Ökonomische Herstellung von Feinchemikalien: Tetronsäure
Tetronic acid (1) is synthesized from ethyl 2,4-dichloroacetoacetate (11) via 3-chlorotetronic acid (9). Ring closure of 11 to 9 is achieved by pyrolysis at normal pressure. In contrast to the bromo-derivative 8, the catalytic conversion of 9 to 1 takes place in water in the absence of base. In thi...
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
1987-03-01
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| Series: | CHIMIA |
| Online Access: | https://www.chimia.ch/chimia/article/view/9777 |
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| _version_ | 1850170713439207424 |
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| author | Thomas Meul Raimund Miller Leander Tenud |
| author_facet | Thomas Meul Raimund Miller Leander Tenud |
| author_sort | Thomas Meul |
| collection | DOAJ |
| description |
Tetronic acid (1) is synthesized from ethyl 2,4-dichloroacetoacetate (11) via 3-chlorotetronic acid (9). Ring closure of 11 to 9 is achieved by pyrolysis at normal pressure. In contrast to the bromo-derivative 8, the catalytic conversion of 9 to 1 takes place in water in the absence of base. In this way the large-scale separation of 1 from salts is avoided. The described process affords a high-quality product in an overall yield of 75%.
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| format | Article |
| id | doaj-art-364e1facc2c94f35b06a7a218caaa06e |
| institution | OA Journals |
| issn | 0009-4293 2673-2424 |
| language | deu |
| publishDate | 1987-03-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj-art-364e1facc2c94f35b06a7a218caaa06e2025-08-20T02:20:26ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24241987-03-0141310.2533/chimia.1987.73Ökonomische Herstellung von Feinchemikalien: TetronsäureThomas Meul0Raimund Miller1Leander Tenud2Forschungsabteilung der Sparte Organische Chemie, Lonza AG, CH-3930 VispForschungsabteilung der Sparte Organische Chemie, Lonza AG, CH-3930 VispForschungsabteilung der Sparte Organische Chemie, Lonza AG, CH-3930 Visp Tetronic acid (1) is synthesized from ethyl 2,4-dichloroacetoacetate (11) via 3-chlorotetronic acid (9). Ring closure of 11 to 9 is achieved by pyrolysis at normal pressure. In contrast to the bromo-derivative 8, the catalytic conversion of 9 to 1 takes place in water in the absence of base. In this way the large-scale separation of 1 from salts is avoided. The described process affords a high-quality product in an overall yield of 75%. https://www.chimia.ch/chimia/article/view/9777 |
| spellingShingle | Thomas Meul Raimund Miller Leander Tenud Ökonomische Herstellung von Feinchemikalien: Tetronsäure CHIMIA |
| title | Ökonomische Herstellung von Feinchemikalien: Tetronsäure |
| title_full | Ökonomische Herstellung von Feinchemikalien: Tetronsäure |
| title_fullStr | Ökonomische Herstellung von Feinchemikalien: Tetronsäure |
| title_full_unstemmed | Ökonomische Herstellung von Feinchemikalien: Tetronsäure |
| title_short | Ökonomische Herstellung von Feinchemikalien: Tetronsäure |
| title_sort | okonomische herstellung von feinchemikalien tetronsaure |
| url | https://www.chimia.ch/chimia/article/view/9777 |
| work_keys_str_mv | AT thomasmeul okonomischeherstellungvonfeinchemikalientetronsaure AT raimundmiller okonomischeherstellungvonfeinchemikalientetronsaure AT leandertenud okonomischeherstellungvonfeinchemikalientetronsaure |