Ameliorative Protective Influence of Etoricoxib Against Chemo Convulsions Correlates with Blood Glucose Levels in Rats
Objective: The effect of Etoricoxib (ETOR) on the link between blood glucose and seizure prevention in chemo-convulsive rats was investigated in this study. Methods: Pentylenetetrazol (PTZ-105 mg/kg i.p.) at the CD97 dosage was administered to rats to cause seizures. ETOR (10 mg/kg p.o.) was adminis...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Atatürk University
2024-07-01
|
| Series: | Pharmata |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/en/download/article-file/4043270 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849325335184670720 |
|---|---|
| author | S. Aparna Chakali Ayyanna Dharani Prasad P Navaneetha Krishnan Subramanam R. Prakash Narahari N Palei Jayaraman Rajangam |
| author_facet | S. Aparna Chakali Ayyanna Dharani Prasad P Navaneetha Krishnan Subramanam R. Prakash Narahari N Palei Jayaraman Rajangam |
| author_sort | S. Aparna |
| collection | DOAJ |
| description | Objective: The effect of Etoricoxib (ETOR) on the link between blood glucose and seizure prevention in chemo-convulsive rats was investigated in this study. Methods: Pentylenetetrazol (PTZ-105 mg/kg i.p.) at the CD97 dosage was administered to rats to cause seizures. ETOR (10 mg/kg p.o.) was administered for two weeks prior to seizure induction. On the 14th day, the animals were exposed to chemo convulsions, and the efficiency of ETOR in lowering clonus-type chemo convulsions (CC) as well as blood glucose levels were assessed. Morphometric analysis and chimney tests were performed to evaluate ETOR's neurotoxic profile. Actophotometer, rotarod, and hole board tests were employed for behavioral analysis. Results: When compared to control mice, pretreatment with ETOR (10 mg/kg p.o) resulted in a substantial delay in the onset of CC (p<0.05) and duration of CC (p<0.01). Acute ETOR treatment also considerably lowered blood glucose levels. The chimney test findings show that it has no effect on motor control and is not neurotoxic to the animals.Conclusion: Behavioral tests also demonstrated that, except for the diazepam-treated groups, no significant changes in muscle coordination, locomotion, or apprehensive behavior were detected in all experimental animals. Finally, the primary findings of this study showed that the PTZ group had considerably greater levels of hyperglycemia, which is reflected in the rat's early onset and longer duration of chemo-convulsions. However, ETOR medication reduced high blood glucose levels as well as the onset and duration of seizures, indicating ETOR's impact on blood glucose reduction and the relationship between blood glucose and seizure responses. |
| format | Article |
| id | doaj-art-364dc0e7e5ec439c8721138b3df3ffd3 |
| institution | Kabale University |
| issn | 2980-1966 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Atatürk University |
| record_format | Article |
| series | Pharmata |
| spelling | doaj-art-364dc0e7e5ec439c8721138b3df3ffd32025-08-20T03:48:27ZengAtatürk UniversityPharmata2980-19662024-07-0143647010.5281/zenodo.1262582555Ameliorative Protective Influence of Etoricoxib Against Chemo Convulsions Correlates with Blood Glucose Levels in RatsS. Aparna0https://orcid.org/0009-0005-0339-1646Chakali Ayyanna1https://orcid.org/0009-0004-0873-8672Dharani Prasad P2https://orcid.org/0009-0008-8608-8790Navaneetha Krishnan Subramanam3R. Prakash4https://orcid.org/0000-0002-0369-8219Narahari N Palei5https://orcid.org/0000-0002-2041-1849Jayaraman Rajangam6https://orcid.org/0000-0002-6367-0365Shri Venkateshwara College of Pharmacy, Ariyur, Puducherry-605102, IndiaCES College of Pharmacy, Kurnool-518218, Andhra Pradesh, IndiaMB School of Pharmaceutical Sciences, Mohan Babu University, Tirupati, 517 501. Andhra Pradesh, IndiaDr.Kalam College of Pharmacy, Avanam, Tanjore-614623,Tamil Nadu IndiaCrescent School of Pharmacy, BSACIST University, Chennai-600048, Tamil Nadu, IndiaAMITY Institute of Pharmacy, AMITY University, Lucknow, Uttar Pradesh- 226028, IndiaShri