Anti-inflammatory coupled anti-angiogenic airway stent effectively suppresses tracheal in-stents restenosis
Abstract Excessive vascularization during tracheal in-stent restenosis (TISR) is a significant but frequently overlooked issue. We developed an anti-inflammatory coupled anti-angiogenic airway stent (PAGL) incorporating anlotinib hydrochloride and silver nanoparticles using advanced electrospinning...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-024-03087-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571293166206976 |
|---|---|
| author | Yanan Zhao Yiming Liu Jiheng Shan Xiaohong Xu Chengzhi Zhang Zaoqu Liu Xiaomeng Li Zhaoqian Zhong Yanxia Gao Kewei Ren Dechao Jiao Jianzhuang Ren Ping Wu Yong Jiang Xinwei Han |
| author_facet | Yanan Zhao Yiming Liu Jiheng Shan Xiaohong Xu Chengzhi Zhang Zaoqu Liu Xiaomeng Li Zhaoqian Zhong Yanxia Gao Kewei Ren Dechao Jiao Jianzhuang Ren Ping Wu Yong Jiang Xinwei Han |
| author_sort | Yanan Zhao |
| collection | DOAJ |
| description | Abstract Excessive vascularization during tracheal in-stent restenosis (TISR) is a significant but frequently overlooked issue. We developed an anti-inflammatory coupled anti-angiogenic airway stent (PAGL) incorporating anlotinib hydrochloride and silver nanoparticles using advanced electrospinning technology. PAGL exhibited hydrophobic surface properties, exceptional mechanical strength, and appropriate drug-release kinetics. Moreover, it demonstrated a remarkable eradication effect against methicillin-resistant Staphylococcus aureus. It also displayed anti-proliferative and anti-angiogenic properties on human umbilical vein endothelial cells and lung fibroblasts. PAGL was implanted into the tracheae of New Zealand rabbits to evaluate its efficacy in inhibiting bacterial infection, suppressing the inflammatory response, reducing angiogenesis, and attenuating excessive fibroblast activation. RNA sequencing analysis revealed a significant downregulation of genes associated with fibrosis, intimal hyperplasia, and cell migration following PAGL treatment. This study provides insight into the development of airway stents that target angiogenesis and inflammation to address problems associated with TISR effectively and have the potential for clinical translation. |
| format | Article |
| id | doaj-art-3671721bc220442c89259af61653e3f9 |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-3671721bc220442c89259af61653e3f92025-02-02T12:41:04ZengBMCJournal of Nanobiotechnology1477-31552025-01-0123112110.1186/s12951-024-03087-yAnti-inflammatory coupled anti-angiogenic airway stent effectively suppresses tracheal in-stents restenosisYanan Zhao0Yiming Liu1Jiheng Shan2Xiaohong Xu3Chengzhi Zhang4Zaoqu Liu5Xiaomeng Li6Zhaoqian Zhong7Yanxia Gao8Kewei Ren9Dechao Jiao10Jianzhuang Ren11Ping Wu12Yong Jiang13Xinwei Han14Department of Interventional Radiology, Key Laboratory of Interventional Radiology of Henan Province, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Interventional Radiology, Key Laboratory of Interventional Radiology of Henan Province, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Interventional Radiology, Key Laboratory of Interventional Radiology of Henan Province, The First Affiliated Hospital of Zhengzhou UniversityState Key Laboratory of Antiviral Drugs, Henan Key Laboratory of Critical Care Medicine, Henan International Joint Laboratory of Infection and Immmunology, Department of Emergency Medicine, The First Affiliated Hospital, Zhengzhou UniversityDepartment of Interventional Radiology, Key Laboratory of Interventional Radiology of Henan Province, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Interventional Radiology, Key Laboratory of Interventional Radiology of Henan Province, The First Affiliated Hospital of Zhengzhou UniversitySchool of Mechanics and Safety Engineering, Zhengzhou UniversityState Key Laboratory of Antiviral Drugs, Henan Key Laboratory of Critical Care Medicine, Henan International Joint Laboratory of Infection and Immmunology, Department of Emergency Medicine, The First Affiliated Hospital, Zhengzhou UniversityState Key Laboratory of Antiviral Drugs, Henan Key Laboratory of Critical Care Medicine, Henan International Joint Laboratory of Infection and Immmunology, Department of Emergency Medicine, The First Affiliated Hospital, Zhengzhou UniversityDepartment of Interventional Radiology, Key Laboratory of Interventional Radiology of Henan Province, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Interventional Radiology, Key Laboratory of Interventional Radiology of Henan Province, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Interventional Radiology, Key Laboratory of Interventional Radiology of Henan Province, The First Affiliated Hospital of Zhengzhou UniversityNational Key Laboratory of Macromolecular Drug Development