Association between high-density lipoprotein cholesterol and 7-autoantibodies: a study on physical examination data from 2018 to 2023
BackgroundLimited research has explored the effect of high-density lipoprotein cholesterol (HDL-C) on lung cancer’s seven autoantibodies (7-AABs). This study investigated the association between serum HDL-C and 7-AABs among 5,574 Chinese adults aged ≥ 18 years from January 2018 to December 2023.Meth...
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Frontiers Media S.A.
2025-03-01
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| _version_ | 1849709120529104896 |
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| author | Yang Zhou Yongbing Sun Qi Qiao Xin Qi Xinbei Lin Yawei Du Ao Liu Jing Zhou Xue Lv Zhonglin Li Xiaoling Wu Zhi Zou Michael Zhang Jiadong Zhu Feifei Shang Hao Li Yongli Li |
| author_facet | Yang Zhou Yongbing Sun Qi Qiao Xin Qi Xinbei Lin Yawei Du Ao Liu Jing Zhou Xue Lv Zhonglin Li Xiaoling Wu Zhi Zou Michael Zhang Jiadong Zhu Feifei Shang Hao Li Yongli Li |
| author_sort | Yang Zhou |
| collection | DOAJ |
| description | BackgroundLimited research has explored the effect of high-density lipoprotein cholesterol (HDL-C) on lung cancer’s seven autoantibodies (7-AABs). This study investigated the association between serum HDL-C and 7-AABs among 5,574 Chinese adults aged ≥ 18 years from January 2018 to December 2023.MethodsThis cross-sectional study utilized physical examination data from the Department of Health Management at Henan Provincial People’s Hospital. The associations between HDL-C and autoantibodies, such as tumor protein 53(P53), SRY-box containing gene 2 (SOX2), and ATP-dependent RNA helicase 4-5 (GBU4-5), were modeled using a restricted cubic spline logistic regression model.ResultsAfter the adjustment for factors, such as age and body mass index, the binary logistic regression model showed distinct correlations between serum HDL-C levels and autoantibodies, including P53, SOX2, and 7-AABs. Restricted cubic spline logistic regression analysis indicated that the increased level of serum HDL-C was associated with a decreased risk of positive P53 (all participants: HDL-C: 1.227–1.366 mmol/L, PHDL-C=0.028), SOX2 (all participants: HDL-C ≥ 1.227 mmol/L, PHDL-C =0.021; all women: HDL-C ≥ 1.224 mmol/L, PHDL-C=0.037), GBU4-5 (all women: HDL-C ≥ 1.269 mmol/L, PHDL-C=0.039), and 7-AABs (all women: HDL-C ≥ 1.224 mmol/L, PHDL-C=0.015). In women, HDL-C levels between 1.163 and 1.224 mmol/L correlated with an increased risk of positive 7-AABs test results.ConclusionsElevated HDL-C levels exhibited an independent association with a reduced risk of positivity for 7-AABs of lung cancer, especially in the female physical examination population. These findings suggest that high HDL-C levels may play a role in hindering lung cancer development with gender differences. However, further confirmation is still needed in the future. |
| format | Article |
| id | doaj-art-365a49fd13dd40ff920dd55c138d39ee |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-365a49fd13dd40ff920dd55c138d39ee2025-08-20T03:15:26ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-03-011610.3389/fendo.2025.15042661504266Association between high-density lipoprotein cholesterol and 7-autoantibodies: a study on physical examination data from 2018 to 2023Yang Zhou0Yongbing Sun1Qi Qiao2Xin Qi3Xinbei Lin4Yawei Du5Ao Liu6Jing Zhou7Xue Lv8Zhonglin Li9Xiaoling Wu10Zhi Zou11Michael Zhang12Jiadong Zhu13Feifei Shang14Hao Li15Yongli Li16Department of Medical Imaging, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Medical Imaging, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Medical Imaging, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Medical Imaging, Henan Provincial People’s Hospital, Xinxiang Medical University, Zhengzhou, Henan, ChinaDepartment of Medical Imaging, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Medical Imaging, Henan University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Medical Imaging, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, Henan, ChinaHenan Provincial Research Center of Clinical Medicine of Nephropathy, Zhengzhou University People’s Hospital, Henan University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Health