A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and Differentiation
Stem cell has immense potential in regenerative cellular therapy. Mesenchymal stem cells (MSCs) can become a potential attractive candidate for therapy due to its remarkable ability of self-renewal and differentiation into three lineages, i.e., ectoderm, mesoderm, and endoderm. Stem cell holds treme...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/7513404 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849306544712187904 |
|---|---|
| author | Bhuvan Saud Rajani Malla Kanti Shrestha |
| author_facet | Bhuvan Saud Rajani Malla Kanti Shrestha |
| author_sort | Bhuvan Saud |
| collection | DOAJ |
| description | Stem cell has immense potential in regenerative cellular therapy. Mesenchymal stem cells (MSCs) can become a potential attractive candidate for therapy due to its remarkable ability of self-renewal and differentiation into three lineages, i.e., ectoderm, mesoderm, and endoderm. Stem cell holds tremendous promises in the field of tissue regeneration and transplantation for disease treatments. Globally, medicinal plants are being used for the treatment and prevention of a variety of diseases. Phytochemicals like naringin, icariin, genistein, and resveratrol obtained from plants have been extensively used in traditional medicine for centuries. Certain bioactive compounds from plants increase the rate of tissue regeneration, differentiation, and immunomodulation. Several studies show that bioactive compounds from plants have a specific role (bioactive mediator) in regulating the rate of cell division and differentiation through complex signal pathways like BMP2, Runx2, and Wnt. The use of plant bioactive phytochemicals may also become promising in treating diseases like osteoporosis, neurodegenerative disorders, and other tissue degenerative disorders. Thus, the present review article is aimed at highlighting the roles and consequences of plant extracts on MSCs proliferation and desired lineage differentiations. |
| format | Article |
| id | doaj-art-36826f60cfcd45dfbb088e4a7c2189b2 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-36826f60cfcd45dfbb088e4a7c2189b22025-08-20T03:55:02ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/75134047513404A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and DifferentiationBhuvan Saud0Rajani Malla1Kanti Shrestha2Central Department of Biotechnology, Tribhuvan University, Kirtipur, NepalCentral Department of Biotechnology, Tribhuvan University, Kirtipur, NepalFaculty of Science, Nepal Academy of Science and Technology (NAST), Khumaltar, Lalitpur, NepalStem cell has immense potential in regenerative cellular therapy. Mesenchymal stem cells (MSCs) can become a potential attractive candidate for therapy due to its remarkable ability of self-renewal and differentiation into three lineages, i.e., ectoderm, mesoderm, and endoderm. Stem cell holds tremendous promises in the field of tissue regeneration and transplantation for disease treatments. Globally, medicinal plants are being used for the treatment and prevention of a variety of diseases. Phytochemicals like naringin, icariin, genistein, and resveratrol obtained from plants have been extensively used in traditional medicine for centuries. Certain bioactive compounds from plants increase the rate of tissue regeneration, differentiation, and immunomodulation. Several studies show that bioactive compounds from plants have a specific role (bioactive mediator) in regulating the rate of cell division and differentiation through complex signal pathways like BMP2, Runx2, and Wnt. The use of plant bioactive phytochemicals may also become promising in treating diseases like osteoporosis, neurodegenerative disorders, and other tissue degenerative disorders. Thus, the present review article is aimed at highlighting the roles and consequences of plant extracts on MSCs proliferation and desired lineage differentiations.http://dx.doi.org/10.1155/2019/7513404 |
| spellingShingle | Bhuvan Saud Rajani Malla Kanti Shrestha A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and Differentiation Stem Cells International |
| title | A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and Differentiation |
| title_full | A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and Differentiation |
| title_fullStr | A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and Differentiation |
| title_full_unstemmed | A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and Differentiation |
| title_short | A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and Differentiation |
| title_sort | review on the effect of plant extract on mesenchymal stem cell proliferation and differentiation |
| url | http://dx.doi.org/10.1155/2019/7513404 |
| work_keys_str_mv | AT bhuvansaud areviewontheeffectofplantextractonmesenchymalstemcellproliferationanddifferentiation AT rajanimalla areviewontheeffectofplantextractonmesenchymalstemcellproliferationanddifferentiation AT kantishrestha areviewontheeffectofplantextractonmesenchymalstemcellproliferationanddifferentiation AT bhuvansaud reviewontheeffectofplantextractonmesenchymalstemcellproliferationanddifferentiation AT rajanimalla reviewontheeffectofplantextractonmesenchymalstemcellproliferationanddifferentiation AT kantishrestha reviewontheeffectofplantextractonmesenchymalstemcellproliferationanddifferentiation |