Clinical Spectrum and Outcome of Guillain-Barré Syndrome with Plasmapheresis
Context: Guillain-Barré syndrome (GBS) is an acute inflammatory neuropathy and has several electrophysiological subtypes and clinical variants. Treatment is mainly supportive and immunotherapy is given to shorten the disease course. Aims: The aim of this study was to define the outcome of GBS with p...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-10-01
|
| Series: | Indian Journal of Medical Specialities |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/injms.injms_50_22 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849224427306221568 |
|---|---|
| author | Safia Bano Zomer Sardar Muhammad Ahmar Sumayyah Liaquat Bilal Shafiq Ahsan Numan |
| author_facet | Safia Bano Zomer Sardar Muhammad Ahmar Sumayyah Liaquat Bilal Shafiq Ahsan Numan |
| author_sort | Safia Bano |
| collection | DOAJ |
| description | Context:
Guillain-Barré syndrome (GBS) is an acute inflammatory neuropathy and has several electrophysiological subtypes and clinical variants. Treatment is mainly supportive and immunotherapy is given to shorten the disease course.
Aims:
The aim of this study was to define the outcome of GBS with plasmapheresis and to determine its clinical spectrum.
Materials and Methods:
The prospective study was done at Mayo Hospital, Lahore, for 1 year from November 2020 to November 2021. The diagnosis of GBS was made on Brighton criteria for GBS. The outcome of therapy was assessed at 3 and 6 months, using the Medical Research Council Scale and Hughes Functional Grading Scale (HFGS).
Results:
A total of 50 patients were enrolled in the study. Twenty-seven (54%) were males and 23 (46%) were females. Seventeen (34%) had acute motor axonal neuropathy, 16 (32%) had acute motor and sensory axonal neuropathy, 15 (30%) had acute inflammatory demyelinating polyradiculoneuropathy, and 2 (4%) had Miller-Fisher syndrome. Plasmapheresis was done in all patients. HFGS score was assessed at discharge, at 3 months, and after 6 months of illness onset. The improvement in mean HFGS score was 2.79 ± 0.41 at 3 months and 1.94 ± 0.25 at 6 months of symptoms onset from the mean score of 3.46 ± 0.93 at the time of discharge from the hospital.
Conclusion:
Excellent outcome was observed after plasmapheresis. Majority of participants were able to walk without support at the 6-month follow-up. Plasmapheresis should be initiated early in the management of GBS where intravenous immunoglobulins are costly. |
| format | Article |
| id | doaj-art-366095c034e445a1849b333f916c1559 |
| institution | Kabale University |
| issn | 0976-2884 0976-2892 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Medical Specialities |
| spelling | doaj-art-366095c034e445a1849b333f916c15592025-08-25T08:38:34ZengWolters Kluwer Medknow PublicationsIndian Journal of Medical Specialities0976-28840976-28922022-10-0113422623010.4103/injms.injms_50_22Clinical Spectrum and Outcome of Guillain-Barré Syndrome with PlasmapheresisSafia BanoZomer SardarMuhammad AhmarSumayyah LiaquatBilal ShafiqAhsan NumanContext: Guillain-Barré syndrome (GBS) is an acute inflammatory neuropathy and has several electrophysiological subtypes and clinical variants. Treatment is mainly supportive and immunotherapy is given to shorten the disease course. Aims: The aim of this study was to define the outcome of GBS with plasmapheresis and to determine its clinical spectrum. Materials and Methods: The prospective study was done at Mayo Hospital, Lahore, for 1 year from November 2020 to November 2021. The diagnosis of GBS was made on Brighton criteria for GBS. The outcome of therapy was assessed at 3 and 6 months, using the Medical Research Council Scale and Hughes Functional Grading Scale (HFGS). Results: A total of 50 patients were enrolled in the study. Twenty-seven (54%) were males and 23 (46%) were females. Seventeen (34%) had acute motor axonal neuropathy, 16 (32%) had acute motor and sensory axonal neuropathy, 15 (30%) had acute inflammatory demyelinating polyradiculoneuropathy, and 2 (4%) had Miller-Fisher syndrome. Plasmapheresis was done in all patients. HFGS score was assessed at discharge, at 3 months, and after 6 months of illness onset. The improvement in mean HFGS score was 2.79 ± 0.41 at 3 months and 1.94 ± 0.25 at 6 months of symptoms onset from the mean score of 3.46 ± 0.93 at the time of discharge from the hospital. Conclusion: Excellent outcome was observed after plasmapheresis. Majority of participants were able to walk without support at the 6-month follow-up. Plasmapheresis should be initiated early in the management of GBS where intravenous immunoglobulins are costly.https://journals.lww.com/10.4103/injms.injms_50_22guillain-barré syndromehughes functional grading scaleintravenous immunoglobulinsoutcomeplasmapheresis |
| spellingShingle | Safia Bano Zomer Sardar Muhammad Ahmar Sumayyah Liaquat Bilal Shafiq Ahsan Numan Clinical Spectrum and Outcome of Guillain-Barré Syndrome with Plasmapheresis Indian Journal of Medical Specialities guillain-barré syndrome hughes functional grading scale intravenous immunoglobulins outcome plasmapheresis |
| title | Clinical Spectrum and Outcome of Guillain-Barré Syndrome with Plasmapheresis |
| title_full | Clinical Spectrum and Outcome of Guillain-Barré Syndrome with Plasmapheresis |
| title_fullStr | Clinical Spectrum and Outcome of Guillain-Barré Syndrome with Plasmapheresis |
| title_full_unstemmed | Clinical Spectrum and Outcome of Guillain-Barré Syndrome with Plasmapheresis |
| title_short | Clinical Spectrum and Outcome of Guillain-Barré Syndrome with Plasmapheresis |
| title_sort | clinical spectrum and outcome of guillain barre syndrome with plasmapheresis |
| topic | guillain-barré syndrome hughes functional grading scale intravenous immunoglobulins outcome plasmapheresis |
| url | https://journals.lww.com/10.4103/injms.injms_50_22 |
| work_keys_str_mv | AT safiabano clinicalspectrumandoutcomeofguillainbarresyndromewithplasmapheresis AT zomersardar clinicalspectrumandoutcomeofguillainbarresyndromewithplasmapheresis AT muhammadahmar clinicalspectrumandoutcomeofguillainbarresyndromewithplasmapheresis AT sumayyahliaquat clinicalspectrumandoutcomeofguillainbarresyndromewithplasmapheresis AT bilalshafiq clinicalspectrumandoutcomeofguillainbarresyndromewithplasmapheresis AT ahsannuman clinicalspectrumandoutcomeofguillainbarresyndromewithplasmapheresis |