidal microcirculatory alterations following radiofrequency catheter ablation in atrial fibrillation patients using swept-source optical coherence tomography angiographyJin Wang0Huiran Yang1Qingjian Li2Yucen Wang3Pei Zhang4Pei Zhang5Zhiliang Wang6Department of Cardiology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Shanghai Fourth Rehabilitation Hospital, Shanghai, ChinaDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, ChinaPurposeThis study employed swept-source optical coherence tomography angiography (SS-OCTA) to explore potential hemodynamic alterations in the retina and choroid following radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF).MethodsA total of 58 eyes from 32 patients were included, with SS-OCTA examinations conducted preoperatively and 1 day postoperatively. The evaluated parameters encompassed vessel density (VD) of the superficial vascular complex (SVC), VD of the deep vascular complex (DVC), choroidal vascular index (CVI), choroidal thickness (CT), thickness of the superficial retinal layer (SRL), and thickness of the deeper retinal layer (DRL).ResultsResults indicated no significant changes in the VD of the SVC and DVC, nor in the thickness of the superficial and deeper retinal layers. Conversely, CT demonstrated a significant increase (P < 0.05) and the CVI exhibited a notable rise exclusively within the 1-mm diameter region centered on the fovea (P < 0.05).ConclusionThese findings underscore the remarkable hemodynamic stability of retinal microcirculation in the early postoperative phase. The observed increase in CT and localized elevation in CVI may signify compensatory mechanisms involving enhanced postoperative choroidal perfusion and redistribution of cardiac output, thereby reinforcing the choroid’s superior sensitivity as a biomarker for detecting subtle hemodynamic shifts in AF-related ocular pathology.https://www.frontiersin.org/articles/10.3389/fcell.2025.1612303/fullatrial fibrillationoptical coherence tomography angiographyvessel densitychoroidal vascular indexchoroidal thickness |
| spellingShingle | Jin Wang Huiran Yang Qingjian Li Yucen Wang Pei Zhang Pei Zhang Zhiliang Wang Assessment of retinal and choroidal microcirculatory alterations following radiofrequency catheter ablation in atrial fibrillation patients using swept-source optical coherence tomography angiography Frontiers in Cell and Developmental Biology atrial fibrillation optical coherence tomography angiography vessel density choroidal vascular index choroidal thickness |
| title | Assessment of retinal and choroidal microcirculatory alterations following radiofrequency catheter ablation in atrial fibrillation patients using swept-source optical coherence tomography angiography |
| title_full | Assessment of retinal and choroidal microcirculatory alterations following radiofrequency catheter ablation in atrial fibrillation patients using swept-source optical coherence tomography angiography |
| title_fullStr | Assessment of retinal and choroidal microcirculatory alterations following radiofrequency catheter ablation in atrial fibrillation patients using swept-source optical coherence tomography angiography |
| title_full_unstemmed | Assessment of retinal and choroidal microcirculatory alterations following radiofrequency catheter ablation in atrial fibrillation patients using swept-source optical coherence tomography angiography |
| title_short | Assessment of retinal and choroidal microcirculatory alterations following radiofrequency catheter ablation in atrial fibrillation patients using swept-source optical coherence tomography angiography |
| title_sort | assessment of retinal and choroidal microcirculatory alterations following radiofrequency catheter ablation in atrial fibrillation patients using swept source optical coherence tomography angiography |
| topic | atrial fibrillation optical coherence tomography angiography vessel density choroidal vascular index choroidal thickness |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1612303/full |
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