A comprehensive review of the roles of T-cell immunity in preeclampsia
Preeclampsia (PE) is an obstetrical disorder that occurs after the 20th week of gestation. It is recognized as one of the “Great Obstetrical Syndromes” and principally contributes to maternal morbidity and mortality. PE has been associated with a range of immune disorders, including a preponderance...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1476123/full |
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| author | Xu Peng Ibeh Chinwe Oluchi-Amaka Joanne Kwak-Kim Joanne Kwak-Kim Xiuhua Yang |
| author_facet | Xu Peng Ibeh Chinwe Oluchi-Amaka Joanne Kwak-Kim Joanne Kwak-Kim Xiuhua Yang |
| author_sort | Xu Peng |
| collection | DOAJ |
| description | Preeclampsia (PE) is an obstetrical disorder that occurs after the 20th week of gestation. It is recognized as one of the “Great Obstetrical Syndromes” and principally contributes to maternal morbidity and mortality. PE has been associated with a range of immune disorders, including a preponderance of T helper (Th) 1 over Th2 cells and imbalanced levels of Th17 and T regulatory cells (Tregs). During pregnancy, T cells safeguard the placenta against immune rejection and aid embryo implantation while involved in pregnancy complications, such as PE. Promoting alloantigen-specific Treg cells is a potential preventive and therapeutic strategy for PE. However, ensuring the safety of mothers and infants is of the utmost importance since the risk-benefit ratio of reproductive and obstetric conditions differs significantly from that of immune diseases that pose a life-threatening risk. In this review, we systematically summarize the roles of T-cell immunity in the peripheral blood, reproductive tissues, and at the maternal-fetal interface of PE patients. Furthermore, the recent therapeutic approaches centered on targeting T cell immunity in PE are critically appraised. |
| format | Article |
| id | doaj-art-3673939e5ec54d618a9a01b023e2ef7c |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-3673939e5ec54d618a9a01b023e2ef7c2025-02-06T07:10:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.14761231476123A comprehensive review of the roles of T-cell immunity in preeclampsiaXu Peng0Ibeh Chinwe Oluchi-Amaka1Joanne Kwak-Kim2Joanne Kwak-Kim3Xiuhua Yang4Department of Obstetrics, The First Hospital of China Medical University, Shenyang, ChinaDepartment of Obstetrics, The First Hospital of China Medical University, Shenyang, ChinaReproductive Medicine and Immunology, Obstetrics and Gynecology, Clinical Sciences Department, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, United StatesClinical Immunology Laboratory, Foundational Sciences and Humanities, Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, United StatesDepartment of Obstetrics, The First Hospital of China Medical University, Shenyang, ChinaPreeclampsia (PE) is an obstetrical disorder that occurs after the 20th week of gestation. It is recognized as one of the “Great Obstetrical Syndromes” and principally contributes to maternal morbidity and mortality. PE has been associated with a range of immune disorders, including a preponderance of T helper (Th) 1 over Th2 cells and imbalanced levels of Th17 and T regulatory cells (Tregs). During pregnancy, T cells safeguard the placenta against immune rejection and aid embryo implantation while involved in pregnancy complications, such as PE. Promoting alloantigen-specific Treg cells is a potential preventive and therapeutic strategy for PE. However, ensuring the safety of mothers and infants is of the utmost importance since the risk-benefit ratio of reproductive and obstetric conditions differs significantly from that of immune diseases that pose a life-threatening risk. In this review, we systematically summarize the roles of T-cell immunity in the peripheral blood, reproductive tissues, and at the maternal-fetal interface of PE patients. Furthermore, the recent therapeutic approaches centered on targeting T cell immunity in PE are critically appraised.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1476123/fullpregnancypreeclampsiaT cellsTreg cellsTh17 cells |
| spellingShingle | Xu Peng Ibeh Chinwe Oluchi-Amaka Joanne Kwak-Kim Joanne Kwak-Kim Xiuhua Yang A comprehensive review of the roles of T-cell immunity in preeclampsia Frontiers in Immunology pregnancy preeclampsia T cells Treg cells Th17 cells |
| title | A comprehensive review of the roles of T-cell immunity in preeclampsia |
| title_full | A comprehensive review of the roles of T-cell immunity in preeclampsia |
| title_fullStr | A comprehensive review of the roles of T-cell immunity in preeclampsia |
| title_full_unstemmed | A comprehensive review of the roles of T-cell immunity in preeclampsia |
| title_short | A comprehensive review of the roles of T-cell immunity in preeclampsia |
| title_sort | comprehensive review of the roles of t cell immunity in preeclampsia |
| topic | pregnancy preeclampsia T cells Treg cells Th17 cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1476123/full |
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