Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential

Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential

Gastrointestinal (GI) cancers, including esophageal, gastric, pancreatic, liver, and colorectal malignancies, represent a major global health burden due to their high incidence, aggressive nature, and limited treatment outcomes. This review explores the therapeutic potential of carvacrol, a naturall...

Full description

Saved in:

Bibliographic Details
Main Authors:	Nitika Patwa, Gagandeep Singh, Vikas Sharma, Priyanka Chaudhary, Bunty Sharma, Shafiul Haque, Vikas Yadav, Shakti Ranjan Satapathy, Hardeep Singh Tuli
Format:	Article
Language:	English
Published:	MDPI AG 2025-05-01
Series:	Biomolecules
Subjects:	carvacrol gastrointestinal cancers anticancer mechanisms nanotechnology synergistic therapy
Online Access:	https://www.mdpi.com/2218-273X/15/6/777
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Thymol and carvacrol against Klebsiella: anti-bacterial, anti-biofilm, and synergistic activities—a systematic review
by: Kousha Farhadi, et al.
Published: (2024-10-01)

Role of emodin to prevent gastrointestinal cancers: recent trends and future prospective
by: Falak Thakral, et al.
Published: (2025-04-01)

Optimisation of the carvacrol encapsulation method into PHBV nanoparticles
by: Aynura Rzayeva, et al.
Published: (2024-12-01)

Mechanistic Study on the Alleviation of Endometritis in Mice Through Inhibition of NF-κB and MAPK Signaling Pathways by Berberine and Carvacrol
by: Xiaoshan Liang, et al.
Published: (2025-04-01)

Early-life immunomodulation by carvacrol delivered in ovo in broiler chickens
by: Mila M.Y. Meijer, et al.
Published: (2024-12-01)

The effect of carvacrol on oxido-inflammatory ovarian injury and infertility induced by ischemia-reperfusion in rats
by: Nurullah Sahin, et al.
Published: (2022-03-01)

Suppression of Epidermal Growth Factor Receptor by Erlotinib Attenuates Carvacrol-induced Skin Inflammation
by: Yujing Wang, et al.
Published: (2024-12-01)

Silymarin: a promising modulator of apoptosis and survival signaling in cancer
by: Ujjawal Sharma, et al.
Published: (2025-01-01)

The effect of carvacrol on kidney injury caused by isopreterenol-induced myocardial infarction
by: Gülhan Ünlü, et al.
Published: (2025-07-01)

The Effect of “Carvacrol” on Ischemia-Reperfusion Injury in the Skeletal Muscles of Rats
by: Barış Mardin, et al.
Published: (2024-07-01)

Antibacterial effect of free, nanoemulsified and protein-complexed carvacrol
by: Ralph Nehme, et al.
Published: (2025-03-01)

Determination of Structural, Conformational and Antiradical Properties of Carvacrol Encapsulated with Yeast Cells (Saccharomyces cerevisiae)
by: Kevser KARAMAN
Published: (2022-03-01)

MicroRNAs at the crossroad of cancer therapeutics: insights from WNT signaling & flavonoids
by: Akanksha Gupta, et al.
Published: (2025-08-01)

Carvacrol attenuates mucosal barrier impairment and tumorigenesis by regulating gut microbiome
by: Yating Fan, et al.
Published: (2025-08-01)

Cardioprotective effects of carvacrol in the isoproterenol-induced myocardial infarction model
by: Seda Koçak, et al.
Published: (2025-07-01)

In vitro antitrichomonal activity of Satureja khuzestanica and main essential oil components carvacrol, thymol, and eugenol
by: Faezeh Karami, et al.
Published: (2023-01-01)

Carvacrol and caprylic acid nanoemulsions as natural sanitizers for controlling Salmonella Enteritidis biofilms on stainless steel surfaces
by: Trushenkumar Shah, et al.
Published: (2025-06-01)

The inflammatory response to Escherichia coli lipopolysaccharide is mitigated by in ovo delivery of carvacrol in broiler chicks
by: Mila M.Y. Meijer, et al.
Published: (2025-03-01)

Effect of Corona Treatment Method to Carvacrol Nanocoating Process for Carvacrol/Halloysite-Nanotube/Low-Density-Polyethylene Active Packaging Films Development
by: Aris E. Giannakas, et al.
Published: (2024-07-01)

