Pharmaceutical development of sangviritrin spray for the treatment of inflammatory diseases of the oral cavity
Introduction. One of the most common bacterial infections includes acute and chronic tonsillitis, affecting 10 to 15 % of adults and approximately 20–25 % of children worldwide, according to the World Health Organization. The focus of this study was an original substance, sangviritrin, containing no...
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2025-03-01
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| Series: | Разработка и регистрация лекарственных средств |
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| Online Access: | https://www.pharmjournal.ru/jour/article/view/2013 |
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| author | M. N. Anurova Ya. A. Dorokhina A. S. Gulenkov N. B. Demina L. A. Korol P. G. Mizina |
| author_facet | M. N. Anurova Ya. A. Dorokhina A. S. Gulenkov N. B. Demina L. A. Korol P. G. Mizina |
| author_sort | M. N. Anurova |
| collection | DOAJ |
| description | Introduction. One of the most common bacterial infections includes acute and chronic tonsillitis, affecting 10 to 15 % of adults and approximately 20–25 % of children worldwide, according to the World Health Organization. The focus of this study was an original substance, sangviritrin, containing no less than 96.5 % of the sum of bisulfates of two alkaloids: sanguinarine and chelerythrine. Given the high antimicrobial activity of sangviritrin, the research aimed to develop a local delivery system based on this medicinal substance.Aim. The aim of this work was to develop an oral medicinal form of sangviritrin.Materials and Methods. Sangviritrin, produced by the All-Russian Scientific Research Institute of Medicinal and Aromatic Plants, was used as the active pharmaceutical ingredient. The selection of auxiliary components was carried out in accordance with the methodologies specified in the State Pharmacopoeia XV edition. The organoleptic properties of the substance and spray samples were studied using A. I. Tenzova's method. The local irritant action of the spray was assessed using the conjunctival test method on chinchilla rabbits weighing 3.5–4.3 kg. Quantitative determination of sangviritrin in the medicinal form was performed using spectrophotometric methods at a wavelength of 321 ± 2 nm on a spectrophotometer SPECORD® 200 PLUS (Analytik Jena GmbH+Co. KG, Germany).Results and Discussion. Optimal auxiliary component compositions were selected based on measurements of spray technological parameters. A comprehensive approach was justified for correcting the organoleptic properties of the substance, involving the introduction of a minimal amount of sweeteners and additional use of β-cyclodextrin. Examination of the local irritant action indicated a "weak or absent" degree of local irritation.Conclusion. A local delivery system for sangviritrin has been developed for the treatment of infectious and inflammatory diseases of the oral cavity. |
| format | Article |
| id | doaj-art-367d1f085e284fc88068afafa632ec3f |
| institution | DOAJ |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2025-03-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-367d1f085e284fc88068afafa632ec3f2025-08-20T02:54:19ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492025-03-0114116017010.33380/2305-2066-2025-14-1-18511327Pharmaceutical development of sangviritrin spray for the treatment of inflammatory diseases of the oral cavityM. N. Anurova0Ya. A. Dorokhina1A. S. Gulenkov2N. B. Demina3L. A. Korol4P. G. Mizina5I. M. Sechenov First MSMU of the Ministry of Health of the Russian Federation (Sechenov University)I. M. Sechenov First MSMU of the Ministry of Health of the Russian Federation (Sechenov University)All-Russian Scientific Research Institute of Medicinal and Aromatic PlantsI. M. Sechenov First MSMU of the Ministry of Health of the Russian Federation (Sechenov University)I. M. Sechenov First MSMU of the Ministry of Health of the Russian Federation (Sechenov University)All-Russian Scientific Research Institute of Medicinal and Aromatic PlantsIntroduction. One of the most common bacterial infections includes acute and chronic tonsillitis, affecting 10 to 15 % of adults and approximately 20–25 % of children worldwide, according to the World Health Organization. The focus of this study was an original substance, sangviritrin, containing no less than 96.5 % of the sum of bisulfates of two alkaloids: sanguinarine and chelerythrine. Given the high antimicrobial activity of sangviritrin, the research aimed to develop a local delivery system based on this medicinal substance.Aim. The aim of this work was to develop an oral medicinal form of sangviritrin.Materials and Methods. Sangviritrin, produced by the All-Russian Scientific Research Institute of Medicinal and Aromatic Plants, was used as the active pharmaceutical ingredient. The selection of auxiliary components was carried out in accordance with the methodologies specified in the State Pharmacopoeia XV edition. The organoleptic properties of the substance and spray samples were studied using A. I. Tenzova's method. The local irritant action of the spray was assessed using the conjunctival test method on chinchilla rabbits weighing 3.5–4.3 kg. Quantitative determination of sangviritrin in the medicinal form was performed using spectrophotometric methods at a wavelength of 321 ± 2 nm on a spectrophotometer SPECORD® 200 PLUS (Analytik Jena GmbH+Co. KG, Germany).Results and Discussion. Optimal auxiliary component compositions were selected based on measurements of spray technological parameters. A comprehensive approach was justified for correcting the organoleptic properties of the substance, involving the introduction of a minimal amount of sweeteners and additional use of β-cyclodextrin. Examination of the local irritant action indicated a "weak or absent" degree of local irritation.Conclusion. A local delivery system for sangviritrin has been developed for the treatment of infectious and inflammatory diseases of the oral cavity.https://www.pharmjournal.ru/jour/article/view/2013spraysangviritrinlocal delivery systemantibiotic resistancebioadhesion |
| spellingShingle | M. N. Anurova Ya. A. Dorokhina A. S. Gulenkov N. B. Demina L. A. Korol P. G. Mizina Pharmaceutical development of sangviritrin spray for the treatment of inflammatory diseases of the oral cavity Разработка и регистрация лекарственных средств spray sangviritrin local delivery system antibiotic resistance bioadhesion |
| title | Pharmaceutical development of sangviritrin spray for the treatment of inflammatory diseases of the oral cavity |
| title_full | Pharmaceutical development of sangviritrin spray for the treatment of inflammatory diseases of the oral cavity |
| title_fullStr | Pharmaceutical development of sangviritrin spray for the treatment of inflammatory diseases of the oral cavity |
| title_full_unstemmed | Pharmaceutical development of sangviritrin spray for the treatment of inflammatory diseases of the oral cavity |
| title_short | Pharmaceutical development of sangviritrin spray for the treatment of inflammatory diseases of the oral cavity |
| title_sort | pharmaceutical development of sangviritrin spray for the treatment of inflammatory diseases of the oral cavity |
| topic | spray sangviritrin local delivery system antibiotic resistance bioadhesion |
| url | https://www.pharmjournal.ru/jour/article/view/2013 |
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