Synthesis and Analysis of Ketoprofen 1,4-Sorbitan Ester
This study presents the synthesis and comprehensive characterization of ketoprofen 1,4-sorbitan ester, a novel compound with potential applications in drug delivery. The compound was synthesized through a two-step process involving the acid-catalyzed dehydration of <i>D</i>-Glucose to fo...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Molbank |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-8599/2025/1/M1954 |
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| Summary: | This study presents the synthesis and comprehensive characterization of ketoprofen 1,4-sorbitan ester, a novel compound with potential applications in drug delivery. The compound was synthesized through a two-step process involving the acid-catalyzed dehydration of <i>D</i>-Glucose to form 1,4-sorbitan, followed by esterification with ketoprofen. The structures of ketoprofen 1,4-sorbitan ester and the reference compound, ketoprofen methyl ester, were rigorously analyzed using a combination of advanced analytical techniques. High-resolution accurate mass liquid chromatography–mass spectrometry was used to determine the precise molecular mass and elemental composition of the synthesized compounds. <sup>1</sup>H and <sup>13</sup>C nuclear magnetic resonance spectroscopy provided detailed information on the molecular structure and atomic connectivity to identify the specific functional groups and confirm the formation of ester bonds. |
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| ISSN: | 1422-8599 |