Sepsis therapies: learning from 30 years of failure of translational research to propose new leads
Abstract Sepsis has been identified by the World Health Organization (WHO) as a global health priority. There has been a tremendous effort to decipher underlying mechanisms responsible for organ failure and death, and to develop new treatments. Despite saving thousands of animals over the last three...
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| Format: | Article |
| Language: | English |
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Springer Nature
2020-03-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.201810128 |
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| _version_ | 1849226052283400192 |
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| author | Jean‐Marc Cavaillon Mervyn Singer Tomasz Skirecki |
| author_facet | Jean‐Marc Cavaillon Mervyn Singer Tomasz Skirecki |
| author_sort | Jean‐Marc Cavaillon |
| collection | DOAJ |
| description | Abstract Sepsis has been identified by the World Health Organization (WHO) as a global health priority. There has been a tremendous effort to decipher underlying mechanisms responsible for organ failure and death, and to develop new treatments. Despite saving thousands of animals over the last three decades in multiple preclinical studies, no new effective drug has emerged that has clearly improved patient outcomes. In the present review, we analyze the reasons for this failure, focusing on the inclusion of inappropriate patients and the use of irrelevant animal models. We advocate against repeating the same mistakes and propose changes to the research paradigm. We discuss the long‐term consequences of surviving sepsis and, finally, list some putative approaches—both old and new—that could help save lives and improve survivorship. |
| format | Article |
| id | doaj-art-36873f3afed940c48cc03d7a751ab5d3 |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-36873f3afed940c48cc03d7a751ab5d32025-08-24T11:44:14ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842020-03-0112412410.15252/emmm.201810128Sepsis therapies: learning from 30 years of failure of translational research to propose new leadsJean‐Marc Cavaillon0Mervyn Singer1Tomasz Skirecki2Experimental Neuropathology Unit, Institut PasteurBloomsbury Institute of Intensive Care Medicine, University College LondonLaboratory of Flow Cytometry and Department of Anesthesiology and Intensive Care Medicine, Centre of Postgraduate Medical EducationAbstract Sepsis has been identified by the World Health Organization (WHO) as a global health priority. There has been a tremendous effort to decipher underlying mechanisms responsible for organ failure and death, and to develop new treatments. Despite saving thousands of animals over the last three decades in multiple preclinical studies, no new effective drug has emerged that has clearly improved patient outcomes. In the present review, we analyze the reasons for this failure, focusing on the inclusion of inappropriate patients and the use of irrelevant animal models. We advocate against repeating the same mistakes and propose changes to the research paradigm. We discuss the long‐term consequences of surviving sepsis and, finally, list some putative approaches—both old and new—that could help save lives and improve survivorship.https://doi.org/10.15252/emmm.201810128animal modelscytokine stormpersonalized medicinereprogrammingsepsis |
| spellingShingle | Jean‐Marc Cavaillon Mervyn Singer Tomasz Skirecki Sepsis therapies: learning from 30 years of failure of translational research to propose new leads EMBO Molecular Medicine animal models cytokine storm personalized medicine reprogramming sepsis |
| title | Sepsis therapies: learning from 30 years of failure of translational research to propose new leads |
| title_full | Sepsis therapies: learning from 30 years of failure of translational research to propose new leads |
| title_fullStr | Sepsis therapies: learning from 30 years of failure of translational research to propose new leads |
| title_full_unstemmed | Sepsis therapies: learning from 30 years of failure of translational research to propose new leads |
| title_short | Sepsis therapies: learning from 30 years of failure of translational research to propose new leads |
| title_sort | sepsis therapies learning from 30 years of failure of translational research to propose new leads |
| topic | animal models cytokine storm personalized medicine reprogramming sepsis |
| url | https://doi.org/10.15252/emmm.201810128 |
| work_keys_str_mv | AT jeanmarccavaillon sepsistherapieslearningfrom30yearsoffailureoftranslationalresearchtoproposenewleads AT mervynsinger sepsistherapieslearningfrom30yearsoffailureoftranslationalresearchtoproposenewleads AT tomaszskirecki sepsistherapieslearningfrom30yearsoffailureoftranslationalresearchtoproposenewleads |