Antiviral Activity of Aqueous Extracts and Polysaccharide Fractions from Mycelium and Fruit Bodies of Higher Fungi
Sixty preparations of basidiomycetes ( Ganoderma, Lentinus, Pleurotus, Laetiporus, Polyporus, Inonotus, Flammulina, Grifola, Trametes) were investigated with respect to their toxicity for Vero cells and antiviral activity. The antiviral activity was estimated with the use of the West Nile virus and...
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2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/328 |
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| author | I. A. Razumov T. A. Kosogova E. I. Kazachinskaya L. I. Puchkova N. S. Shcherbakova I. A. Gorbunova I. N. Mikhailovskaya V. B. Loktev T. V. Teplyakova |
| author_facet | I. A. Razumov T. A. Kosogova E. I. Kazachinskaya L. I. Puchkova N. S. Shcherbakova I. A. Gorbunova I. N. Mikhailovskaya V. B. Loktev T. V. Teplyakova |
| author_sort | I. A. Razumov |
| collection | DOAJ |
| description | Sixty preparations of basidiomycetes ( Ganoderma, Lentinus, Pleurotus, Laetiporus, Polyporus, Inonotus, Flammulina, Grifola, Trametes) were investigated with respect to their toxicity for Vero cells and antiviral activity. The antiviral activity was estimated with the use of the West Nile virus and type 2 Herpes simplex. It was shown that 11 preparations of Ganoderma, Lentinus and Pleurotus completely inhibited the infective activity in doses not lower than 1000 TCD50 (the West Nile virus) and 100 PPU (type 2 Herpes simplex). The antiviral activity of the preparations was likely due to the content of polysaccharides or their derivatives in the composition. It increased with increasing of the quantity of the total polysaccharide fraction or its concentration. |
| format | Article |
| id | doaj-art-3665a74049ea48a0b83c2a18bfbde805 |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-3665a74049ea48a0b83c2a18bfbde8052025-08-20T03:59:08ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01559-101418327Antiviral Activity of Aqueous Extracts and Polysaccharide Fractions from Mycelium and Fruit Bodies of Higher FungiI. A. Razumov0T. A. Kosogova1E. I. Kazachinskaya2L. I. Puchkova3N. S. Shcherbakova4I. A. Gorbunova5I. N. Mikhailovskaya6V. B. Loktev7T. V. Teplyakova8State Scientific Centre of Virology and Biotechnology VEKTOR, Koltsovo, Novosibirsk RegionState Scientific Centre of Virology and Biotechnology VEKTOR, Koltsovo, Novosibirsk RegionState Scientific Centre of Virology and Biotechnology VEKTOR, Koltsovo, Novosibirsk RegionState Scientific Centre of Virology and Biotechnology VEKTOR, Koltsovo, Novosibirsk RegionState Scientific Centre of Virology and Biotechnology VEKTOR, Koltsovo, Novosibirsk RegionState Scientific Centre of Virology and Biotechnology VEKTOR, Koltsovo, Novosibirsk RegionState Scientific Centre of Virology and Biotechnology VEKTOR, Koltsovo, Novosibirsk RegionState Scientific Centre of Virology and Biotechnology VEKTOR, Koltsovo, Novosibirsk RegionState Scientific Centre of Virology and Biotechnology VEKTOR, Koltsovo, Novosibirsk RegionSixty preparations of basidiomycetes ( Ganoderma, Lentinus, Pleurotus, Laetiporus, Polyporus, Inonotus, Flammulina, Grifola, Trametes) were investigated with respect to their toxicity for Vero cells and antiviral activity. The antiviral activity was estimated with the use of the West Nile virus and type 2 Herpes simplex. It was shown that 11 preparations of Ganoderma, Lentinus and Pleurotus completely inhibited the infective activity in doses not lower than 1000 TCD50 (the West Nile virus) and 100 PPU (type 2 Herpes simplex). The antiviral activity of the preparations was likely due to the content of polysaccharides or their derivatives in the composition. It increased with increasing of the quantity of the total polysaccharide fraction or its concentration.https://www.antibiotics-chemotherapy.ru/jour/article/view/328higher fungimyceliumfruit bodiesaqueous extractspolysaccharine fractionsantiviral activitythe west nile virustype 2 herpes simplex |
| spellingShingle | I. A. Razumov T. A. Kosogova E. I. Kazachinskaya L. I. Puchkova N. S. Shcherbakova I. A. Gorbunova I. N. Mikhailovskaya V. B. Loktev T. V. Teplyakova Antiviral Activity of Aqueous Extracts and Polysaccharide Fractions from Mycelium and Fruit Bodies of Higher Fungi Антибиотики и Химиотерапия higher fungi mycelium fruit bodies aqueous extracts polysaccharine fractions antiviral activity the west nile virus type 2 herpes simplex |
| title | Antiviral Activity of Aqueous Extracts and Polysaccharide Fractions from Mycelium and Fruit Bodies of Higher Fungi |
| title_full | Antiviral Activity of Aqueous Extracts and Polysaccharide Fractions from Mycelium and Fruit Bodies of Higher Fungi |
| title_fullStr | Antiviral Activity of Aqueous Extracts and Polysaccharide Fractions from Mycelium and Fruit Bodies of Higher Fungi |
| title_full_unstemmed | Antiviral Activity of Aqueous Extracts and Polysaccharide Fractions from Mycelium and Fruit Bodies of Higher Fungi |
| title_short | Antiviral Activity of Aqueous Extracts and Polysaccharide Fractions from Mycelium and Fruit Bodies of Higher Fungi |
| title_sort | antiviral activity of aqueous extracts and polysaccharide fractions from mycelium and fruit bodies of higher fungi |
| topic | higher fungi mycelium fruit bodies aqueous extracts polysaccharine fractions antiviral activity the west nile virus type 2 herpes simplex |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/328 |
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