Polymorphic variants of the <i>hOGG1, APEX1, XPD, SOD2</i>, and <i>CAT</i> genes involved in DNA repair processes and antioxidant defense and their association with breast cancer risk
Breast cancer is one of the leading causes of mortality among women. The most frequently encountered tumors are luminal tumors. Associations of polymorphisms in the hOGG1 (rs1052133), APEX1 (rs1130409), XPD (rs13181), SOD2 (rs4880), and CAT (rs1001179) genes were studied in 313 nonsmoking postmenopa...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2024-07-01
|
| Series: | Вавиловский журнал генетики и селекции |
| Subjects: | |
| Online Access: | https://vavilov.elpub.ru/jour/article/view/4185 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832575007628197888 |
|---|---|
| author | А. А. Timofeeva V. I. Minina A. V. Torgunakova О. А. Soboleva R. А. Тitov Ya. А. Zakharova M. L. Bakanova А. N. Glushkov |
| author_facet | А. А. Timofeeva V. I. Minina A. V. Torgunakova О. А. Soboleva R. А. Тitov Ya. А. Zakharova M. L. Bakanova А. N. Glushkov |
| author_sort | А. А. Timofeeva |
| collection | DOAJ |
| description | Breast cancer is one of the leading causes of mortality among women. The most frequently encountered tumors are luminal tumors. Associations of polymorphisms in the hOGG1 (rs1052133), APEX1 (rs1130409), XPD (rs13181), SOD2 (rs4880), and CAT (rs1001179) genes were studied in 313 nonsmoking postmenopausal patients with luminal B subtype breast cancer. The control group consisted of 233 healthy nonsmoking postmenopausal women. Statistically significant associations of the XPD and APEX1 gene polymorphisms with the risk of developing luminal B Her2- negative subtype of breast cancer were observed in a log-additive inheritance model, while the CAT gene polymorphism showed an association in a dominant inheritance model (OR = 1.41; CI 95 %: 1.08–1.85; Padj.= 0.011; OR = 1.39; CI 95 %: 1.07–1.81; Padj = 0.013 и OR = 1.70; CI 95 %: 1.19–2.43; Padj = 0.004, respectively). In the group of elderly women (aged 60–74 years), an association of the CAT gene polymorphism with the risk of developing luminal B subtype of breast cancer was found in a log-additive inheritance model (OR = 1.87; 95 % CI: 1.22–2.85; Padj = 0.0024). Using MDR analysis, the most optimal statistically significant 3-locus model of gene-gene interactions in the development of luminal B Her2-negative subtype breast cancer was found. MDR analysis also showed a close interaction and mutual enhancement of effects between the APEX1 and SOD2 loci and the independence of the effects of these loci from the CAT locus in the formation of luminal B subtype breast cancer. |
| format | Article |
| id | doaj-art-36755870491b41019d7148b928e33389 |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-36755870491b41019d7148b928e333892025-02-01T09:58:13ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592024-07-0128442443210.18699/vjgb-24-481477Polymorphic variants of the <i>hOGG1, APEX1, XPD, SOD2</i>, and <i>CAT</i> genes involved in DNA repair processes and antioxidant defense and their association with breast cancer riskА. А. Timofeeva0V. I. Minina1A. V. Torgunakova2О. А. Soboleva3R. А. Тitov4Ya. А. Zakharova5M. L. Bakanova6А. N. Glushkov7Federal Research Center of Coal and Coal Chemistry of the Siberian Branch of the Russian Academy of SciencesFederal Research Center of Coal and Coal Chemistry of the Siberian Branch of the Russian Academy of Sciences ; Kemerovo State UniversityFederal Research Center of Coal and Coal Chemistry of the Siberian Branch of the Russian Academy of Sciences ; Kemerovo State UniversityFederal Research Center of Coal and Coal Chemistry of the Siberian Branch of the Russian Academy of SciencesFederal Research Center of Coal and Coal Chemistry of the Siberian Branch of the Russian Academy of Sciences ; Kemerovo State UniversityFederal Research Center of Coal and Coal Chemistry of the Siberian Branch of the Russian Academy of Sciences ; Kemerovo State UniversityFederal Research Center of Coal and Coal Chemistry of the Siberian Branch of the Russian Academy of SciencesFederal Research Center of Coal and Coal Chemistry of the Siberian Branch of the Russian Academy of SciencesBreast cancer is one of the leading causes of mortality among women. The most frequently encountered tumors are luminal tumors. Associations of polymorphisms in the hOGG1 (rs1052133), APEX1 (rs1130409), XPD (rs13181), SOD2 (rs4880), and CAT (rs1001179) genes were studied in 313 nonsmoking postmenopausal patients with luminal B subtype breast cancer. The control group consisted of 233 healthy nonsmoking postmenopausal women. Statistically significant associations of the XPD and APEX1 gene polymorphisms with the risk of developing luminal B Her2- negative subtype of breast cancer were observed in a log-additive inheritance model, while the CAT gene polymorphism showed an association in a dominant inheritance model (OR = 1.41; CI 95 %: 1.08–1.85; Padj.