Circular RNAs perspective: exploring the direction of immunotherapy for colorectal cancer
Circular RNAs (circRNAs) are multifaceted molecules that play a pivotal role in regulating gene expression at both transcriptional and post-transcriptional levels. Their expression is highly tissue-specific and developmentally regulated, making them critical players in various physiological processe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1554179/full |
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| author | Yanlin Cao Yanlin Cao Yuxing He Lingshan Liao Lixin Xu |
| author_facet | Yanlin Cao Yanlin Cao Yuxing He Lingshan Liao Lixin Xu |
| author_sort | Yanlin Cao |
| collection | DOAJ |
| description | Circular RNAs (circRNAs) are multifaceted molecules that play a pivotal role in regulating gene expression at both transcriptional and post-transcriptional levels. Their expression is highly tissue-specific and developmentally regulated, making them critical players in various physiological processes and diseases, particularly cancer. In colorectal cancer, circRNAs exhibit significantly dysregulated expression patterns and profoundly influence disease progression through diverse molecular mechanisms. Unraveling the complex roles of circRNAs in modulating colorectal cancer immunotherapy outcomes highlights their potential as both promising biomarkers and therapeutic targets. Moving forward, advancements in circRNA-based therapeutic strategies and delivery systems are poised to transform precision medicine, enabling early colorectal cancer diagnosis and improving patient prognosis. |
| format | Article |
| id | doaj-art-364ff521595240898b7ba35fc2d26a41 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-364ff521595240898b7ba35fc2d26a412025-08-20T03:09:09ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-04-011510.3389/fonc.2025.15541791554179Circular RNAs perspective: exploring the direction of immunotherapy for colorectal cancerYanlin Cao0Yanlin Cao1Yuxing He2Lingshan Liao3Lixin Xu4Department of Pathology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, ChinaThe First Clinical Medical College of Guangdong Medical University, Zhanjiang, ChinaDepartment of Medical Laboratory Medicine, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, ChinaDepartment of Pathology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, ChinaNeurosurgery Department, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, ChinaCircular RNAs (circRNAs) are multifaceted molecules that play a pivotal role in regulating gene expression at both transcriptional and post-transcriptional levels. Their expression is highly tissue-specific and developmentally regulated, making them critical players in various physiological processes and diseases, particularly cancer. In colorectal cancer, circRNAs exhibit significantly dysregulated expression patterns and profoundly influence disease progression through diverse molecular mechanisms. Unraveling the complex roles of circRNAs in modulating colorectal cancer immunotherapy outcomes highlights their potential as both promising biomarkers and therapeutic targets. Moving forward, advancements in circRNA-based therapeutic strategies and delivery systems are poised to transform precision medicine, enabling early colorectal cancer diagnosis and improving patient prognosis.https://www.frontiersin.org/articles/10.3389/fonc.2025.1554179/fullcircular RNAcolorectal cancerimmunotherapydiagnosisprecision medicine |
| spellingShingle | Yanlin Cao Yanlin Cao Yuxing He Lingshan Liao Lixin Xu Circular RNAs perspective: exploring the direction of immunotherapy for colorectal cancer Frontiers in Oncology circular RNA colorectal cancer immunotherapy diagnosis precision medicine |
| title | Circular RNAs perspective: exploring the direction of immunotherapy for colorectal cancer |
| title_full | Circular RNAs perspective: exploring the direction of immunotherapy for colorectal cancer |
| title_fullStr | Circular RNAs perspective: exploring the direction of immunotherapy for colorectal cancer |
| title_full_unstemmed | Circular RNAs perspective: exploring the direction of immunotherapy for colorectal cancer |
| title_short | Circular RNAs perspective: exploring the direction of immunotherapy for colorectal cancer |
| title_sort | circular rnas perspective exploring the direction of immunotherapy for colorectal cancer |
| topic | circular RNA colorectal cancer immunotherapy diagnosis precision medicine |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1554179/full |
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