Osteosarcopenia as a risk factor for depression: Longitudinal findings from the SHARE study
Background: Osteosarcopenia (i.e., the co-existence of osteoporosis and sarcopenia) and depression are highly prevalent among older people. However, the association between osteosarcopenia and depression in older people is largely unknown. Therefore, the present study aims to investigate this possib...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Bone Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352187225000257 |
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| author | Nicola Veronese Francesco Saverio Ragusa Shaun Sabico Ligia Juliana Dominguez Mario Barbagallo Gustavo Duque Lee Smith Nasser Al-Daghri |
| author_facet | Nicola Veronese Francesco Saverio Ragusa Shaun Sabico Ligia Juliana Dominguez Mario Barbagallo Gustavo Duque Lee Smith Nasser Al-Daghri |
| author_sort | Nicola Veronese |
| collection | DOAJ |
| description | Background: Osteosarcopenia (i.e., the co-existence of osteoporosis and sarcopenia) and depression are highly prevalent among older people. However, the association between osteosarcopenia and depression in older people is largely unknown. Therefore, the present study aims to investigate this possible association in a representative sample of the older adult population in Europe and Israel. Methods: Osteosarcopenia was defined as the concomitant presence of osteoporosis and sarcopenia; depressive symptoms in the SHARE study were self-reported using the EURO-D scale. The association between the presence of osteosarcopenia at baseline in people free from depression and incident depression during 12 years of follow-up was analyzed using a Cox's regression analysis, adjusting for several baseline covariates. Results: 16,452 participants were included (mean age 63.7, SD 9.6; females 50.6 %). During the follow-up period, 5056 participants (31.1 % of the initial population) became depressed. People affected by osteosarcopenia became depressed in more than half of the cases compared to a quarter of controls. After adjusting for several potential baseline confounding variables, only sarcopenia (HR, hazard ratio = 1.17; 95 % CI, confidence intervals 1.04–1.32; p = 0.009) and osteosarcopenia (HR = 1.27; CI 95 % 1.12–1.58; p = 0.003) were significantly associated with a higher risk of depression. Limitations: Definition of sarcopenia using an anthropometric equation; definition of depression using the EURO-D scale. Conclusions: The present study identified a significant association between osteosarcopenia and depression over 12 years of follow-up, mainly driven by sarcopenia. If future research confirms the present findings, it may then be prudent to target those with osteosarcopenia to aid in the prevention of onset depression. |
| format | Article |
| id | doaj-art-366a8f027bfc471a98f4b7ffdcccd392 |
| institution | DOAJ |
| issn | 2352-1872 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Bone Reports |
| spelling | doaj-art-366a8f027bfc471a98f4b7ffdcccd3922025-08-20T03:21:00ZengElsevierBone Reports2352-18722025-06-012510184810.1016/j.bonr.2025.101848Osteosarcopenia as a risk factor for depression: Longitudinal findings from the SHARE studyNicola Veronese0Francesco Saverio Ragusa1Shaun Sabico2Ligia Juliana Dominguez3Mario Barbagallo4Gustavo Duque5Lee Smith6Nasser Al-Daghri7Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90127 Palermo, Italy; Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; Corresponding author at: Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Via del Vespro, 141, 90127 Palermo, Italy.Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90127 Palermo, ItalyChair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Medicine and Surgery, Kore University of Enna, 94100 Enna, ItalyGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90127 Palermo, ItalyBone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, QC, Canada; Dr Joseph Kaufmann Chair in Geriatric Medicine, Department of Medicine, McGill University, Montreal, QC, CanadaCentre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge, UKChair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaBackground: Osteosarcopenia (i.e., the co-existence of osteoporosis and sarcopenia) and depression are highly prevalent among older people. However, the association between osteosarcopenia and depression in older people is largely unknown. Therefore, the present study aims to investigate this possible association in a representative sample of the older adult population in Europe and Israel. Methods: Osteosarcopenia was defined as the concomitant presence of osteoporosis and sarcopenia; depressive symptoms in the SHARE study were self-reported using the EURO-D scale. The association between the presence of osteosarcopenia at baseline in people free from depression and incident depression during 12 years of follow-up was analyzed using a Cox's regression analysis, adjusting for several baseline covariates. Results: 16,452 participants were included (mean age 63.7, SD 9.6; females 50.6 %). During the follow-up period, 5056 participants (31.1 % of the initial population) became depressed. People affected by osteosarcopenia became depressed in more than half of the cases compared to a quarter of controls. After adjusting for several potential baseline confounding variables, only sarcopenia (HR, hazard ratio = 1.17; 95 % CI, confidence intervals 1.04–1.32; p = 0.009) and osteosarcopenia (HR = 1.27; CI 95 % 1.12–1.58; p = 0.003) were significantly associated with a higher risk of depression. Limitations: Definition of sarcopenia using an anthropometric equation; definition of depression using the EURO-D scale. Conclusions: The present study identified a significant association between osteosarcopenia and depression over 12 years of follow-up, mainly driven by sarcopenia. If future research confirms the present findings, it may then be prudent to target those with osteosarcopenia to aid in the prevention of onset depression.http://www.sciencedirect.com/science/article/pii/S2352187225000257OsteosarcopeniaOsteoporosisSarcopeniaDepressionSHARE |
| spellingShingle | Nicola Veronese Francesco Saverio Ragusa Shaun Sabico Ligia Juliana Dominguez Mario Barbagallo Gustavo Duque Lee Smith Nasser Al-Daghri Osteosarcopenia as a risk factor for depression: Longitudinal findings from the SHARE study Bone Reports Osteosarcopenia Osteoporosis Sarcopenia Depression SHARE |
| title | Osteosarcopenia as a risk factor for depression: Longitudinal findings from the SHARE study |
| title_full | Osteosarcopenia as a risk factor for depression: Longitudinal findings from the SHARE study |
| title_fullStr | Osteosarcopenia as a risk factor for depression: Longitudinal findings from the SHARE study |
| title_full_unstemmed | Osteosarcopenia as a risk factor for depression: Longitudinal findings from the SHARE study |
| title_short | Osteosarcopenia as a risk factor for depression: Longitudinal findings from the SHARE study |
| title_sort | osteosarcopenia as a risk factor for depression longitudinal findings from the share study |
| topic | Osteosarcopenia Osteoporosis Sarcopenia Depression SHARE |
| url | http://www.sciencedirect.com/science/article/pii/S2352187225000257 |
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