The Role of Gut Microbiota Modification in Nonalcoholic Fatty Liver Disease Treatment Strategies
One of the most common chronic liver diseases is nonalcoholic fatty liver disease (NAFLD), which affects many people around the world. Gut microbiota (GM) dysbiosis seems to be an influential factor in the pathophysiology of NAFLD because changes in GM lead to fundamental changes in host metabolism....
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2024/4183880 |
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| author | Hessam Yaghmaei Amirhossein Bahanesteh Masood Soltanipur Sobhan Takaloo Mahdi Rezaei Seyed Davar Siadat |
| author_facet | Hessam Yaghmaei Amirhossein Bahanesteh Masood Soltanipur Sobhan Takaloo Mahdi Rezaei Seyed Davar Siadat |
| author_sort | Hessam Yaghmaei |
| collection | DOAJ |
| description | One of the most common chronic liver diseases is nonalcoholic fatty liver disease (NAFLD), which affects many people around the world. Gut microbiota (GM) dysbiosis seems to be an influential factor in the pathophysiology of NAFLD because changes in GM lead to fundamental changes in host metabolism. Therefore, the study of the effect of dysbiosis on the pathogenicity of NAFLD is important. European clinical guidelines state that the best advice for people with NAFLD is to lose weight and improve their lifestyle, but only 40% of people can achieve this goal. Accordingly, it is necessary to provide new treatment approaches for prevention and treatment. In addition to dietary interventions and lifestyle modifications, GM modification-based therapies are of interest. These therapies include probiotics, synbiotics, fecal microbiota transplantation (FMT), and next-generation probiotics. All of these treatments have had promising results in animal studies, and it can be imagined that acceptable results will be obtained in human studies as well. However, further investigations are required to generalize the outcomes of animal studies to humans. |
| format | Article |
| id | doaj-art-36322c6de4cc4ca9bcc61bd4c6ac7d43 |
| institution | Kabale University |
| issn | 2090-3456 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-36322c6de4cc4ca9bcc61bd4c6ac7d432025-02-03T05:29:35ZengWileyInternational Journal of Hepatology2090-34562024-01-01202410.1155/2024/4183880The Role of Gut Microbiota Modification in Nonalcoholic Fatty Liver Disease Treatment StrategiesHessam Yaghmaei0Amirhossein Bahanesteh1Masood Soltanipur2Sobhan Takaloo3Mahdi Rezaei4Seyed Davar Siadat5Department of BiologyStudent Research CommitteeDepartment of Mycobacteriology and Pulmonary ResearchBiomedical Engineering DepartmentDepartment of Mycobacteriology and Pulmonary ResearchDepartment of Mycobacteriology and Pulmonary ResearchOne of the most common chronic liver diseases is nonalcoholic fatty liver disease (NAFLD), which affects many people around the world. Gut microbiota (GM) dysbiosis seems to be an influential factor in the pathophysiology of NAFLD because changes in GM lead to fundamental changes in host metabolism. Therefore, the study of the effect of dysbiosis on the pathogenicity of NAFLD is important. European clinical guidelines state that the best advice for people with NAFLD is to lose weight and improve their lifestyle, but only 40% of people can achieve this goal. Accordingly, it is necessary to provide new treatment approaches for prevention and treatment. In addition to dietary interventions and lifestyle modifications, GM modification-based therapies are of interest. These therapies include probiotics, synbiotics, fecal microbiota transplantation (FMT), and next-generation probiotics. All of these treatments have had promising results in animal studies, and it can be imagined that acceptable results will be obtained in human studies as well. However, further investigations are required to generalize the outcomes of animal studies to humans.http://dx.doi.org/10.1155/2024/4183880 |
| spellingShingle | Hessam Yaghmaei Amirhossein Bahanesteh Masood Soltanipur Sobhan Takaloo Mahdi Rezaei Seyed Davar Siadat The Role of Gut Microbiota Modification in Nonalcoholic Fatty Liver Disease Treatment Strategies International Journal of Hepatology |
| title | The Role of Gut Microbiota Modification in Nonalcoholic Fatty Liver Disease Treatment Strategies |
| title_full | The Role of Gut Microbiota Modification in Nonalcoholic Fatty Liver Disease Treatment Strategies |
| title_fullStr | The Role of Gut Microbiota Modification in Nonalcoholic Fatty Liver Disease Treatment Strategies |
| title_full_unstemmed | The Role of Gut Microbiota Modification in Nonalcoholic Fatty Liver Disease Treatment Strategies |
| title_short | The Role of Gut Microbiota Modification in Nonalcoholic Fatty Liver Disease Treatment Strategies |
| title_sort | role of gut microbiota modification in nonalcoholic fatty liver disease treatment strategies |
| url | http://dx.doi.org/10.1155/2024/4183880 |
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