and Manufacturing, School of Pharmaceutical Science, Wenzhou Medical UniversityState Key Laboratory of Antiviral Drugs, Henan Key Laboratory of Critical Care Medicine, Henan International Joint Laboratory of Infection and Immmunology, Department of Emergency Medicine, The First Affiliated Hospital, Zhengzhou UniversityDepartment of Interventional Radiology, Key Laboratory of Interventional Radiology of Henan Province, The First Affiliated Hospital of Zhengzhou UniversityAbstract Excessive vascularization during tracheal in-stent restenosis (TISR) is a significant but frequently overlooked issue. We developed an anti-inflammatory coupled anti-angiogenic airway stent (PAGL) incorporating anlotinib hydrochloride and silver nanoparticles using advanced electrospinning technology. PAGL exhibited hydrophobic surface properties, exceptional mechanical strength, and appropriate drug-release kinetics. Moreover, it demonstrated a remarkable eradication effect against methicillin-resistant Staphylococcus aureus. It also displayed anti-proliferative and anti-angiogenic properties on human umbilical vein endothelial cells and lung fibroblasts. PAGL was implanted into the tracheae of New Zealand rabbits to evaluate its efficacy in inhibiting bacterial infection, suppressing the inflammatory response, reducing angiogenesis, and attenuating excessive fibroblast activation. RNA sequencing analysis revealed a significant downregulation of genes associated with fibrosis, intimal hyperplasia, and cell migration following PAGL treatment. This study provides insight into the development of airway stents that target angiogenesis and inflammation to address problems associated with TISR effectively and have the potential for clinical translation.https://doi.org/10.1186/s12951-024-03087-yAnlotinibSilver nanoparticlesAirway stentTracheal in-stents restenosis |
| spellingShingle | Yanan Zhao Yiming Liu Jiheng Shan Xiaohong Xu Chengzhi Zhang Zaoqu Liu Xiaomeng Li Zhaoqian Zhong Yanxia Gao Kewei Ren Dechao Jiao Jianzhuang Ren Ping Wu Yong Jiang Xinwei Han Anti-inflammatory coupled anti-angiogenic airway stent effectively suppresses tracheal in-stents restenosis Journal of Nanobiotechnology Anlotinib Silver nanoparticles Airway stent Tracheal in-stents restenosis |
| title | Anti-inflammatory coupled anti-angiogenic airway stent effectively suppresses tracheal in-stents restenosis |
| title_full | Anti-inflammatory coupled anti-angiogenic airway stent effectively suppresses tracheal in-stents restenosis |
| title_fullStr | Anti-inflammatory coupled anti-angiogenic airway stent effectively suppresses tracheal in-stents restenosis |
| title_full_unstemmed | Anti-inflammatory coupled anti-angiogenic airway stent effectively suppresses tracheal in-stents restenosis |
| title_short | Anti-inflammatory coupled anti-angiogenic airway stent effectively suppresses tracheal in-stents restenosis |
| title_sort | anti inflammatory coupled anti angiogenic airway stent effectively suppresses tracheal in stents restenosis |
| topic | Anlotinib Silver nanoparticles Airway stent Tracheal in-stents restenosis |
| url | https://doi.org/10.1186/s12951-024-03087-y |
| work_keys_str_mv | AT yananzhao antiinflammatorycoupledantiangiogenicairwaystenteffectivelysuppressestrachealinstentsrestenosis AT yimingliu antiinflammatorycoupledantiangiogenicairwaystenteffectivelysuppressestrachealinstentsrestenosis AT jihengshan antiinflammatorycoupledantiangiogenicairwaystenteffectivelysuppressestrachealinstentsrestenosis AT xiaohongxu antiinflammatorycoupledantiangiogenicairwaystenteffectivelysuppressestrachealinstentsrestenosis AT chengzhizhang antiinflammatorycoupledantiangiogenicairwaystenteffectivelysuppressestrachealinstentsrestenosis AT zaoquliu antiinflammatorycoupledantiangiogenicairwaystenteffectivelysuppressestrachealinstentsrestenosis AT xiaomengli antiinflammatorycoupledantiangiogenicairwaystenteffectivelysuppressestrachealinstentsrestenosis AT zhaoqianzhong antiinflammatorycoupledantiangiogenicairwaystenteffectivelysuppressestrachealinstentsrestenosis AT yanxiagao antiinflammatorycoupledantiangiogenicairwaystenteffectivelysuppressestrachealinstentsrestenosis AT keweiren antiinflammatorycoupledantiangiogenicairwaystenteffectivelysuppressestrachealinstentsrestenosis AT dechaojiao antiinflammatorycoupledantiangiogenicairwaystenteffectivelysuppressestrachealinstentsrestenosis AT jianzhuangren antiinflammatorycoupledantiangiogenicairwaystenteffectivelysuppressestrachealinstentsrestenosis AT pingwu antiinflammatorycoupledantiangiogenicairwaystenteffectivelysuppressestrachealinstentsrestenosis AT yongjiang antiinflammatorycoupledantiangiogenicairwaystenteffectivelysuppressestrachealinstentsrestenosis AT xinweihan antiinflammatorycoupledantiangiogenicairwaystenteffectivelysuppressestrachealinstentsrestenosis |