Mechanisms of anesthetic-induced immune dysregulation
Abstract Anesthesia is essential in modern surgical practice, ensuring patient comfort, immobility, and amnesia. However, its impact on the immune system has become a growing area of research, as anesthetic agents can modulate immune function in complex ways. Emerging evidence suggests that anesthet...
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-08-01
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| Series: | Anesthesiology and Perioperative Science |
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| Online Access: | https://doi.org/10.1007/s44254-025-00117-2 |
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| author | Tatiane Renata Fagundes Carolina Coradi Marina Rayciki Sotomayor Aline Graciele Henriques Campos Luísa Cristina Fortuna da Silva Hellena Alves Ferneda Wilson da Silva Pereira Junior Gabriela Bonetti Bellandi Maria Eduarda Pardal Simonato Valentina Vieira Steffanello Larissa de Oliveira Manes Rafael Gomes Paz Edina Cassiane Padilha Felipe da Silva Bender Ricardo Nogueira Vincensi Maria Paula de Andrade Berny Mateus Lucas Falco Odirlei João Titon Carolina Panis |
| author_facet | Tatiane Renata Fagundes Carolina Coradi Marina Rayciki Sotomayor Aline Graciele Henriques Campos Luísa Cristina Fortuna da Silva Hellena Alves Ferneda Wilson da Silva Pereira Junior Gabriela Bonetti Bellandi Maria Eduarda Pardal Simonato Valentina Vieira Steffanello Larissa de Oliveira Manes Rafael Gomes Paz Edina Cassiane Padilha Felipe da Silva Bender Ricardo Nogueira Vincensi Maria Paula de Andrade Berny Mateus Lucas Falco Odirlei João Titon Carolina Panis |
| author_sort | Tatiane Renata Fagundes |
| collection | DOAJ |
| description | Abstract Anesthesia is essential in modern surgical practice, ensuring patient comfort, immobility, and amnesia. However, its impact on the immune system has become a growing area of research, as anesthetic agents can modulate immune function in complex ways. Emerging evidence suggests that anesthetics may induce immune dysregulation, affecting both innate and adaptive immunity, with potential consequences for patient outcomes, particularly in the context of infection, inflammation and cancer. This review provides a comprehensive understanding of the immunological effects of anesthesia, exploring the molecular and cellular pathways involved. It examines how anesthetics can either suppress or modulate immune responses, depending on factors including drug type, dose and patient-specific characteristics. We discuss their influence on innate immunity, including the activity of natural killer cells, macrophages and neutrophils, as well as their impact on adaptive immunity, particularly T-cell activation, cytokine production and antigen presentation. In addition, we highlight the immunological consequences of commonly used anesthetic agents in clinical practice. |
| format | Article |
| id | doaj-art-366907bde9334da6b1a2a539693bc8d2 |
| institution | Kabale University |
| issn | 2731-8389 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Springer |
| record_format | Article |
| series | Anesthesiology and Perioperative Science |
| spelling | doaj-art-366907bde9334da6b1a2a539693bc8d22025-08-20T03:42:37ZengSpringerAnesthesiology and Perioperative Science2731-83892025-08-013311710.1007/s44254-025-00117-2Mechanisms of anesthetic-induced immune dysregulationTatiane Renata Fagundes0Carolina Coradi1Marina Rayciki Sotomayor2Aline Graciele Henriques Campos3Luísa Cristina Fortuna da Silva4Hellena Alves Ferneda5Wilson da Silva Pereira Junior6Gabriela Bonetti Bellandi7Maria Eduarda Pardal Simonato8Valentina Vieira Steffanello9Larissa de Oliveira Manes10Rafael Gomes Paz11Edina Cassiane Padilha12Felipe da Silva Bender13Ricardo Nogueira Vincensi14Maria Paula de Andrade Berny15Mateus Lucas Falco16Odirlei João Titon17Carolina Panis18State University of North ParanáLaboratory of Tumor Biology, Health Sciences Center, Francisco Beltrão Campus, State University of Western Paraná. Francisco BeltrãoLaboratory of Tumor Biology, Health Sciences Center, Francisco Beltrão Campus, State University of Western Paraná. Francisco BeltrãoLaboratory of Tumor Biology, Health Sciences Center, Francisco Beltrão Campus, State University of Western Paraná. Francisco BeltrãoLaboratory of Tumor Biology, Health Sciences