Vitreous Analysis in the Management of Uveitis
A correct diagnosis of uveitis is often challenging, given the wide range of possible underlying conditions and the lack of typical phenotypes. Management decisions may be difficult in view of the risk of visual loss with either inappropriate or delayed therapy. Analysis of the vitreous may therefor...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/863418 |
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| _version_ | 1832549923555377152 |
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| author | Erika M. Damato Martina Angi Mario R. Romano Francesco Semeraro Ciro Costagliola |
| author_facet | Erika M. Damato Martina Angi Mario R. Romano Francesco Semeraro Ciro Costagliola |
| author_sort | Erika M. Damato |
| collection | DOAJ |
| description | A correct diagnosis of uveitis is often challenging, given the wide range of possible underlying conditions and the lack of typical phenotypes. Management decisions may be difficult in view of the risk of visual loss with either inappropriate or delayed therapy. Analysis of the vitreous may therefore be used to provide the clinician with valuable information. In this paper, we describe the main clinical situations in which vitreous sampling is indicated and provide some guidance to clinicians for tailoring their requests. These situations include suspected intraocular infection and suspected intraocular malignancy. We describe the principal tests carried out on vitreous samples, including cultures, polymerase chain reaction-based testing, and cytokine analysis. Limitations of the tests used are likely to become less as more advanced testing methods are introduced. The importance of selecting the appropriate investigations to support a clinical suspicion is emphasised, as is the interpretation of test results within a clinical context. |
| format | Article |
| id | doaj-art-36503447a9564677ba1f3489e8d9f228 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-36503447a9564677ba1f3489e8d9f2282025-02-03T06:08:13ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/863418863418Vitreous Analysis in the Management of UveitisErika M. Damato0Martina Angi1Mario R. Romano2Francesco Semeraro3Ciro Costagliola4Regional Ocular Inflammatory Service, Bristol Eye Hospital, Bristol BS1 2LX, UKDepartment of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3BX, UKDepartment of Ophthalmology, Istituto Clinico Humanitas, Milan, ItalyDepartment of Ophthalmology, Spedali Civili di Brscia, University of Brescia, Brescia, ItalyDepartment of Health Sciences, University of Molise, Campobasso, ItalyA correct diagnosis of uveitis is often challenging, given the wide range of possible underlying conditions and the lack of typical phenotypes. Management decisions may be difficult in view of the risk of visual loss with either inappropriate or delayed therapy. Analysis of the vitreous may therefore be used to provide the clinician with valuable information. In this paper, we describe the main clinical situations in which vitreous sampling is indicated and provide some guidance to clinicians for tailoring their requests. These situations include suspected intraocular infection and suspected intraocular malignancy. We describe the principal tests carried out on vitreous samples, including cultures, polymerase chain reaction-based testing, and cytokine analysis. Limitations of the tests used are likely to become less as more advanced testing methods are introduced. The importance of selecting the appropriate investigations to support a clinical suspicion is emphasised, as is the interpretation of test results within a clinical context.http://dx.doi.org/10.1155/2012/863418 |
| spellingShingle | Erika M. Damato Martina Angi Mario R. Romano Francesco Semeraro Ciro Costagliola Vitreous Analysis in the Management of Uveitis Mediators of Inflammation |
| title | Vitreous Analysis in the Management of Uveitis |
| title_full | Vitreous Analysis in the Management of Uveitis |
| title_fullStr | Vitreous Analysis in the Management of Uveitis |
| title_full_unstemmed | Vitreous Analysis in the Management of Uveitis |
| title_short | Vitreous Analysis in the Management of Uveitis |
| title_sort | vitreous analysis in the management of uveitis |
| url | http://dx.doi.org/10.1155/2012/863418 |
| work_keys_str_mv | AT erikamdamato vitreousanalysisinthemanagementofuveitis AT martinaangi vitreousanalysisinthemanagementofuveitis AT mariorromano vitreousanalysisinthemanagementofuveitis AT francescosemeraro vitreousanalysisinthemanagementofuveitis AT cirocostagliola vitreousanalysisinthemanagementofuveitis |