Long-Term Outcomes of Pediatric Cerebral Arteriovenous Malformations: A Ten-Year Single-Center Retrospective Study
<i>Background and Objectives</i>: Pediatric cerebral arteriovenous malformations (AVMs) are associated with significant morbidity and mortality. The aim of this study was to assess the long-term outcomes of surgical excision and stereotactic radiosurgery (SRS) of cerebral AVMs in pediatr...
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2025-06-01
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| author | Mei-Cheng Hsiao Yuang-Seng Tsuei Hung-Chuan Pan Ming-Hsi Sun Wen-Hsien Chen Hung-Chieh Chen Chiung-Chyi Shen Chi-Ruei Li Yu-Cheng Chou |
| author_facet | Mei-Cheng Hsiao Yuang-Seng Tsuei Hung-Chuan Pan Ming-Hsi Sun Wen-Hsien Chen Hung-Chieh Chen Chiung-Chyi Shen Chi-Ruei Li Yu-Cheng Chou |
| author_sort | Mei-Cheng Hsiao |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Pediatric cerebral arteriovenous malformations (AVMs) are associated with significant morbidity and mortality. The aim of this study was to assess the long-term outcomes of surgical excision and stereotactic radiosurgery (SRS) of cerebral AVMs in pediatric patients. <i>Materials and Methods</i>: A single-center retrospective analysis was conducted using data obtained from a single medical center between January 2012 and July 2022. The Modified Rankin Scale (mRS) at admission and discharge and the Spetzler–Martin (SM) scores were analyzed. <i>Results</i>: Among 45 patients (mean age 11.8 years), 19 patients (42.2%) received surgical resection, with good outcomes (mRS 0–2) in 16 patients and complete obliteration in all patients. In total, 26 patients (57.8%) were managed with SRS. After 36.3 months on average, complete obliteration in 19 of 26 patients (69.2%) was confirmed. Among the 7 SRS patients without complete obliteration, 6 had residual cerebral AVMs at the last follow-up, and 1 had recurrence. All patients receiving SRS had favorable outcomes (mRS 0–1) and no apparent radiosurgery-related complications. <i>Conclusions</i>: In our study, the surgical resection or SRS was selected based on individual patient conditions, and the overall outcomes were satisfactory. Both surgical resection and SRS proved to be effective treatment options. Microsurgical resection demonstrated a high rate of obliteration and remains a favorable therapeutic choice with acceptable risks for pediatric AVMs. |
| format | Article |
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| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj-art-368da59c2c744d4cbb02694bd9e31ef32025-08-20T03:08:09ZengMDPI AGMedicina1010-660X1648-91442025-06-01617117710.3390/medicina61071177Long-Term Outcomes of Pediatric Cerebral Arteriovenous Malformations: A Ten-Year Single-Center Retrospective StudyMei-Cheng Hsiao0Yuang-Seng Tsuei1Hung-Chuan Pan2Ming-Hsi Sun3Wen-Hsien Chen4Hung-Chieh Chen5Chiung-Chyi Shen6Chi-Ruei Li7Yu-Cheng Chou8Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung 407, TaiwanDepartment of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung 407, TaiwanDepartment of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung 407, TaiwanDepartment of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung 407, TaiwanDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, TaiwanDepartment of Radiology, Taichung Veterans General Hospital, Taichung 407, TaiwanDepartment of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung 407, TaiwanDepartment of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung 407, TaiwanDepartment of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung 407, Taiwan<i>Background and Objectives</i>: Pediatric cerebral arteriovenous malformations (AVMs) are associated with significant morbidity and mortality. The aim of this study was to assess the long-term outcomes of surgical excision and stereotactic radiosurgery (SRS) of cerebral AVMs in pediatric patients. <i>Materials and Methods</i>: A single-center retrospective analysis was conducted using data obtained from a single medical center between January 2012 and July 2022. The Modified Rankin Scale (mRS) at admission and discharge and the Spetzler–Martin (SM) scores were analyzed. <i>Results</i>: Among 45 patients (mean age 11.8 years), 19 patients (42.2%) received surgical resection, with good outcomes (mRS 0–2) in 16 patients and complete obliteration in all patients. In total, 26 patients (57.8%) were managed with SRS. After 36.3 months on average, complete obliteration in 19 of 26 patients (69.2%) was confirmed. Among the 7 SRS patients without complete obliteration, 6 had residual cerebral AVMs at the last follow-up, and 1 had recurrence. All patients receiving SRS had favorable outcomes (mRS 0–1) and no apparent radiosurgery-related complications. <i>Conclusions</i>: In our study, the surgical resection or SRS was selected based on individual patient conditions, and the overall outcomes were satisfactory. Both surgical resection and SRS proved to be effective treatment options. Microsurgical resection demonstrated a high rate of obliteration and remains a favorable therapeutic choice with acceptable risks for pediatric AVMs.https://www.mdpi.com/1648-9144/61/7/1177pediatriccerebralarteriovenous malformationssurgical resectionstereotactic radiosurgeryhydrocephalus |
| spellingShingle | Mei-Cheng Hsiao Yuang-Seng Tsuei Hung-Chuan Pan Ming-Hsi Sun Wen-Hsien Chen Hung-Chieh Chen Chiung-Chyi Shen Chi-Ruei Li Yu-Cheng Chou Long-Term Outcomes of Pediatric Cerebral Arteriovenous Malformations: A Ten-Year Single-Center Retrospective Study Medicina pediatric cerebral arteriovenous malformations surgical resection stereotactic radiosurgery hydrocephalus |
| title | Long-Term Outcomes of Pediatric Cerebral Arteriovenous Malformations: A Ten-Year Single-Center Retrospective Study |
| title_full | Long-Term Outcomes of Pediatric Cerebral Arteriovenous Malformations: A Ten-Year Single-Center Retrospective Study |
| title_fullStr | Long-Term Outcomes of Pediatric Cerebral Arteriovenous Malformations: A Ten-Year Single-Center Retrospective Study |
| title_full_unstemmed | Long-Term Outcomes of Pediatric Cerebral Arteriovenous Malformations: A Ten-Year Single-Center Retrospective Study |
| title_short | Long-Term Outcomes of Pediatric Cerebral Arteriovenous Malformations: A Ten-Year Single-Center Retrospective Study |
| title_sort | long term outcomes of pediatric cerebral arteriovenous malformations a ten year single center retrospective study |
| topic | pediatric cerebral arteriovenous malformations surgical resection stereotactic radiosurgery hydrocephalus |
| url | https://www.mdpi.com/1648-9144/61/7/1177 |
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