Center, Francisco Beltrão Campus, State University of Western Paraná. Francisco BeltrãoLaboratory of Tumor Biology, Health Sciences Center, Francisco Beltrão Campus, State University of Western Paraná. Francisco BeltrãoLaboratory of Tumor Biology, Health Sciences Center, Francisco Beltrão Campus, State University of Western Paraná. Francisco BeltrãoLaboratory of Tumor Biology, Health Sciences Center, Francisco Beltrão Campus, State University of Western Paraná. Francisco BeltrãoLaboratory of Tumor Biology, Health Sciences Center, Francisco Beltrão Campus, State University of Western Paraná. Francisco BeltrãoLaboratory of Tumor Biology, Health Sciences Center, Francisco Beltrão Campus, State University of Western Paraná. Francisco BeltrãoLaboratory of Tumor Biology, Health Sciences Center, Francisco Beltrão Campus, State University of Western Paraná. Francisco BeltrãoLaboratory of Tumor Biology, Health Sciences Center, Francisco Beltrão Campus, State University of Western Paraná. Francisco BeltrãoLaboratory of Tumor Biology, Health Sciences Center, Francisco Beltrão Campus, State University of Western Paraná. Francisco BeltrãoLaboratory of Tumor Biology, Health Sciences Center, Francisco Beltrão Campus, State University of Western Paraná. Francisco BeltrãoLaboratory of Tumor Biology, Health Sciences Center, Francisco Beltrão Campus, State University of Western Paraná. Francisco BeltrãoLaboratory of Tumor Biology, Health Sciences Center, Francisco Beltrão Campus, State University of Western Paraná. Francisco BeltrãoIPEC Genomic Research InstituteLaboratory of Tumor Biology, Health Sciences Center, Francisco Beltrão Campus, State University of Western Paraná. Francisco BeltrãoLaboratory of Tumor Biology, Health Sciences Center, Francisco Beltrão Campus, State University of Western Paraná. Francisco BeltrãoAbstract Anesthesia is essential in modern surgical practice, ensuring patient comfort, immobility, and amnesia. However, its impact on the immune system has become a growing area of research, as anesthetic agents can modulate immune function in complex ways. Emerging evidence suggests that anesthetics may induce immune dysregulation, affecting both innate and adaptive immunity, with potential consequences for patient outcomes, particularly in the context of infection, inflammation and cancer. This review provides a comprehensive understanding of the immunological effects of anesthesia, exploring the molecular and cellular pathways involved. It examines how anesthetics can either suppress or modulate immune responses, depending on factors including drug type, dose and patient-specific characteristics. We discuss their influence on innate immunity, including the activity of natural killer cells, macrophages and neutrophils, as well as their impact on adaptive immunity, particularly T-cell activation, cytokine production and antigen presentation. In addition, we highlight the immunological consequences of commonly used anesthetic agents in clinical practice.https://doi.org/10.1007/s44254-025-00117-2AnesthesiaAnesthetic drugsImmune responseImmune dysregulation |
| spellingShingle | Tatiane Renata Fagundes Carolina Coradi Marina Rayciki Sotomayor Aline Graciele Henriques Campos Luísa Cristina Fortuna da Silva Hellena Alves Ferneda Wilson da Silva Pereira Junior Gabriela Bonetti Bellandi Maria Eduarda Pardal Simonato Valentina Vieira Steffanello Larissa de Oliveira Manes Rafael Gomes Paz Edina Cassiane Padilha Felipe da Silva Bender Ricardo Nogueira Vincensi Maria Paula de Andrade Berny Mateus Lucas Falco Odirlei João Titon Carolina Panis Mechanisms of anesthetic-induced immune dysregulation Anesthesiology and Perioperative Science Anesthesia Anesthetic drugs Immune response Immune dysregulation |
| title | Mechanisms of anesthetic-induced immune dysregulation |
| title_full | Mechanisms of anesthetic-induced immune dysregulation |
| title_fullStr | Mechanisms of anesthetic-induced immune dysregulation |
| title_full_unstemmed | Mechanisms of anesthetic-induced immune dysregulation |
| title_short | Mechanisms of anesthetic-induced immune dysregulation |
| title_sort | mechanisms of anesthetic induced immune dysregulation |
| topic | Anesthesia Anesthetic drugs Immune response Immune dysregulation |
| url | https://doi.org/10.1007/s44254-025-00117-2 |
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