Epidemiology of chronic and acute pancreatitis in India (EPICAP-India): protocol for a multicentre study
Introduction Acute and chronic pancreatitis (CP) are inflammatory conditions of the pancreas that cause local and systemic complications. The epidemiology of these conditions are not well-known in India.Methods and analysis We describe the protocol and procedures of a multicentre study for delineati...
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2024-12-01
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| Series: | BMJ Open Gastroenterology |
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| author | Sanjeev Kumar Saransh Jain Vineet Ahuja Rakesh Kumar Anand Krishnan Pankaj Bhardwaj Shalimar Nitya Wadhwa Ashish Agarwal Deepak Gunjan Sudipta Dhar Chowdhury Anoop Saraya Saurabh Kedia Govind K Makharia Pramod Kumar Garg Ritvik Amarchand Deepti Dabar Rajib Sarkar Gopal Krishna Dhali Anmol Gupta Shivendra Singh Divya Pillai Vineeta Baloni Subhra Samujjwal Basu Bikash Choudhury Soumi Das Pradeep Deshmukh Krishnadas Devadas Nitika Monga Sumit Rungta Brij Sharma Chintha Sujatha |
| author_facet | Sanjeev Kumar Saransh Jain Vineet Ahuja Rakesh Kumar Anand Krishnan Pankaj Bhardwaj Shalimar Nitya Wadhwa Ashish Agarwal Deepak Gunjan Sudipta Dhar Chowdhury Anoop Saraya Saurabh Kedia Govind K Makharia Pramod Kumar Garg Ritvik Amarchand Deepti Dabar Rajib Sarkar Gopal Krishna Dhali Anmol Gupta Shivendra Singh Divya Pillai Vineeta Baloni Subhra Samujjwal Basu Bikash Choudhury Soumi Das Pradeep Deshmukh Krishnadas Devadas Nitika Monga Sumit Rungta Brij Sharma Chintha Sujatha |
| author_sort | Sanjeev Kumar |
| collection | DOAJ |
| description | Introduction Acute and chronic pancreatitis (CP) are inflammatory conditions of the pancreas that cause local and systemic complications. The epidemiology of these conditions are not well-known in India.Methods and analysis We describe the protocol and procedures of a multicentre study for delineating the epidemiology of pancreatitis in India. We plan to cover 110 000 people across 10 geographically distributed sites in 10 states of India to estimate the burden and risk factors of CP. Trained investigators will make house visits and screen for abdominal pain requiring hospitalisation or pre-diagnosed CP. The screened positive participants will be reviewed by a gastroenterologist to confirm the diagnosis of CP based on radiological imaging. For each case, four controls will be selected and data on risk factors for CP (tobacco, alcohol, family history, metabolic causes) and blood for genetic markers will be collected. Information on the cost of treatment and quality of life will be collected from patients with CP. For estimating incidence of acute pancreatitis (AP), hospital-based sentinel surveillance will be conducted in 10 districts across these 10 states. All hospitals in the district will be contacted to provide a line list of admissions due to acute abdomen including AP for 2 years. The spread of acute abdomen cases will be used to define the catchment area and estimate the denominator population. The line-listed cases with AP living in the catchment area will form the numerator to calculate the incidence. The study will provide critical information for planning pancreatitis-related services in the country.Ethics and dissemination The institutional ethics committee (IECs) at all the participating sites have given their approval for the study. All the participants whose data will be collected will be included after written informed consent. The results may be presented at national or international conferences and will be reported in peer-reviewed publications. |
| format | Article |
| id | doaj-art-3668e95d1ff8420a88b488aee0883077 |
| institution | Kabale University |
| issn | 2054-4774 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Gastroenterology |
| spelling | doaj-art-3668e95d1ff8420a88b488aee08830772025-01-06T18:40:08ZengBMJ Publishing GroupBMJ Open Gastroenterology2054-47742024-12-0111110.1136/bmjgast-2024-001562Epidemiology of chronic and acute pancreatitis in India (EPICAP-India): protocol for a multicentre studySanjeev Kumar0Saransh Jain1Vineet Ahuja2Rakesh Kumar3Anand Krishnan4Pankaj Bhardwaj5 Shalimar6Nitya Wadhwa7Ashish Agarwal8Deepak Gunjan9Sudipta Dhar Chowdhury10Anoop Saraya11Saurabh Kedia12Govind K Makharia13Pramod Kumar Garg14Ritvik Amarchand15Deepti Dabar16Rajib Sarkar17Gopal Krishna Dhali18Anmol Gupta19Shivendra Singh20Divya Pillai21Vineeta Baloni22Subhra Samujjwal Basu23Bikash Choudhury24Soumi Das25Pradeep Deshmukh26Krishnadas Devadas27Nitika Monga28Sumit Rungta29Brij Sharma30Chintha Sujatha31All India Institute of Medical Science Bhopal, Bhopal, Madhya Pradesh, IndiaConsultant Gastroenterologist, Jainamshree multi-speciality hospital, Bhopal, Madhya Pradesh, IndiaAll India Institute of Medical Sciences New Delhi, New Delhi, IndiaAll India Institute of Medical Sciences New Delhi, New Delhi, IndiaAll India Institute of Medical Sciences New Delhi, New Delhi, IndiaAll India Institute of Medical Sciences, Jodhpur, Rajasthan, IndiaAll India Institute of Medical Sciences New Delhi, New Delhi, IndiaTranslational Health Science and Technology Institute, Faridababd, Haryana, IndiaAll