Exploring the Current Situation and Developing Strategies for Behavior Change to Improve Antibiotic Use in West Africa: Protocol for a Multidisciplinary Interventional Research Project
BackgroundAntimicrobial resistance (AMR) is recognized as a global concern, with particularly severe consequences in low- and middle-income countries. Although it may occur naturally, it is also an anthropogenic problem linked to the irrational use of antibiotics in humans an...
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JMIR Publications
2025-07-01
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| Series: | JMIR Research Protocols |
| Online Access: | https://www.researchprotocols.org/2025/1/e66424 |
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| author | Maresa Neuerer Carine Baxerres Denise Dekker Blandine Bila Daniel Arhinful Leslie Mawuli Aglanu Charity Wiafe Akenten Boubacar Coulibaly Ali Sié John Humphrey Amuasi Aurélia Souares |
| author_facet | Maresa Neuerer Carine Baxerres Denise Dekker Blandine Bila Daniel Arhinful Leslie Mawuli Aglanu Charity Wiafe Akenten Boubacar Coulibaly Ali Sié John Humphrey Amuasi Aurélia Souares |
| author_sort | Maresa Neuerer |
| collection | DOAJ |
| description |
BackgroundAntimicrobial resistance (AMR) is recognized as a global concern, with particularly severe consequences in low- and middle-income countries. Although it may occur naturally, it is also an anthropogenic problem linked to the irrational use of antibiotics in humans and animal husbandry and the use of pesticides in plant agriculture. Generally, data on AMR and evidence of effective and feasible multifaceted interventions are limited in many African countries.
ObjectiveThis study aims at (1) assessing baseline data on AMR pathogens in Burkina Faso and Ghana; (2) understanding perceptions and quantifying use of antibiotics among health care workers, communities, and livestock farmers; and (3) defining and refining an AMR intervention using a design thinking approach.
MethodsThis multidisciplinary study will be conducted in two rural districts and will consist of two phases. First, baseline data will be collected on AMR pathogens along dominant food production chains. extended-spectrum beta-lactamase (ESBL)–producing Escherichia coli and Klebsiella pneumoniae will be selected as indicator mechanisms for AMR because of their high occurrence among animals and humans. The perception and understanding of AMR and antibiotic use among different stakeholders and community members will be assessed using epidemiologic and socio-anthropological methods. Qualitative methods will include participant observations, in-depth and key informant interviews, and focus group discussions. The quantitative part will consist of the development of an inventory of circulating antibiotics and a household survey. Second, key informant and in-depth interviews will be conducted with One Health stakeholders in preparation for the intervention development. Subsequently, multidisciplinary “design teams” will develop ideas for an intervention on AMR using a design thinking approach.
ResultsData collection started in April 2022. The analysis of microbiological, anthropological, and socio-epidemiological data is ongoing in both countries. The intervention development has been initiated in Ghana but has not started yet in Burkina Faso. All results are planned to be submitted to peer-reviewed journals by December 2025. First, manuscripts will be published for each discipline. Afterward, the results of the 3 disciplines will be combined in multidisciplinary papers, and a publication of the evaluation of the intervention will follow.
ConclusionsOwing to the multifactorial nature of AMR, different perspectives need to be considered to develop a holistic context-based intervention that is tailored to local needs. This study stands out in its combination of different disciplinary and epistemological perspectives following the One Health paradigm and taking a design thinking approach to develop an intervention. Thereby, collaboration across disciplines and social levels and a participatory bottom-up approach will be promoted to achieve a common understanding of problems and needs and to develop an accepted and efficacious intervention. The national AMR networks and policymakers will be continuously involved in the project.
