Synthesis and Investigation of Antimicrobial and Antioxidant Activity of 3-Nitro-N- (3-chloro-2-oxo-substituted-phenyl-azetidin-1-yl)naphtho [2,1-b]furan-2-carboxamides
Ethyl-3-nitronaphtho[2,1-b]furan-2-carboxylate (2) has been synthesized from ethyl naphtha [2,1-b]furan-2-carboxylate (1). This nitro product on reaction with hydrazine hydrate formed 3-nitronaphtho [2,1-b] furan-2-carbohydrazide (3). Various Schiff bases 3-nitro-N1(aryl-methylene)-substituted-napht...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/863547 |
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| author | K. Shashikala Devi M. Ramaiah D. L. Roopa V. P. Vaidya |
| author_facet | K. Shashikala Devi M. Ramaiah D. L. Roopa V. P. Vaidya |
| author_sort | K. Shashikala Devi |
| collection | DOAJ |
| description | Ethyl-3-nitronaphtho[2,1-b]furan-2-carboxylate (2) has been synthesized from ethyl naphtha [2,1-b]furan-2-carboxylate (1). This nitro product on reaction with hydrazine hydrate formed 3-nitronaphtho [2,1-b] furan-2-carbohydrazide (3). Various Schiff bases 3-nitro-N1(aryl-methylene)-substituted-naphtho [2,1-b]furan-2-carbohydrazides 4(a-g) were obtained by treating hydrazide (3) with different aldehydes. These Schiff bases on reaction with chloro acetyl chloride in presence of triethylamine in dioxane yielded 3-nitro-N-(3-chloro-2-oxo-substituted-phenyl-azetidine-1-yl) naphtha [2,1-b]furan-2-carboxamides 5(a-g). All the newly synthesized compounds have been characterized by spectral and analytical studies. The Schiff bases, 4a-g and azetidione derivatives, 5a-g have been studied for antioxidant and antimicrobial activities. |
| format | Article |
| id | doaj-art-362ee8653f57423ea48bad114ffe8beb |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-362ee8653f57423ea48bad114ffe8beb2025-08-20T03:55:07ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-017S1S358S36210.1155/2010/863547Synthesis and Investigation of Antimicrobial and Antioxidant Activity of 3-Nitro-N- (3-chloro-2-oxo-substituted-phenyl-azetidin-1-yl)naphtho [2,1-b]furan-2-carboxamidesK. Shashikala Devi0M. Ramaiah1D. L. Roopa2V. P. Vaidya3Department of Chemistry, Maharani’s Science College for Women, Bangalore, Karnataka, IndiaDepartment of Chemistry, NMKRV College for Women, Bangalore, Karnataka, IndiaDepartment of Chemistry, NMKRV College for Women, Bangalore, Karnataka, IndiaDepartment of Chemistry, Kuvempu University, Jnana Sahyadri Shankaraghatta-577451, Dist: Shimoga, Karnataka, IndiaEthyl-3-nitronaphtho[2,1-b]furan-2-carboxylate (2) has been synthesized from ethyl naphtha [2,1-b]furan-2-carboxylate (1). This nitro product on reaction with hydrazine hydrate formed 3-nitronaphtho [2,1-b] furan-2-carbohydrazide (3). Various Schiff bases 3-nitro-N1(aryl-methylene)-substituted-naphtho [2,1-b]furan-2-carbohydrazides 4(a-g) were obtained by treating hydrazide (3) with different aldehydes. These Schiff bases on reaction with chloro acetyl chloride in presence of triethylamine in dioxane yielded 3-nitro-N-(3-chloro-2-oxo-substituted-phenyl-azetidine-1-yl) naphtha [2,1-b]furan-2-carboxamides 5(a-g). All the newly synthesized compounds have been characterized by spectral and analytical studies. The Schiff bases, 4a-g and azetidione derivatives, 5a-g have been studied for antioxidant and antimicrobial activities.http://dx.doi.org/10.1155/2010/863547 |
| spellingShingle | K. Shashikala Devi M. Ramaiah D. L. Roopa V. P. Vaidya Synthesis and Investigation of Antimicrobial and Antioxidant Activity of 3-Nitro-N- (3-chloro-2-oxo-substituted-phenyl-azetidin-1-yl)naphtho [2,1-b]furan-2-carboxamides E-Journal of Chemistry |
| title | Synthesis and Investigation of Antimicrobial and Antioxidant Activity of 3-Nitro-N- (3-chloro-2-oxo-substituted-phenyl-azetidin-1-yl)naphtho [2,1-b]furan-2-carboxamides |
| title_full | Synthesis and Investigation of Antimicrobial and Antioxidant Activity of 3-Nitro-N- (3-chloro-2-oxo-substituted-phenyl-azetidin-1-yl)naphtho [2,1-b]furan-2-carboxamides |
| title_fullStr | Synthesis and Investigation of Antimicrobial and Antioxidant Activity of 3-Nitro-N- (3-chloro-2-oxo-substituted-phenyl-azetidin-1-yl)naphtho [2,1-b]furan-2-carboxamides |
| title_full_unstemmed | Synthesis and Investigation of Antimicrobial and Antioxidant Activity of 3-Nitro-N- (3-chloro-2-oxo-substituted-phenyl-azetidin-1-yl)naphtho [2,1-b]furan-2-carboxamides |
| title_short | Synthesis and Investigation of Antimicrobial and Antioxidant Activity of 3-Nitro-N- (3-chloro-2-oxo-substituted-phenyl-azetidin-1-yl)naphtho [2,1-b]furan-2-carboxamides |
| title_sort | synthesis and investigation of antimicrobial and antioxidant activity of 3 nitro n 3 chloro 2 oxo substituted phenyl azetidin 1 yl naphtho 2 1 b furan 2 carboxamides |
| url | http://dx.doi.org/10.1155/2010/863547 |
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