Competing G protein‐coupled receptor kinases balance G protein and β‐arrestin signaling

Competing G protein‐coupled receptor kinases balance G protein and β‐arrestin signaling

Abstract Seven‐transmembrane receptors (7TMRs) are involved in nearly all aspects of chemical communications and represent major drug targets. 7TMRs transmit their signals not only via heterotrimeric G proteins but also through β‐arrestins, whose recruitment to the activated receptor is regulated by...

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Bibliographic Details
Main Authors: Domitille Heitzler, Guillaume Durand, Nathalie Gallay, Aurélien Rizk, Seungkirl Ahn, Jihee Kim, Jonathan D Violin, Laurence Dupuy, Christophe Gauthier, Vincent Piketty, Pascale Crépieux, Anne Poupon, Frédérique Clément, François Fages, Robert J Lefkowitz, Eric Reiter
Format: Article
Language:English
Published: Springer Nature 2012-06-01
Series:Molecular Systems Biology
Subjects:
β‐arrestin
7 transmembrane receptors
dynamical modeling
G protein
signal transduction
Online Access:https://doi.org/10.1038/msb.2012.22
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