Alterations in the Antimicrobial Resistance Profile of Acinetobacter baumannii Strains Isolated from Intensive Care Unit Patients: Five-Year Follow-up in Cappadocia
Background: This study aims to determine alterations in the antibiotic resistance status of Acinetobacter baumannii strains isolated from lower respiratory tract samples of patients in intensive care units over the years. Methods: In this comprehensive study, A. baumannii strains isolated from aspi...
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Universidad Nacional Hermilio Valdizán de Huánuco
2024-10-01
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| Series: | Microbes, Infection and Chemotherapy |
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| Online Access: | https://revistas.unheval.edu.pe/index.php/mic/article/view/2235 |
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| author | Nazife Akman PELİN ÖZMEN Mustafa Türk |
| author_facet | Nazife Akman PELİN ÖZMEN Mustafa Türk |
| author_sort | Nazife Akman |
| collection | DOAJ |
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Background: This study aims to determine alterations in the antibiotic resistance status of Acinetobacter baumannii strains isolated from lower respiratory tract samples of patients in intensive care units over the years. Methods: In this comprehensive study, A. baumannii strains isolated from aspirate and sputum samples of patients hospitalized in intensive care units of a second-stage state hospital between January 2018 and December 2022 were meticulously and retrospectively investigated and analyzed for antimicrobial resistance. Results: The rate of aspirate and sputum samples in the study was 18.1% (754/4151); The positivity rate of cultures was 51.7% (390/754); The rate of those associated with A. baumannii was found to be 65.6% (256/390).. 90.2% of the isolates were isolated from the general intensive care unit (231/256). The rates of A. baumannii isolated from aspirate and sputum samples were 67.4% (213/316) and 58.1% (43/74), respectively. The carbapenem resistance rate in A. baumannii isolates grown in aspirate samples was 96.5%, fluoroquinolone resistance was 91.7%; The carbapenem resistance rate in sputum samples was 96.1% and fluoroquinolone resistance was 90.9%. The most effective antibiotics against A. baumannii strains isolated from both aspirate and sputum samples were colistin 100% (n=256), TMP/SXT 55.8% (143/256), tigecycline 50.3% (129/256), respectively. Conclusion: Our study reveals a concerning trend-a high frequency of multidrug-resistant A. baumannii isolates are being identified in the Central Anatolia region of our country. This high prevalence, which is a cause for immediate concern, underscores the urgent and immediate need for robust infection control measures to curb the spread of A. baumannii in hospitals.
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| format | Article |
| id | doaj-art-3679aed94561496e841adc8c8dbd4c91 |
| institution | OA Journals |
| issn | 2789-4274 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Universidad Nacional Hermilio Valdizán de Huánuco |
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| series | Microbes, Infection and Chemotherapy |
| spelling | doaj-art-3679aed94561496e841adc8c8dbd4c912025-08-20T01:47:26ZengUniversidad Nacional Hermilio Valdizán de HuánucoMicrobes, Infection and Chemotherapy2789-42742024-10-01410.54034/mic.e2235Alterations in the Antimicrobial Resistance Profile of Acinetobacter baumannii Strains Isolated from Intensive Care Unit Patients: Five-Year Follow-up in CappadociaNazife Akman0PELİN ÖZMEN1Mustafa Türk2Cappadocia University, Cappadocia Vocational School, Nevsehir, TurkeyNevsehir Haci Bektas Veli University Faculty of Dentistry, Medical Microbiology Department, Nevşehir, TurkeyNevsehir State Hospital, Nevsehir, Turkey Background: This study aims to determine alterations in the antibiotic resistance status of Acinetobacter baumannii strains isolated from lower respiratory tract samples of patients in intensive care units over the years. Methods: In this comprehensive study, A. baumannii strains isolated from aspirate and sputum samples of patients hospitalized in intensive care units of a second-stage state hospital between January 2018 and December 2022 were meticulously and retrospectively investigated and analyzed for antimicrobial resistance. Results: The rate of aspirate and sputum samples in the study was 18.1% (754/4151); The positivity rate of cultures was 51.7% (390/754); The rate of those associated with A. baumannii was found to be 65.6% (256/390).. 90.2% of the isolates were isolated from the general intensive care unit (231/256). The rates of A. baumannii isolated from aspirate and sputum samples were 67.4% (213/316) and 58.1% (43/74), respectively. The carbapenem resistance rate in A. baumannii isolates grown in aspirate samples was 96.5%, fluoroquinolone resistance was 91.7%; The carbapenem resistance rate in sputum samples was 96.1% and fluoroquinolone resistance was 90.9%. The most effective antibiotics against A. baumannii strains isolated from both aspirate and sputum samples were colistin 100% (n=256), TMP/SXT 55.8% (143/256), tigecycline 50.3% (129/256), respectively. Conclusion: Our study reveals a concerning trend-a high frequency of multidrug-resistant A. baumannii isolates are being identified in the Central Anatolia region of our country. This high prevalence, which is a cause for immediate concern, underscores the urgent and immediate need for robust infection control measures to curb the spread of A. baumannii in hospitals. https://revistas.unheval.edu.pe/index.php/mic/article/view/2235Acinetobacter baumanniicarbapenem resistanceintensive care unitlower respiratory tract |
| spellingShingle | Nazife Akman PELİN ÖZMEN Mustafa Türk Alterations in the Antimicrobial Resistance Profile of Acinetobacter baumannii Strains Isolated from Intensive Care Unit Patients: Five-Year Follow-up in Cappadocia Microbes, Infection and Chemotherapy Acinetobacter baumannii carbapenem resistance intensive care unit lower respiratory tract |
| title | Alterations in the Antimicrobial Resistance Profile of Acinetobacter baumannii Strains Isolated from Intensive Care Unit Patients: Five-Year Follow-up in Cappadocia |
| title_full | Alterations in the Antimicrobial Resistance Profile of Acinetobacter baumannii Strains Isolated from Intensive Care Unit Patients: Five-Year Follow-up in Cappadocia |
| title_fullStr | Alterations in the Antimicrobial Resistance Profile of Acinetobacter baumannii Strains Isolated from Intensive Care Unit Patients: Five-Year Follow-up in Cappadocia |
| title_full_unstemmed | Alterations in the Antimicrobial Resistance Profile of Acinetobacter baumannii Strains Isolated from Intensive Care Unit Patients: Five-Year Follow-up in Cappadocia |
| title_short | Alterations in the Antimicrobial Resistance Profile of Acinetobacter baumannii Strains Isolated from Intensive Care Unit Patients: Five-Year Follow-up in Cappadocia |
| title_sort | alterations in the antimicrobial resistance profile of acinetobacter baumannii strains isolated from intensive care unit patients five year follow up in cappadocia |
| topic | Acinetobacter baumannii carbapenem resistance intensive care unit lower respiratory tract |
| url | https://revistas.unheval.edu.pe/index.php/mic/article/view/2235 |
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