Compensatory enhancement of orexinergic system functionality induced by amyloid-β protein: a neuroprotective response in Alzheimer’s disease

Compensatory enhancement of orexinergic system functionality induced by amyloid-β protein: a neuroprotective response in Alzheimer’s disease

BackgroundAmyloid-β protein (Aβ) accumulation is a defining characteristic of Alzheimer’s disease (AD), resulting in neurodegeneration and a decline in cognitive function. Given orexin’s well-documented role in enhancing memory and cognition, this study investigates its potential to regulate Aβ-indu...

Full description

Saved in:

Bibliographic Details
Main Authors:	Chenyu Zhuang, Hengyu Yan, Jiayu Lu, Yifan Zhou, Yanqing Liu, Guoshan Shi, Yan Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Series:	Frontiers in Physiology
Subjects:	Alzheimer’s disease orexin (hypocretin) amyloid-β protein cognitive impairment neuroprotection
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2025.1529981/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Can serum orexin levels be used as a marker in childhood epilepsy?
by: Mutluay Arslan, et al.
Published: (2025-01-01)

Effects of Traumatic Brain Injury on the Orexin/Hypocretin System
by: Rebecca T. Somach, et al.
Published: (2025-01-01)

Hypocretin: a promising target for the regulation of homeostasis
by: Yutong Wang, et al.
Published: (2025-08-01)

Role of Hypothalamus in Acupuncture’s Effects
by: Ryan Bae, et al.
Published: (2025-01-01)

Fentanyl demand and seeking in female rats: Role of the orexin system and estrous cycle
by: David De Sa Nogueira, et al.
Published: (2024-12-01)

Reduction of orexin-expressing neurons and a unique sleep phenotype in the Tg-SwDI mouse model of Alzheimer’s disease
by: Yan Wu, et al.
Published: (2025-02-01)

Neuroprotective potential of quercetin in Alzheimer’s disease: targeting oxidative stress, mitochondrial dysfunction, and amyloid-β aggregation
by: Mohd Adnan, et al.
Published: (2025-06-01)

Potential role of ghrelin in neuroprotection and cognitive function: implications for diabetic cognitive impairment
by: Yuhan Zhang, et al.
Published: (2025-02-01)

Sleep disorders and Alzheimer’s disease: relationship and mechanisms involving neuroinflammation, orexin and Aβ
by: Wenjing Zhang, et al.
Published: (2025-06-01)

Dietary docosahexaenoic acid and dihydrocaffeic acid, a chlorogenic acid derivative, confer additive neuroprotection against β-amyloid in SH-SY5Y cells
by: Edwin Estefan Reza-Zaldívar, et al.
Published: (2025-12-01)

Effects of the dual orexin receptor antagonist DORA‐22 on sleep in 5XFAD mice
by: Marilyn J. Duncan, et al.
Published: (2019-01-01)

Potential role of Amyloid-β on the association between Orexin-A and blood-brain barrier leakage of globus pallidus in Alzheimer’s disease and dementia with lewy bodies
by: Jinghuan Gan, et al.
Published: (2025-06-01)

Exploring the Neuroprotective Effects of Grape Seed Procyanidins on Amyloid-β-Induced Toxicity in <i>Caenorhabditis elegans</i>
by: Susana González-Manzano, et al.
Published: (2024-11-01)

Tumor cell apoptosis mediated by the orexins
by: A. S. Diatlova, et al.
Published: (2021-06-01)

Recent advances in immunotherapy targeting amyloid-beta and tauopathies in Alzheimer’s disease
by: Sha Sha, et al.
Published: (2026-02-01)

Plasma amyloid‐β oligomerization tendency as a potential predictor for conversion from mild cognitive impairment to Alzheimer's dementia: Findings from the GMCII cohort
by: Yuhan Xie, et al.
Published: (2025-01-01)

Reevaluating the role of amyloid β-peptides in Alzheimer’s disease: from pathogenic agents to protective chelation mechanisms
by: Franco Cavaleri
Published: (2025-03-01)