India Institute of Medical Sciences, Jodhpur, Rajasthan, IndiaAll India Institute of Medical Sciences New Delhi, New Delhi, IndiaChristian Medical College and Hospital Vellore, Vellore, Tamil Nadu, IndiaAll India Institute of Medical Sciences New Delhi, New Delhi, IndiaAll India Institute of Medical Sciences New Delhi, New Delhi, IndiaAll India Institute of Medical Sciences New Delhi, New Delhi, IndiaAll India Institute of Medical Sciences New Delhi, New Delhi, IndiaAll India Institute of Medical Sciences New Delhi, New Delhi, IndiaAll India Institute of Medical Science Bhopal, Bhopal, Madhya Pradesh, IndiaInstitute of Postgraduate Medical Education and Research, Kolkata, West Bengal, IndiaInstitute of Postgraduate Medical Education and Research, Kolkata, West Bengal, IndiaIndira Gandhi Medical College and Hospital, Shimla, Himachal Pradesh, IndiaKing George Medical College, Lucknow, Uttar Pradesh, IndiaTranslational Health Science and Technology Institute, Faridababd, Haryana, IndiaTranslational Health Science and Technology Institute, Faridababd, Haryana, IndiaInstitute of Postgraduate Medical Education and Research, Kolkata, West Bengal, IndiaGuwahati Medical College, Guwahati, Assam, IndiaIndian Council of Medical Research, New Delhi, Delhi, IndiaAll India Institute of Medical Sciences - Nagpur, Nagpur, Maharashtra, IndiaGovernment Medical College Thiruvananthapuram, Thiruvananthapuram, Kerala, IndiaIndian Council of Medical Research, New Delhi, Delhi, IndiaKing George Medical College, Lucknow, Uttar Pradesh, IndiaIndira Gandhi Medical College and Hospital, Shimla, Himachal Pradesh, IndiaGovernment Medical College Thiruvananthapuram, Thiruvananthapuram, Kerala, IndiaIntroduction Acute and chronic pancreatitis (CP) are inflammatory conditions of the pancreas that cause local and systemic complications. The epidemiology of these conditions are not well-known in India.Methods and analysis We describe the protocol and procedures of a multicentre study for delineating the epidemiology of pancreatitis in India. We plan to cover 110 000 people across 10 geographically distributed sites in 10 states of India to estimate the burden and risk factors of CP. Trained investigators will make house visits and screen for abdominal pain requiring hospitalisation or pre-diagnosed CP. The screened positive participants will be reviewed by a gastroenterologist to confirm the diagnosis of CP based on radiological imaging. For each case, four controls will be selected and data on risk factors for CP (tobacco, alcohol, family history, metabolic causes) and blood for genetic markers will be collected. Information on the cost of treatment and quality of life will be collected from patients with CP. For estimating incidence of acute pancreatitis (AP), hospital-based sentinel surveillance will be conducted in 10 districts across these 10 states. All hospitals in the district will be contacted to provide a line list of admissions due to acute abdomen including AP for 2 years. The spread of acute abdomen cases will be used to define the catchment area and estimate the denominator population. The line-listed cases with AP living in the catchment area will form the numerator to calculate the incidence. The study will provide critical information for planning pancreatitis-related services in the country.Ethics and dissemination The institutional ethics committee (IECs) at all the participating sites have given their approval for the study. All the participants whose data will be collected will be included after written informed consent. The results may be presented at national or international conferences and will be reported in peer-reviewed publications.https://bmjopengastro.bmj.com/content/11/1/e001562.full |
| spellingShingle | Sanjeev Kumar Saransh Jain Vineet Ahuja Rakesh Kumar Anand Krishnan Pankaj Bhardwaj Shalimar Nitya Wadhwa Ashish Agarwal Deepak Gunjan Sudipta Dhar Chowdhury Anoop Saraya Saurabh Kedia Govind K Makharia Pramod Kumar Garg Ritvik Amarchand Deepti Dabar Rajib Sarkar Gopal Krishna Dhali Anmol Gupta Shivendra Singh Divya Pillai Vineeta Baloni Subhra Samujjwal Basu Bikash Choudhury Soumi Das Pradeep Deshmukh Krishnadas Devadas Nitika Monga Sumit Rungta Brij Sharma Chintha Sujatha Epidemiology of chronic and acute pancreatitis in India (EPICAP-India): protocol for a multicentre study BMJ Open Gastroenterology |
| title | Epidemiology of chronic and acute pancreatitis in India (EPICAP-India): protocol for a multicentre study |
| title_full | Epidemiology of chronic and acute pancreatitis in India (EPICAP-India): protocol for a multicentre study |
| title_fullStr | Epidemiology of chronic and acute pancreatitis in India (EPICAP-India): protocol for a multicentre study |
| title_full_unstemmed | Epidemiology of chronic and acute pancreatitis in India (EPICAP-India): protocol for a multicentre study |
| title_short | Epidemiology of chronic and acute pancreatitis in India (EPICAP-India): protocol for a multicentre study |
| title_sort | epidemiology of chronic and acute pancreatitis in india epicap india protocol for a multicentre study |
| url | https://bmjopengastro.bmj.com/content/11/1/e001562.full |
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