International Registered Report Identifier (IRRID)DERR1-10.2196/66424 |
| format | Article |
| id | doaj-art-3672fa2f00e944bebb02be43a5c31c33 |
| institution | Kabale University |
| issn | 1929-0748 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | JMIR Publications |
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| series | JMIR Research Protocols |
| spelling | doaj-art-3672fa2f00e944bebb02be43a5c31c332025-08-20T03:56:46ZengJMIR PublicationsJMIR Research Protocols1929-07482025-07-0114e6642410.2196/66424Exploring the Current Situation and Developing Strategies for Behavior Change to Improve Antibiotic Use in West Africa: Protocol for a Multidisciplinary Interventional Research ProjectMaresa Neuererhttps://orcid.org/0000-0001-8548-2085Carine Baxerreshttps://orcid.org/0000-0003-3023-3449Denise Dekkerhttps://orcid.org/0000-0001-5432-3217Blandine Bilahttps://orcid.org/0000-0001-9419-0244Daniel Arhinfulhttps://orcid.org/0000-0002-5496-3289Leslie Mawuli Aglanuhttps://orcid.org/0000-0003-3302-7034Charity Wiafe Akentenhttps://orcid.org/0000-0001-6113-7391Boubacar Coulibalyhttps://orcid.org/0000-0001-9868-6503Ali Siéhttps://orcid.org/0000-0002-3959-2520John Humphrey Amuasihttps://orcid.org/0000-0002-8640-2662Aurélia Souareshttps://orcid.org/0000-0002-3984-5866 BackgroundAntimicrobial resistance (AMR) is recognized as a global concern, with particularly severe consequences in low- and middle-income countries. Although it may occur naturally, it is also an anthropogenic problem linked to the irrational use of antibiotics in humans and animal husbandry and the use of pesticides in plant agriculture. Generally, data on AMR and evidence of effective and feasible multifaceted interventions are limited in many African countries. ObjectiveThis study aims at (1) assessing baseline data on AMR pathogens in Burkina Faso and Ghana; (2) understanding perceptions and quantifying use of antibiotics among health care workers, communities, and livestock farmers; and (3) defining and refining an AMR intervention using a design thinking approach. MethodsThis multidisciplinary study will be conducted in two rural districts and will consist of two phases. First, baseline data will be collected on AMR pathogens along dominant food production chains. extended-spectrum beta-lactamase (ESBL)–producing Escherichia coli and Klebsiella pneumoniae will be selected as indicator mechanisms for AMR because of their high occurrence among animals and humans. The perception and understanding of AMR and antibiotic use among different stakeholders and community members will be assessed using epidemiologic and socio-anthropological methods. Qualitative methods will include participant observations, in-depth and key informant interviews, and focus group discussions. The quantitative part will consist of the development of an inventory of circulating antibiotics and a household survey. Second, key informant and in-depth interviews will be conducted with One Health stakeholders in preparation for the intervention development. Subsequently, multidisciplinary “design teams” will develop ideas for an intervention on AMR using a design thinking approach. ResultsData collection started in April 2022. The analysis of microbiological, anthropological, and socio-epidemiological data is ongoing in both countries. The intervention development has been initiated in Ghana but has not started yet in Burkina Faso. All results are planned to be submitted to peer-reviewed journals by December 2025. First, manuscripts will be published for each discipline. Afterward, the results of the 3 disciplines will be combined in multidisciplinary papers, and a publication of the evaluation of the intervention will follow. ConclusionsOwing to the multifactorial nature of AMR, different perspectives need to be considered to develop a holistic context-based intervention that is tailored to local needs. This study stands out in its combination of different disciplinary and epistemological perspectives following the One Health paradigm and taking a design thinking approach to develop an intervention. Thereby, collaboration across disciplines and social levels and a participatory bottom-up approach will be promoted to achieve a common understanding of problems and needs and to develop an accepted and efficacious intervention. The national AMR networks and policymakers will be continuously involved in the project. International Registered Report Identifier (IRRID)DERR1-10.2196/66424https://www.researchprotocols.org/2025/1/e66424 |
| spellingShingle | Maresa Neuerer Carine Baxerres Denise Dekker Blandine Bila Daniel Arhinful Leslie Mawuli Aglanu Charity Wiafe Akenten Boubacar Coulibaly Ali Sié John Humphrey Amuasi Aurélia Souares Exploring the Current Situation and Developing Strategies for Behavior Change to Improve Antibiotic Use in West Africa: Protocol for a Multidisciplinary Interventional Research Project JMIR Research Protocols |
| title | Exploring the Current Situation and Developing Strategies for Behavior Change to Improve Antibiotic Use in West Africa: Protocol for a Multidisciplinary Interventional Research Project |
| title_full | Exploring the Current Situation and Developing Strategies for Behavior Change to Improve Antibiotic Use in West Africa: Protocol for a Multidisciplinary Interventional Research Project |
| title_fullStr | Exploring the Current Situation and Developing Strategies for Behavior Change to Improve Antibiotic Use in West Africa: Protocol for a Multidisciplinary Interventional Research Project |
| title_full_unstemmed | Exploring the Current Situation and Developing Strategies for Behavior Change to Improve Antibiotic Use in West Africa: Protocol for a Multidisciplinary Interventional Research Project |
| title_short | Exploring the Current Situation and Developing Strategies for Behavior Change to Improve Antibiotic Use in West Africa: Protocol for a Multidisciplinary Interventional Research Project |
| title_sort | exploring the current situation and developing strategies for behavior change to improve antibiotic use in west africa protocol for a multidisciplinary interventional research project |
| url | https://www.researchprotocols.org/2025/1/e66424 |
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