Carvacrol attenuated haloperidol-induced Parkinson’s disease via TNF/NFκβ-NLRP3-mediated pyroptosis
by: Faisal Albaqami, et al.
Published: (2025-02-01)

A Straightforward Electrochemical Approach for the Simultaneous Determination of Thymol and Carvacrol in Essential Oils
by: Sabrina Antonella Maccio, et al.
Published: (2024-09-01)

Anthelmintic activity on Haemonchus contortus and toxicity of benzoyl-carvacrol: a study in vitro, in silico and in vivo
by: Andreza Pereira Braga, et al.
Published: (2025-03-01)

Preparation and Efficacy of Microemulsion Carvacrol-Based Fruit and Vegetable Cleaner and Its Application on Cherry Tomatoes
by: Yanshuo Wang, et al.
Published: (2025-01-01)

Impact of a Carvacrol Treatment on Post-Harvest Ripening Quality and Cell Wall Metabolism in the Kiwifruit
by: Donglan Luo, et al.
Published: (2024-12-01)

Antibacterial activities of oregano essential oils and their active components
by: Lei Tao, et al.
Published: (2025-04-01)

Mechanisms of action and resistance prevention of synergistic thymol and carvacrol combinations with antibiotics in Staphylococcus aureus and Acinetobacter baumannii
by: Cristina Gan, et al.
Published: (2025-06-01)

Carvacrol acetate activated Nrf2 modulates mitophagy for the treatment of neurocyte oxidative stress induced by chlorpyrifos
by: Hong-Ling Zhou, et al.
Published: (2025-01-01)

Synergistic Effects of Carvacrol and Thymol on Docetaxel-Induced Cytotoxicity in the A549 Cell Line by Evaluating Cell Viability and Oxidative Stress
by: Mohammad Shokrzadeh, et al.
Published: (2025-07-01)

Antifungal mechanism of carvacrol and osthole can disrupt cell structure integrity and interfere with energy metabolism in Neopestalotiopsis ellipsospora
by: Huifang Liu, et al.
Published: (2025-07-01)

Efficacy of a feed additive consisting of carvacrol (Nimicoat®) for weaned piglets (Techna France Nutrition)
by: EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), et al.
Published: (2024-03-01)

The Effect of Carvacrol as the Main Polyphenolic Compound of Thymus eriocalyx Ronniger Jalas on the Inhibition of Bacteria growth
by: Somayeh Farahmand, et al.
Published: (2025-03-01)

Carvacrol Essential Oil as a Neuroprotective Agent: A Review of the Study Designs and Recent Advances
by: Fahad Khan Tareen, et al.
Published: (2024-12-01)

Effects of carvacrol on growth performance, carcass traits, serum biochemistry, and intestinal gut microflora of broiler chickens
by: Imen Belhadj Slimen, et al.
Published: (2025-05-01)

The effects of carvacrol on the cardiac apoptosis gene expression levels in heart tissue of obese male rats induced by high-fat diet
by: Mahdi Ahmadi, et al.
Published: (2025-03-01)

Investigation of The Effect of Carvacrol Addition on The Change of Some Physicochemical and Bioactive Properties of Apple Juice Contaminated with Zygosaccharomyces bailii
by: Kevser Karaman, et al.
Published: (2019-11-01)

Novel Photodynamic Inactivation Strategy for Salmonella Enteritidis PT4 on Eggshells: Exploiting the Antimicrobial Potential of Curcumin and Carvacrol
by: Erhan Keyvan, et al.
Published: (2025-01-01)

Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease
by: Hossein Haddadi, et al.

Effects of carvacrol, alfa pinene and cineole-rich essential oil mixed on performance, egg production and quality and egg lipid peroxidation in laying quails
by: Aziz Bulbul, et al.

Blocking the shikimate pathway amplifies the impact of carvacrol on biofilm formation in Candida albicans
by: Ali Molaeitabari, et al.
Published: (2025-03-01)

The Antimicrobial Effect of Thymol and Carvacrol in Combination with Organic Acids Against Foodborne Pathogens in Chicken and Beef Meat Fillets
by: Ioanna Mantzourani, et al.
Published: (2025-01-01)