Ökonomische Herstellung von Feinchemikalien: Tetronsäure
Tetronic acid (1) is synthesized from ethyl 2,4-dichloroacetoacetate (11) via 3-chlorotetronic acid (9). Ring closure of 11 to 9 is achieved by pyrolysis at normal pressure. In contrast to the bromo-derivative 8, the catalytic conversion of 9 to 1 takes place in water in the absence of base. In thi...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
1987-03-01
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| Series: | CHIMIA |
| Online Access: | https://www.chimia.ch/chimia/article/view/9777 |
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| Summary: | Tetronic acid (1) is synthesized from ethyl 2,4-dichloroacetoacetate (11) via 3-chlorotetronic acid (9). Ring closure of 11 to 9 is achieved by pyrolysis at normal pressure. In contrast to the bromo-derivative 8, the catalytic conversion of 9 to 1 takes place in water in the absence of base. In this way the large-scale separation of 1 from salts is avoided. The described process affords a high-quality product in an overall yield of 75%.
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| ISSN: | 0009-4293 2673-2424 |