Management, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Medical Imaging, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Nuclear Medicine, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Medical Imaging, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, Henan, ChinaSevenoaks Health Management Center, Canada-Canada Institute of Health Engineering, University of Manitoba, Winnipeg, MB, CanadaChronic Health Management Laboratory, Department of Health Management, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaChronic Health Management Laboratory, Department of Health Management, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Health Management, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan, ChinaChronic Health Management Laboratory, Department of Health Management, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaBackgroundLimited research has explored the effect of high-density lipoprotein cholesterol (HDL-C) on lung cancer’s seven autoantibodies (7-AABs). This study investigated the association between serum HDL-C and 7-AABs among 5,574 Chinese adults aged ≥ 18 years from January 2018 to December 2023.MethodsThis cross-sectional study utilized physical examination data from the Department of Health Management at Henan Provincial People’s Hospital. The associations between HDL-C and autoantibodies, such as tumor protein 53(P53), SRY-box containing gene 2 (SOX2), and ATP-dependent RNA helicase 4-5 (GBU4-5), were modeled using a restricted cubic spline logistic regression model.ResultsAfter the adjustment for factors, such as age and body mass index, the binary logistic regression model showed distinct correlations between serum HDL-C levels and autoantibodies, including P53, SOX2, and 7-AABs. Restricted cubic spline logistic regression analysis indicated that the increased level of serum HDL-C was associated with a decreased risk of positive P53 (all participants: HDL-C: 1.227–1.366 mmol/L, PHDL-C=0.028), SOX2 (all participants: HDL-C ≥ 1.227 mmol/L, PHDL-C =0.021; all women: HDL-C ≥ 1.224 mmol/L, PHDL-C=0.037), GBU4-5 (all women: HDL-C ≥ 1.269 mmol/L, PHDL-C=0.039), and 7-AABs (all women: HDL-C ≥ 1.224 mmol/L, PHDL-C=0.015). In women, HDL-C levels between 1.163 and 1.224 mmol/L correlated with an increased risk of positive 7-AABs test results.ConclusionsElevated HDL-C levels exhibited an independent association with a reduced risk of positivity for 7-AABs of lung cancer, especially in the female physical examination population. These findings suggest that high HDL-C levels may play a role in hindering lung cancer development with gender differences. However, further confirmation is still needed in the future.https://www.frontiersin.org/articles/10.3389/fendo.2025.1504266/fullHDL-C7-AABslung cancerChinese adultsphysical examinations |
| spellingShingle | Yang Zhou Yongbing Sun Qi Qiao Xin Qi Xinbei Lin Yawei Du Ao Liu Jing Zhou Xue Lv Zhonglin Li Xiaoling Wu Zhi Zou Michael Zhang Jiadong Zhu Feifei Shang Hao Li Yongli Li Association between high-density lipoprotein cholesterol and 7-autoantibodies: a study on physical examination data from 2018 to 2023 Frontiers in Endocrinology HDL-C 7-AABs lung cancer Chinese adults physical examinations |
| title | Association between high-density lipoprotein cholesterol and 7-autoantibodies: a study on physical examination data from 2018 to 2023 |
| title_full | Association between high-density lipoprotein cholesterol and 7-autoantibodies: a study on physical examination data from 2018 to 2023 |
| title_fullStr | Association between high-density lipoprotein cholesterol and 7-autoantibodies: a study on physical examination data from 2018 to 2023 |
| title_full_unstemmed | Association between high-density lipoprotein cholesterol and 7-autoantibodies: a study on physical examination data from 2018 to 2023 |
| title_short | Association between high-density lipoprotein cholesterol and 7-autoantibodies: a study on physical examination data from 2018 to 2023 |
| title_sort | association between high density lipoprotein cholesterol and 7 autoantibodies a study on physical examination data from 2018 to 2023 |
| topic | HDL-C 7-AABs lung cancer Chinese adults physical examinations |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1504266/full |
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