The impact of kidney function on Alzheimer’s disease blood biomarkers: implications for predicting amyloid-β positivity
by: Burak Arslan, et al.
Published: (2025-02-01)

Familial Narcolepsy in Dogo Argentino Dogs Is Caused by a Tandem Duplication Mutation in HCRTR2
by: Alejandra Mondino, et al.
Published: (2025-03-01)

Amyloid-beta 40 as a biomarker of cognitive impairment in acute ischemic stroke
by: Aleksey A. Kulesh, et al.
Published: (2017-10-01)

Health-related quality of life in patients with narcolepsy types 1 and 2 from a Sleep Center in Brazil
by: Renata Carvalho CREMASCHI, et al.
Published: (2020-06-01)

A novel perspective in stroke neuroprotection: Leveraging hypoxic pocket insights for studying preconditioning and postconditioning
by: Heng Zhao, et al.
Published: (2024-12-01)

The Role of Selected Flavonoids in Modulating Neuroinflammation in Alzheimer’s Disease: Mechanisms and Therapeutic Potential
by: Joanna Kruszka, et al.
Published: (2025-05-01)

Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI)
by: Jie Liu, et al.
Published: (2023-12-01)

The Efficacy of Anti-amyloid Monoclonal Antibodies in Early Alzheimer’s Dementia: A Systematic Review
by: Alyaa Mostafa, et al.
Published: (2025-05-01)

β-Amyloids and Immune Responses Associated with Alzheimer’s Disease
by: Elizaveta Kolobova, et al.
Published: (2024-09-01)

Lead-induced hypertension and cognitive dysfunction: brain amyloid pathology
by: Yunbo Zhang, et al.
Published: (2025-08-01)

New Tacrine Dimers Alleviate the Intracellular Amyloid-β-induced Cognitive Disturbance and Oxidative Stress in Mice
by: ANA ELISA GONÇALVES, et al.
Published: (2025-07-01)

Phototherapy via Modulation of β‐Amyloid in Combating Alzheimer's Disease
by: Yunhua Zhang, et al.
Published: (2025-05-01)

Alteration of Metabolic Profile in Patients with Narcolepsy Type 1
by: Md Abdul Hakim, et al.
Published: (2025-06-01)

Amyloid-β Inhibiting Peptides: An Innovative Strategy for Alzheimer’s Disease Treatment
by: Sajjad Molavipordanjani, et al.
Published: (2023-11-01)

Faster decline of very prodromal dementia with Lewy bodies when amyloid positive
by: Frédéric Blanc, et al.
Published: (2025-04-01)

Watchful waiting in laryngo‐tracheobronchial amyloid: A case report
by: Dylan Beinart, et al.
Published: (2024-11-01)

Nanomaterials in targeting amyloid-β oligomers: current advances and future directions for Alzheimer's disease diagnosis and therapy
by: Shiwani Randhawa, et al.
Published: (2025-04-01)

Unraveling the complex role of microglia in Alzheimer’s disease: amyloid β metabolism and plaque formation
by: Sho Takatori, et al.
Published: (2025-05-01)

Bidirectional causality of physical exercise in retinal neuroprotection
by: Stephen K. Agadagba, et al.
Published: (2025-12-01)

Amyloid immunotherapy for Alzheimer's disease: the case for cautious adoption
by: Jonathan M. Schott, et al.
Published: (2025-05-01)

The abnormal accumulation of pathological proteins and compensatory functional connectivity enhancement of insula subdivisions in mild cognitive impairment
by: Darui Zheng, et al.
Published: (2025-03-01)

Systematic review of amyloid-beta clearance proteins from the brain to the periphery: implications for Alzheimer’s disease diagnosis and therapeutic targets
by: Letian Huang, et al.
Published: (2025-12-01)

Long-term follow-up of retinal amyloid angiopathy in a large Chinese family with hereditary amyloid transthyretin
by: Jiangning Xu, et al.
Published: (2025-04-01)