Clinical Characteristics and Prognosis of Primary Esophageal Small Cell Carcinoma
ObjectiveTo investigate the clinical characteristics and prognostic factors of the limited-stage disease (LD) and extensive-stage disease (ED) of primary esophageal small cell carcinoma (PESCC). MethodsThe clinical data and follow-up information of 72 patients with PESCC were retrospectively analyze...
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Magazine House of Cancer Research on Prevention and Treatment
2024-12-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2024.24.0573 |
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| author | Min QUAN Jiayuan TANG Hong CHEN |
| author_facet | Min QUAN Jiayuan TANG Hong CHEN |
| author_sort | Min QUAN |
| collection | DOAJ |
| description | ObjectiveTo investigate the clinical characteristics and prognostic factors of the limited-stage disease (LD) and extensive-stage disease (ED) of primary esophageal small cell carcinoma (PESCC). MethodsThe clinical data and follow-up information of 72 patients with PESCC were retrospectively analyzed. Chi-square test was used to compare the baseline data of patients with LD and ED, Kaplan-Meier method was employed to draw the survival curve of both groups, and Log-rank test was employed to compare survival rates between groups. Univariate and multivariate Cox regression methods were used to analyze the factors affecting the overall survival (OS) of patients with LD and ED. ResultsA total of 49 patients with LD and 23 patients with ED were included in this study. The median survival time of patients with LD was 18.300 months and that of patients with ED was 10.903 months (P=0.029). Total protein (TP) value (HR=0.890, 95%CI: 0.805−0.983, P=0.022) and chemotherapy cycle number (HR=0.388, 95%CI: 0.187−0.807, P=0.011) were independent prognostic factors of patients with LD. Systemic immune-inflammation index (SII) (HR=1.002, 95%CI: 1.000−1.004, P=0.007) and C-reactive protein (CRP) (HR=1.065, 95%CI: 1.021−1.111, P=0.004) were independent prognostic factors of patients with ED. ConclusionThe malignant degree of PESCC is high, and prognosis is poor. Patients with LD and ED have different prognostic factors. Total protein value and chemotherapy cycle are independent prognostic factors of patients with LD. SII and CRP are independent prognostic factors of patients with ED. |
| format | Article |
| id | doaj-art-366c2e42fcd04d60a83a38fa431a50c8 |
| institution | OA Journals |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-366c2e42fcd04d60a83a38fa431a50c82025-08-20T02:34:54ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782024-12-0151121021102710.3971/j.issn.1000-8578.2024.24.057320240573Clinical Characteristics and Prognosis of Primary Esophageal Small Cell CarcinomaMin QUAN0Jiayuan TANG1Hong CHEN2School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaDepartment of Integrated Chinese and Western Medicine, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610042, ChinaObjectiveTo investigate the clinical characteristics and prognostic factors of the limited-stage disease (LD) and extensive-stage disease (ED) of primary esophageal small cell carcinoma (PESCC). MethodsThe clinical data and follow-up information of 72 patients with PESCC were retrospectively analyzed. Chi-square test was used to compare the baseline data of patients with LD and ED, Kaplan-Meier method was employed to draw the survival curve of both groups, and Log-rank test was employed to compare survival rates between groups. Univariate and multivariate Cox regression methods were used to analyze the factors affecting the overall survival (OS) of patients with LD and ED. ResultsA total of 49 patients with LD and 23 patients with ED were included in this study. The median survival time of patients with LD was 18.300 months and that of patients with ED was 10.903 months (P=0.029). Total protein (TP) value (HR=0.890, 95%CI: 0.805−0.983, P=0.022) and chemotherapy cycle number (HR=0.388, 95%CI: 0.187−0.807, P=0.011) were independent prognostic factors of patients with LD. Systemic immune-inflammation index (SII) (HR=1.002, 95%CI: 1.000−1.004, P=0.007) and C-reactive protein (CRP) (HR=1.065, 95%CI: 1.021−1.111, P=0.004) were independent prognostic factors of patients with ED. ConclusionThe malignant degree of PESCC is high, and prognosis is poor. Patients with LD and ED have different prognostic factors. Total protein value and chemotherapy cycle are independent prognostic factors of patients with LD. SII and CRP are independent prognostic factors of patients with ED.http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2024.24.0573primary esophageal small cell carcinomalimited-diseaseextensive-diseaseprognosis |
| spellingShingle | Min QUAN Jiayuan TANG Hong CHEN Clinical Characteristics and Prognosis of Primary Esophageal Small Cell Carcinoma Zhongliu Fangzhi Yanjiu primary esophageal small cell carcinoma limited-disease extensive-disease prognosis |
| title | Clinical Characteristics and Prognosis of Primary Esophageal Small Cell Carcinoma |
| title_full | Clinical Characteristics and Prognosis of Primary Esophageal Small Cell Carcinoma |
| title_fullStr | Clinical Characteristics and Prognosis of Primary Esophageal Small Cell Carcinoma |
| title_full_unstemmed | Clinical Characteristics and Prognosis of Primary Esophageal Small Cell Carcinoma |
| title_short | Clinical Characteristics and Prognosis of Primary Esophageal Small Cell Carcinoma |
| title_sort | clinical characteristics and prognosis of primary esophageal small cell carcinoma |
| topic | primary esophageal small cell carcinoma limited-disease extensive-disease prognosis |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2024.24.0573 |
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