= 0.011; OR = 1.39; CI 95 %: 1.07–1.81; Padj = 0.013 и OR = 1.70; CI 95 %: 1.19–2.43; Padj = 0.004, respectively). In the group of elderly women (aged 60–74 years), an association of the CAT gene polymorphism with the risk of developing luminal B subtype of breast cancer was found in a log-additive inheritance model (OR = 1.87; 95 % CI: 1.22–2.85; Padj = 0.0024). Using MDR analysis, the most optimal statistically significant 3-locus model of gene-gene interactions in the development of luminal B Her2-negative subtype breast cancer was found. MDR analysis also showed a close interaction and mutual enhancement of effects between the APEX1 and SOD2 loci and the independence of the effects of these loci from the CAT locus in the formation of luminal B subtype breast cancer.https://vavilov.elpub.ru/jour/article/view/4185breast cancerluminal b subtypehogg1apex1xpdsod2cat. |
| spellingShingle | А. А. Timofeeva V. I. Minina A. V. Torgunakova О. А. Soboleva R. А. Тitov Ya. А. Zakharova M. L. Bakanova А. N. Glushkov Polymorphic variants of the <i>hOGG1, APEX1, XPD, SOD2</i>, and <i>CAT</i> genes involved in DNA repair processes and antioxidant defense and their association with breast cancer risk Вавиловский журнал генетики и селекции breast cancer luminal b subtype hogg1 apex1 xpd sod2 cat. |
| title | Polymorphic variants of the <i>hOGG1, APEX1, XPD, SOD2</i>, and <i>CAT</i> genes involved in DNA repair processes and antioxidant defense and their association with breast cancer risk |
| title_full | Polymorphic variants of the <i>hOGG1, APEX1, XPD, SOD2</i>, and <i>CAT</i> genes involved in DNA repair processes and antioxidant defense and their association with breast cancer risk |
| title_fullStr | Polymorphic variants of the <i>hOGG1, APEX1, XPD, SOD2</i>, and <i>CAT</i> genes involved in DNA repair processes and antioxidant defense and their association with breast cancer risk |
| title_full_unstemmed | Polymorphic variants of the <i>hOGG1, APEX1, XPD, SOD2</i>, and <i>CAT</i> genes involved in DNA repair processes and antioxidant defense and their association with breast cancer risk |
| title_short | Polymorphic variants of the <i>hOGG1, APEX1, XPD, SOD2</i>, and <i>CAT</i> genes involved in DNA repair processes and antioxidant defense and their association with breast cancer risk |
| title_sort | polymorphic variants of the i hogg1 apex1 xpd sod2 i and i cat i genes involved in dna repair processes and antioxidant defense and their association with breast cancer risk |
| topic | breast cancer luminal b subtype hogg1 apex1 xpd sod2 cat. |
| url | https://vavilov.elpub.ru/jour/article/view/4185 |
| work_keys_str_mv | AT aatimofeeva polymorphicvariantsoftheihogg1apex1xpdsod2iandicatigenesinvolvedindnarepairprocessesandantioxidantdefenseandtheirassociationwithbreastcancerrisk AT viminina polymorphicvariantsoftheihogg1apex1xpdsod2iandicatigenesinvolvedindnarepairprocessesandantioxidantdefenseandtheirassociationwithbreastcancerrisk AT avtorgunakova polymorphicvariantsoftheihogg1apex1xpdsod2iandicatigenesinvolvedindnarepairprocessesandantioxidantdefenseandtheirassociationwithbreastcancerrisk AT oasoboleva polymorphicvariantsoftheihogg1apex1xpdsod2iandicatigenesinvolvedindnarepairprocessesandantioxidantdefenseandtheirassociationwithbreastcancerrisk AT ratitov polymorphicvariantsoftheihogg1apex1xpdsod2iandicatigenesinvolvedindnarepairprocessesandantioxidantdefenseandtheirassociationwithbreastcancerrisk AT yaazakharova polymorphicvariantsoftheihogg1apex1xpdsod2iandicatigenesinvolvedindnarepairprocessesandantioxidantdefenseandtheirassociationwithbreastcancerrisk AT mlbakanova polymorphicvariantsoftheihogg1apex1xpdsod2iandicatigenesinvolvedindnarepairprocessesandantioxidantdefenseandtheirassociationwithbreastcancerrisk AT anglushkov polymorphicvariantsoftheihogg1apex1xpdsod2iandicatigenesinvolvedindnarepairprocessesandantioxidantdefenseandtheirassociationwithbreastcancerrisk |