Venkateshwara College of PharmacyObjective: The effect of Etoricoxib (ETOR) on the link between blood glucose and seizure prevention in chemo-convulsive rats was investigated in this study. Methods: Pentylenetetrazol (PTZ-105 mg/kg i.p.) at the CD97 dosage was administered to rats to cause seizures. ETOR (10 mg/kg p.o.) was administered for two weeks prior to seizure induction. On the 14th day, the animals were exposed to chemo convulsions, and the efficiency of ETOR in lowering clonus-type chemo convulsions (CC) as well as blood glucose levels were assessed. Morphometric analysis and chimney tests were performed to evaluate ETOR's neurotoxic profile. Actophotometer, rotarod, and hole board tests were employed for behavioral analysis. Results: When compared to control mice, pretreatment with ETOR (10 mg/kg p.o) resulted in a substantial delay in the onset of CC (p<0.05) and duration of CC (p<0.01). Acute ETOR treatment also considerably lowered blood glucose levels. The chimney test findings show that it has no effect on motor control and is not neurotoxic to the animals.Conclusion: Behavioral tests also demonstrated that, except for the diazepam-treated groups, no significant changes in muscle coordination, locomotion, or apprehensive behavior were detected in all experimental animals. Finally, the primary findings of this study showed that the PTZ group had considerably greater levels of hyperglycemia, which is reflected in the rat's early onset and longer duration of chemo-convulsions. However, ETOR medication reduced high blood glucose levels as well as the onset and duration of seizures, indicating ETOR's impact on blood glucose reduction and the relationship between blood glucose and seizure responses.https://dergipark.org.tr/en/download/article-file/4043270blood glucosechemo convulsionsetoricoxibpentylenetetrazolseizure protection |
| spellingShingle | S. Aparna Chakali Ayyanna Dharani Prasad P Navaneetha Krishnan Subramanam R. Prakash Narahari N Palei Jayaraman Rajangam Ameliorative Protective Influence of Etoricoxib Against Chemo Convulsions Correlates with Blood Glucose Levels in Rats Pharmata blood glucose chemo convulsions etoricoxib pentylenetetrazol seizure protection |
| title | Ameliorative Protective Influence of Etoricoxib Against Chemo Convulsions Correlates with Blood Glucose Levels in Rats |
| title_full | Ameliorative Protective Influence of Etoricoxib Against Chemo Convulsions Correlates with Blood Glucose Levels in Rats |
| title_fullStr | Ameliorative Protective Influence of Etoricoxib Against Chemo Convulsions Correlates with Blood Glucose Levels in Rats |
| title_full_unstemmed | Ameliorative Protective Influence of Etoricoxib Against Chemo Convulsions Correlates with Blood Glucose Levels in Rats |
| title_short | Ameliorative Protective Influence of Etoricoxib Against Chemo Convulsions Correlates with Blood Glucose Levels in Rats |
| title_sort | ameliorative protective influence of etoricoxib against chemo convulsions correlates with blood glucose levels in rats |
| topic | blood glucose chemo convulsions etoricoxib pentylenetetrazol seizure protection |
| url | https://dergipark.org.tr/en/download/article-file/4043270 |
| work_keys_str_mv | AT saparna ameliorativeprotectiveinfluenceofetoricoxibagainstchemoconvulsionscorrelateswithbloodglucoselevelsinrats AT chakaliayyanna ameliorativeprotectiveinfluenceofetoricoxibagainstchemoconvulsionscorrelateswithbloodglucoselevelsinrats AT dharaniprasadp ameliorativeprotectiveinfluenceofetoricoxibagainstchemoconvulsionscorrelateswithbloodglucoselevelsinrats AT navaneethakrishnansubramanam ameliorativeprotectiveinfluenceofetoricoxibagainstchemoconvulsionscorrelateswithbloodglucoselevelsinrats AT rprakash ameliorativeprotectiveinfluenceofetoricoxibagainstchemoconvulsionscorrelateswithbloodglucoselevelsinrats AT naraharinpalei ameliorativeprotectiveinfluenceofetoricoxibagainstchemoconvulsionscorrelateswithbloodglucoselevelsinrats AT jayaramanrajangam ameliorativeprotectiveinfluenceofetoricoxibagainstchemoconvulsionscorrelateswithbloodglucoselevelsinrats |