Effects of trimester-specific urinary aluminum concentrations on ultrasound measures of fetal growth and size at birth: A longitudinal cohort study in Chinese women
Objective: Aluminum (Al) has been proposed as a potential factor influencing fetal growth. However, the existing study findings are inconsistent and there is a lack of population-based epidemiological studies. Our study aimed to evaluate the trimester-specific correlations of Al exposure with fetal...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324015859 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823856892113321984 |
|---|---|
| author | Haiying Chen Wenjing Yan Xueyan Wu Yuanyuan Li |
| author_facet | Haiying Chen Wenjing Yan Xueyan Wu Yuanyuan Li |
| author_sort | Haiying Chen |
| collection | DOAJ |
| description | Objective: Aluminum (Al) has been proposed as a potential factor influencing fetal growth. However, the existing study findings are inconsistent and there is a lack of population-based epidemiological studies. Our study aimed to evaluate the trimester-specific correlations of Al exposure with fetal development characteristics. Methods: Between 2013 and 2016, 3599 women from Wuhan, China were enrolled in the prospective cohort study. The concentrations of Al were quantified in urine samples obtained from pregnant women during the 1st, 2nd and 3rd trimesters by inductively coupled plasma mass spectrometry. The study used linear regressions with generalized estimating equation to determine the connections between specific gravity-adjusted urinary Al concentrations in each trimester and fetal growth parameters and birth size indicators. Results: Trimester-specific Al exposure throughout pregnancy was found to have a negative impact on fetal growth and birth parameters. Besides, statistically significant interactions were detected between biparietal diameter (BPD) (Pinteraction = 0.007), head circumference (Pinteraction = 0.026) at 16 weeks’ gestation in the first trimester, BPD (Pinteraction = 0.015) at 24 weeks’ gestation in the second trimester, BPD (Pinteraction = 0.014) at 31 weeks’ gestation in the second trimester and BPD (Pinteraction = 0.035) at 37 weeks’ gestation in the third trimester and fetal sex, and the strength of the association between the level of Al exposure and BPD was significantly stronger in female fetuses than in male fetuses. Furthermore, we observed three distinct trajectories of trimester-specific Al concentrations during pregnancy. Compared to participants with low-stable group of Al concentrations trajectory, high-stable group was associated with more decrease level of fetal growth parameters and birth size indicators. Conclusion: Our study results reveal that Al might have harmful effects on fetal growth and birth size indicators, especially in female fetuses. Further study is required to examine our findings in other populations. |
| format | Article |
| id | doaj-art-368b2c07892d45eca89c74b5fd9593a5 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-368b2c07892d45eca89c74b5fd9593a52025-02-12T05:29:24ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117509Effects of trimester-specific urinary aluminum concentrations on ultrasound measures of fetal growth and size at birth: A longitudinal cohort study in Chinese womenHaiying Chen0Wenjing Yan1Xueyan Wu2Yuanyuan Li3Department of Ultrasound, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR ChinaDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR ChinaDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China; Correspondence to: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, PR China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Correspondence to: Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.Objective: Aluminum (Al) has been proposed as a potential factor influencing fetal growth. However, the existing study findings are inconsistent and there is a lack of population-based epidemiological studies. Our study aimed to evaluate the trimester-specific correlations of Al exposure with fetal development characteristics. Methods: Between 2013 and 2016, 3599 women from Wuhan, China were enrolled in the prospective cohort study. The concentrations of Al were quantified in urine samples obtained from pregnant women during the 1st, 2nd and 3rd trimesters by inductively coupled plasma mass spectrometry. The study used linear regressions with generalized estimating equation to determine the connections between specific gravity-adjusted urinary Al concentrations in each trimester and fetal growth parameters and birth size indicators. Results: Trimester-specific Al exposure throughout pregnancy was found to have a negative impact on fetal growth and birth parameters. Besides, statistically significant interactions were detected between biparietal diameter (BPD) (Pinteraction = 0.007), head circumference (Pinteraction = 0.026) at 16 weeks’ gestation in the first trimester, BPD (Pinteraction = 0.015) at 24 weeks’ gestation in the second trimester, BPD (Pinteraction = 0.014) at 31 weeks’ gestation in the second trimester and BPD (Pinteraction = 0.035) at 37 weeks’ gestation in the third trimester and fetal sex, and the strength of the association between the level of Al exposure and BPD was significantly stronger in female fetuses than in male fetuses. Furthermore, we observed three distinct trajectories of trimester-specific Al concentrations during pregnancy. Compared to participants with low-stable group of Al concentrations trajectory, high-stable group was associated with more decrease level of fetal growth parameters and birth size indicators. Conclusion: Our study results reveal that Al might have harmful effects on fetal growth and birth size indicators, especially in female fetuses. Further study is required to examine our findings in other populations.http://www.sciencedirect.com/science/article/pii/S0147651324015859AluminumBirth cohort studyFetal growthBirth sizePregnancyRepeated measure |
| spellingShingle | Haiying Chen Wenjing Yan Xueyan Wu Yuanyuan Li Effects of trimester-specific urinary aluminum concentrations on ultrasound measures of fetal growth and size at birth: A longitudinal cohort study in Chinese women Ecotoxicology and Environmental Safety Aluminum Birth cohort study Fetal growth Birth size Pregnancy Repeated measure |
| title | Effects of trimester-specific urinary aluminum concentrations on ultrasound measures of fetal growth and size at birth: A longitudinal cohort study in Chinese women |
| title_full | Effects of trimester-specific urinary aluminum concentrations on ultrasound measures of fetal growth and size at birth: A longitudinal cohort study in Chinese women |
| title_fullStr | Effects of trimester-specific urinary aluminum concentrations on ultrasound measures of fetal growth and size at birth: A longitudinal cohort study in Chinese women |
| title_full_unstemmed | Effects of trimester-specific urinary aluminum concentrations on ultrasound measures of fetal growth and size at birth: A longitudinal cohort study in Chinese women |
| title_short | Effects of trimester-specific urinary aluminum concentrations on ultrasound measures of fetal growth and size at birth: A longitudinal cohort study in Chinese women |
| title_sort | effects of trimester specific urinary aluminum concentrations on ultrasound measures of fetal growth and size at birth a longitudinal cohort study in chinese women |
| topic | Aluminum Birth cohort study Fetal growth Birth size Pregnancy Repeated measure |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324015859 |
| work_keys_str_mv | AT haiyingchen effectsoftrimesterspecificurinaryaluminumconcentrationsonultrasoundmeasuresoffetalgrowthandsizeatbirthalongitudinalcohortstudyinchinesewomen AT wenjingyan effectsoftrimesterspecificurinaryaluminumconcentrationsonultrasoundmeasuresoffetalgrowthandsizeatbirthalongitudinalcohortstudyinchinesewomen AT xueyanwu effectsoftrimesterspecificurinaryaluminumconcentrationsonultrasoundmeasuresoffetalgrowthandsizeatbirthalongitudinalcohortstudyinchinesewomen AT yuanyuanli effectsoftrimesterspecificurinaryaluminumconcentrationsonultrasoundmeasuresoffetalgrowthandsizeatbirthalongitudinalcohortstudyinchinesewomen |