Intra-arterial alteplase for acute ischaemic stroke after mechanical thrombectomy (PEARL): rationale and design of a multicentre, prospective, open-label, blinded-endpoint, randomised controlled trial

Intra-arterial alteplase for acute ischaemic stroke after mechanical thrombectomy (PEARL): rationale and design of a multicentre, prospective, open-label, blinded-endpoint, randomised controlled trial

Introduction Successful reperfusion does not always lead to good neurological outcomes and impaired microcirculation can be one of the underlying causes. Intra-arterial alteplase after mechanical thrombectomy (MT) may improve microcirculation contributing to neurological recovery, but prospective ra...

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Main Authors: Jie Li, Yajie Liu, Min Zhang, Haoyang Sun, Yingying Zhu, XinGuang Yang, Dong Pan, Yamei Tang, Hongbiao Hou, Xiongjun He, Yongteng Xu, Huiyuan Peng, Kaifeng Li, Yanting Chen, Baixuan He, Hongxing Zhou
Format: Article
Language:English
Published: BMJ Publishing Group 2024-11-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/14/11/e091059.full
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