Synthesis and Analysis of Ketoprofen 1,4-Sorbitan Ester
This study presents the synthesis and comprehensive characterization of ketoprofen 1,4-sorbitan ester, a novel compound with potential applications in drug delivery. The compound was synthesized through a two-step process involving the acid-catalyzed dehydration of <i>D</i>-Glucose to fo...
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2025-01-01
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| author | Pooreum Lim Jae Ho Shim |
| author_facet | Pooreum Lim Jae Ho Shim |
| author_sort | Pooreum Lim |
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| description | This study presents the synthesis and comprehensive characterization of ketoprofen 1,4-sorbitan ester, a novel compound with potential applications in drug delivery. The compound was synthesized through a two-step process involving the acid-catalyzed dehydration of <i>D</i>-Glucose to form 1,4-sorbitan, followed by esterification with ketoprofen. The structures of ketoprofen 1,4-sorbitan ester and the reference compound, ketoprofen methyl ester, were rigorously analyzed using a combination of advanced analytical techniques. High-resolution accurate mass liquid chromatography–mass spectrometry was used to determine the precise molecular mass and elemental composition of the synthesized compounds. <sup>1</sup>H and <sup>13</sup>C nuclear magnetic resonance spectroscopy provided detailed information on the molecular structure and atomic connectivity to identify the specific functional groups and confirm the formation of ester bonds. |
| format | Article |
| id | doaj-art-3657a8944a7f4656bc07376c870c511f |
| institution | Kabale University |
| issn | 1422-8599 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
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| spelling | doaj-art-3657a8944a7f4656bc07376c870c511f2025-08-20T03:43:37ZengMDPI AGMolbank1422-85992025-01-0120251M195410.3390/M1954Synthesis and Analysis of Ketoprofen 1,4-Sorbitan EsterPooreum Lim0Jae Ho Shim1Department of Anatomy, College of Medicine, Korea University, 73, Goryeodae-ro, Seongbuk-gu, Seoul 02481, Republic of KoreaDepartment of Anatomy, College of Medicine, Korea University, 73, Goryeodae-ro, Seongbuk-gu, Seoul 02481, Republic of KoreaThis study presents the synthesis and comprehensive characterization of ketoprofen 1,4-sorbitan ester, a novel compound with potential applications in drug delivery. The compound was synthesized through a two-step process involving the acid-catalyzed dehydration of <i>D</i>-Glucose to form 1,4-sorbitan, followed by esterification with ketoprofen. The structures of ketoprofen 1,4-sorbitan ester and the reference compound, ketoprofen methyl ester, were rigorously analyzed using a combination of advanced analytical techniques. High-resolution accurate mass liquid chromatography–mass spectrometry was used to determine the precise molecular mass and elemental composition of the synthesized compounds. <sup>1</sup>H and <sup>13</sup>C nuclear magnetic resonance spectroscopy provided detailed information on the molecular structure and atomic connectivity to identify the specific functional groups and confirm the formation of ester bonds.https://www.mdpi.com/1422-8599/2025/1/M1954ketoprofen<i>D</i>-glucoseesterification reactionorganocatalyst |
| spellingShingle | Pooreum Lim Jae Ho Shim Synthesis and Analysis of Ketoprofen 1,4-Sorbitan Ester Molbank ketoprofen <i>D</i>-glucose esterification reaction organocatalyst |
| title | Synthesis and Analysis of Ketoprofen 1,4-Sorbitan Ester |
| title_full | Synthesis and Analysis of Ketoprofen 1,4-Sorbitan Ester |
| title_fullStr | Synthesis and Analysis of Ketoprofen 1,4-Sorbitan Ester |
| title_full_unstemmed | Synthesis and Analysis of Ketoprofen 1,4-Sorbitan Ester |
| title_short | Synthesis and Analysis of Ketoprofen 1,4-Sorbitan Ester |
| title_sort | synthesis and analysis of ketoprofen 1 4 sorbitan ester |
| topic | ketoprofen <i>D</i>-glucose esterification reaction organocatalyst |
| url | https://www.mdpi.com/1422-8599/2025/1/M1954 |
| work_keys_str_mv | AT pooreumlim synthesisandanalysisofketoprofen14sorbitanester AT jaehoshim synthesisandanalysisofketoprofen14sorbitanester |